Effects of Nitrous Oxide on Human Regional Cerebral Blood Flow and Isolated Pial Arteries

Reinstrup, Peter; Ryding, Erik; Algotsson, Lars; Berntman, Leif; Uski, Tore

doi:10.1097/00000542-199408000-00018

Cited by 73 publications

(41 citation statements)

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“…A mean EtCO 2 reduction of 15 mm Hg led to a mean flow decrease of 107 mL/min (2%/mm Hg). Similar ranges of 1.9%/mm Hg to 3.5%/mm Hg were shown by dynamic CT and PET studies (Bednarczyk et al, 1990;Ito et al, 2002;Reinstrup et al, 1994) while our study found a CO 2 reactivity of 3.2%/mm Hg. CBV in our study did not change significantly during hypocapnia.…”

Section: Figsupporting

confidence: 90%

Ultrasonographic Assessment of Global Cerebral Blood Volume in Healthy Adults

Doepp

Schreiber

Brunecker

et al. 2003

J Cereb Blood Flow Metab

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Summary:The authors describe a new ultrasonographic method for analysis of global cerebral blood volume (CBV) and its application under controlled hyperventilation. CBV was determined as the product of global cerebral blood flow volume (CBF) and global cerebral circulation time. CBF was measured by duplex sonography and calculated as the sum of flow volumes in both internal carotid arteries and vertebral arteries. Extracranial Doppler assessed cerebral circulation time by determining the time interval of echo-contrast bolus arrival between internal carotid artery and contralateral internal jugular vein. Forty-four healthy volunteers (mean age 45 ± 19 years, range 20-79 years) were studied. Mean CBV was 77 ± 13 mL.

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Section: Figsupporting

confidence: 90%

Ultrasonographic Assessment of Global Cerebral Blood Volume in Healthy Adults

Doepp

Schreiber

Brunecker

et al. 2003

J Cereb Blood Flow Metab

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“…Nitrous oxide promotes weak sympathometic effects and is known to increase cerebral blood flow, possibly due to increased regional metabolism [8,9]. It is also known to have an EEG activating effect, it inhibits isoflurane's suppression of the EEG, and it reduces the proportion of burst suppression [10,11].…”

Section: Discussionmentioning

confidence: 99%

The effects of nitrous oxide on the auditory evoked potential index during sevoflurane anaesthesia

2002

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SummaryWe have studied the effects of nitrous oxide on the auditory evoked response index (AAI TM -index) derived from the A-line monitoring device during sevoflurane anaesthesia in 21 patients undergoing minor ambulatory surgery. During sevoflurane anaesthesia with an AAI TM -index < 30, the addition or withdrawal of nitrous oxide in a concentration of 66% end tidal did not show any linear dose dependent change in AAI TM -index. However, comparing nitrous oxide > 40% to nitrous oxide < 10% end tidal concentration the AAI TM -index did decrease, p < 0.05. The AAI TM -index is either non-linear at deeper anaesthetic levels or is insensitive to the anaesthetic effects of nitrous oxide in terms of MAC-multiples.

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“…The lack of pharmacokinetic information for the rhesus monkey precluded the use of intravenous analgesics, including opiates, as it would have been impossible to maintain stable effect site concentrations throughout the study. It has been shown that N 2 O increases CBF [25][26][27][28], and its effect plateaus at an inhalation concentration of approximately 30% [28]. But it has also been reported that the inhalation of 20% N 2 O does not affect the coupling of cerebral metabolism and blood flow [27].…”

Section: Discussionmentioning

confidence: 99%