Effects of Non-directional Mechanical Trauma on Gastrointestinal Tract Injury in Rats

Wen, Lianpu; Gao, Chuanzhou; Piao, Hong‐Guang; Zhao, Hui; Yu, Dao‐Yi; Zhu, Liang; Li, Shuzhuang

doi:10.3389/fphys.2021.649554

Cited by 2 publications

(2 citation statements)

References 36 publications

(41 reference statements)

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“…but not in Ebo.PHLF vs. Enbo.PHLF. Previous study has shown that the intestinal microbiome causes health disorders under various conditions, such as abdominal surgery and antibacterial therapy (40). Consistent with these reports, our results showed that extended hepatectomy causes dysbiosis of the intestinal microbiome.…”

Section: Discussionsupporting

confidence: 92%

Gut microbiome dysbiosis in patients with hepatitis B virus-related hepatocellular carcinoma after extended hepatectomy liver failure

Peng¹,

Xu²,

Zeng³

et al. 2022

Ann Transl Med

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Background: Hepatitis B virus-related hepatocellular carcinoma (B-HCC) negatively affects the gut microbiome. This study aimed to investigate the gut microbiome profiles and functions post-hepatectomy liver failure (PHLF) after extended hepatectomy (e-PHLF) to obtain valuable insights, identify potential diagnostic biomarkers, and assist in the treatment of this disease.Methods: B-HCC patients who underwent extended hepatectomy were consecutively recruited and divided into Group A (n=15) and Group B (n=15) based on the presence and absence of e-PHLF, respectively.The relationships between gut microbiota and extended hepatectomy liver failure were explored using 16S ribosomal RNA (16S rRNA) gene sequencing data.Results: Following extended hepatectomy, the α-diversity of Group A was significantly higher than that of Group B (Shannon P=0.034 or Simpson P=0.031), and the β-diversity differed significantly between Groups A and B (P=0.004, R=0.100). At the genus level, 10 bacterial genera (Bacteroides, Pantoea, Methylobacterium-Methylorubrum, Inquilinus, Mycobacterium, Allisonella, Helicobacter, GCA-900066575, IS-44, and Faecalibacterium) were significantly enriched in Group A, whereas five genera (Papillibacter, Scardovia, Turicibacter, Catabacter, and Senegalimassilia) were significantly enriched in Group B. The highly abundant genera Bacteroides, Pantoea, Faecalibacterium, and Turicibacter participated in multiple amino acid metabolism pathways, organic acid metabolism pathways, pyrimidine metabolism pathways, palmitate biosynthesis, and stearate biosynthesis. Redundancy analysis showed that four environmental factors (total bilirubin, international normalized ratio, prealbumin, and albumin) were significantly correlated with intestinal microorganisms. The formation of interaction networks between different gut microbiomes revealed important correlations between the gut microbiome, and there was a significant correlation between the highly abundant gut microbiome and main functions. Conclusions:The gut microbiota characteristics in B-HCC patients after extended hepatectomy liver failure might allow for the use of non-invasive biomarkers for disease diagnosis and treatment.

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Section: Discussionsupporting

confidence: 92%

Gut microbiome dysbiosis in patients with hepatitis B virus-related hepatocellular carcinoma after extended hepatectomy liver failure

Peng¹,

Xu²,

Zeng³

et al. 2022

Ann Transl Med

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“…11 Furthermore, sports like rugby, American football, and hockey involve frequent physical contact between the players, which, in theory, could contribute to GI disturbances through mechanical trauma. 12 To the authors' knowledge, there are no published survey studies that have examined the prevalence of GI issues among team-sport athletes exclusively.…”

Section: Introductionmentioning

confidence: 99%

Occurrence and Impacts of Gastrointestinal Symptoms in Team-Sport Athletes: A Preliminary Survey

Wilson

Fearn

Pugh³

2022

Clinical Journal of Sport Medicine

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Objectives:Although gastrointestinal (GI) symptoms are prevalent in endurance athletes, scant research has examined GI symptoms in team-sport athletes, their impacts, and explanatory factors. This study aimed to assess the prevalence and severity of GI symptoms in team-sport athletes and identify potential risk factors.Design:An observational anonymous survey.Setting:Online.Participants:Hundred forty-three athletes (79 men and 64 women) from team-based sports, with soccer, rugby, and American football athletes comprising approximately 75% of the sample.Assessments of Risk Factors:Age, gender, body mass index, competition experience, trait anxiety, and resting GI symptoms.Main Outcomes:Gastrointestinal symptoms during training and competition.Results:Overall, past-month GI symptoms during training and competition were mild and relatively infrequent. However, 13.9% and 37.5% of men and women, respectively, reported that GI symptoms had ever impacted their performance. In comparison to men, women reported that nausea, bloating, and abdominal cramping were more likely to have affected performance (P < 0.05). Women also had higher trait anxiety and higher scores for resting GI symptoms, during-training GI symptoms, and during-competition GI symptoms (P < 0.001). Resting GI symptoms were the strongest predictor of training and competition GI symptoms (ρ = 0.46-0.67), although trait anxiety was also consistently correlated with competition GI symptoms (ρ = 0.29-0.38).Conclusions:This study suggests that female team-sport athletes experience a higher burden of GI symptoms than males, and that resting symptoms and anxiety predict competition symptoms. Interventions targeting anxiety could theoretically reduce GI symptoms in some team-sport athletes, but this should be confirmed through experimental designs.

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Effects of Non-directional Mechanical Trauma on Gastrointestinal Tract Injury in Rats

Cited by 2 publications

References 36 publications

Gut microbiome dysbiosis in patients with hepatitis B virus-related hepatocellular carcinoma after extended hepatectomy liver failure

Gut microbiome dysbiosis in patients with hepatitis B virus-related hepatocellular carcinoma after extended hepatectomy liver failure

Occurrence and Impacts of Gastrointestinal Symptoms in Team-Sport Athletes: A Preliminary Survey

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