Effects of non-linear resistance training and curcumin supplementation on the liver biochemical markers levels and structure in older women with non-alcoholic fatty liver disease

Curcumin and Biochemical Parameters in Metabolic-Associated Fatty Liver Disease (MAFLD)—A Review

“…Chashmniam et al [ 31 ] did not report statistical significance for any of the parameters examined, but also noted a decrease in ALT levels (50.08 ± 7.27 U/L vs. 43.28 ± 4.91 U/L) and AST (35.16 ± 3.9 U/L vs. 31.85 ± 3.41 U/L). All six of the other studies observed decreases in ALT levels after supplementation, but these were not statistically significant [ 29 , 30 , 32 , 34 , 35 , 36 ]. For AST, Ghaffari et al [ 30 ] observed an increase in levels from 24 ± 11.5 U/L to 24.1 ± 8.90 U/L ( p = 0.92); decreases were observed in the remaining studies, but only Panahi et al [ 33 ] and Rahmani et al [ 28 ] obtained statistically significant results (35.4 ± 11.9 U/L vs. 22.6 ± 7.2 U/L, p < 0.001 and 28.88 ± 10.60 U/L vs. 23.84 ± 7.83 U/L, p < 0.001, respectively).…”

“…In most of the trials, the mean age of the patients was in the range of 37.41–49.4 years ( Table 2 ) [ 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. In one study, the average age of the respondents was 66.72 years [ 35 ], in another, the mean age of the study group was not given, but ranged between 18–70 years [ 36 ]. The average BMI values were in the 27.6–31.81 kg/m 2 range.…”

“…Differences in duration and doses of the supplement were observed between the interventions ( Table 3 ). In three studies, the supplementation period lasted 12 weeks [ 29 , 30 , 35 ]; in the other studies, it was 8 weeks [ 28 , 31 , 32 , 33 , 34 , 36 ]. The daily supplement doses taken by patients in each trial were varied.…”

“…The daily supplement doses taken by patients in each trial were varied. Kelardah et al [ 29 , 35 ] used 80 mg/day curcumin as nanomicelle in two interventions. Chashmniam et al [ 31 ], Mirhafez et al [ 32 ], and Hariri et al [ 34 ] used phospholipid curcumin at 250 mg/day (equivalent to 50 mg pure curcumin).…”

“…All nine studies monitored ALT and AST levels before and after supplementation [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. Only Panahi et al [ 33 ] (ALT: 40.7 ± 15.0 U/L vs. 22.0 ± 7.2 U/L, p < 0.001; AST: 35.4 ± 11.9 U/L vs. 22.6 ± 7.2 U/L, p < 0.001) and Rahmani et al [ 28 ] (ALT: 39.07 ± 19.79 U/L vs. 36.08 ± 46.58 U/L, p < 0.001; AST: 28.88 ± 10.60 U/L vs. 23.84 ± 7.83 U/L, p < 0.001) observed a statistically significant improvement in these parameters…”