Effects of nitric oxide-modulating amino acids on coronary vessels: relevance to sepsis

Mitchell, Jane A.; Gray, P A; Anning, Peter D; Woods, Mandy; Warner, Timothy D.; Evans, Timothy W.

doi:10.1016/s0014-2999(99)00837-7

Cited by 17 publications

(5 citation statements)

References 26 publications

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“…Glucosamine, the main bioproduct of the hexosamine biosynthetic pathway, inhibits nitric oxide synthesis in endothelial cells. Moreover, increasing extracellular concentrations of both glutamine and glucose resulted in decreased nitric oxide production by endothelial cells (Giugliano et al, 1997;Okuda et al, 1997;Cosentino and Luscher, 1998;Mitchell et al, 2000), suggesting that the glucosamine biosynthetic pathway mediates the inhibition of endothelial nitric oxide synthesis induced by hyperglycemia and high plasma glutamine levels (Wu et al, 2001).…”

Section: Insulin Secretion and Actionmentioning

confidence: 99%

Molecular mechanisms of glutamine action

Curi

Lagranha

Doi

et al. 2005

Journal Cellular Physiology

412

300

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Glutamine is the most abundant free amino acid in the body and is known to play a regulatory role in several cell specific processes including metabolism (e.g., oxidative fuel, gluconeogenic precursor, and lipogenic precursor), cell integrity (apoptosis, cell proliferation), protein synthesis, and degradation, contractile protein mass, redox potential, respiratory burst, insulin resistance, insulin secretion, and extracellular matrix (ECM) synthesis. Glutamine has been shown to regulate the expression of many genes related to metabolism, signal transduction, cell defense and repair, and to activate intracellular signaling pathways. Thus, the function of glutamine goes beyond that of a simple metabolic fuel or protein precursor as previously assumed. In this review, we have attempted to identify some of the common mechanisms underlying the regulation of glutamine dependent cellular functions.

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Section: Insulin Secretion and Actionmentioning

confidence: 99%

Molecular mechanisms of glutamine action

Curi

Lagranha

Doi

et al. 2005

Journal Cellular Physiology

412

300

View full text Add to dashboard Cite

show abstract

“…The other AA that deserves special attention with respect to endothelial function is L-glutamine. Increased concentrations of glutamine and glucose inhibit nitric oxide synthesis in endothelial cells and impair endothelialdependent relaxation (201,202,203,204). Elevated levels of glucose activate the glucosamine synthetic pathway, as well as the production of superoxide and other ROS in endothelial cells (162,205).…”

Section: Amino Acids and Endothelial Cell Function In Diabetesmentioning

confidence: 99%

Amino acids and diabetes: implications for endocrine, metabolic and immune function

Newsholme

Abdulkader²,

Rebelato³

et al. 2011

Front Biosci

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Aberrant alterations in glucose and lipid concentrations and their pathways of metabolism are a hallmark of diabetes. However, much less is known about alterations in concentrations of amino acids and their pathways of metabolism in diabetes. In this review we have attempted to highlight, integrate and discuss common alterations in amino acid metabolism in a wide variety of cells and tissues and relate these changes to alterations in endocrine, physiologic and immune function in diabetes.

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“…Reduced arginine availability may limit NO synthesis because provision of the arginine pool for NO synthesis depends for Ͼ50% on extracellular sources of arginine (14, 66,67,[71][72][73]. Although NOS-2 activity increases during sepsis, activity of the other NOS isoforms seems down-regulated (69, 74 -77).…”

Section: Arginine Catabolism In Sepsismentioning

confidence: 99%