Effects of Nigella sativa Seeds on Intestinal Smooth Muscle

Aqel, M.

doi:10.3109/13880209309082918

Cited by 27 publications

(13 citation statements)

References 6 publications

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“…Linoleic acid may stimulate cholesterol excretion into the intestine (Tollba & Hassan, 2003). Nonetheless, the increase in total protein and albumin may be because of an immunostimulanting effect of nigella seed oil (Aqel, 1993). Nigella seed oil contains reasonable amounts of macroand micro-mineral elements that are involved in the growth process.…”

Section: Discussionmentioning

confidence: 99%

Nigella seed oil as alternative to avilamycin antibiotic in broiler chicken diets

Saleh¹

2014

SA J. An. Sci.

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This study was conducted to study the effect of nigella seed oil as an alternative to the antibiotic, avilamycin, on growth, digestibility, muscle fatty acid profile and some physiological parameters in broiler chickens. Fifty four chicks at 15 d of age (average weight, 320 ± 3 g) were divided into a control group and two treatment groups (n = 18). The control group was fed a basal diet and the experimental treatment groups were fed the basal diet supplemented with avilamycin at a level of 0.001% or nigella seed oil at 1 mL/kg. Growth performance and breast muscle fatty acid profile were measured. Although feed intake was not affected, bodyweight gain was increased, and thus feed conversion ratio was improved by feeding nigella seed oil compared with the control and avilamycin groups. Plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) concentrations were higher, while, plasma high-density lipoprotein cholesterol (HDL-C) acid level was lower and polyunsaturated fatty acid levels were higher in the muscle fat of birds receiving nigella seed oil than those receiving the other treatments. It is concluded that feeding nigella seed oil as alternative to avilamycin antibiotic improved growth performance, modified the fatty acids profile in muscles and enhances plasma total cholesterol, LDL and HDL concentrations, and glutathione peroxidase (GSH-Px) activity.

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Section: Discussionmentioning

confidence: 99%

Nigella seed oil as alternative to avilamycin antibiotic in broiler chicken diets

Saleh¹

2014

SA J. An. Sci.

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“…The volatile oil and ethanolic extract of N. sativa inhibited spontaneous movements of the rabbit jejunum as well as agonist-induced contractions and the spasmolytic effect involved calcium channel blockade. [24] The aqueus-methanolic extract of Nigella seeds also showed spasmolytic effect mediated through calcium antagonist effect thus providing scientific basis for its traditional use in diarrhoea. [22] Several mechanisms have been proposed to induce the diarrhoeal effect of castor oil.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-Diarrhoeal and Appetizer Effects of Nigella Sativa Seeds

Abed¹

2017

WJPR

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This study aims to investigate the anti-diarrheal and the appetizer activities of Nigella sativa seeds. To evaluate the anti-diarrheal effect using castor oil induced diarrhoea in albino wistar rats, crude extract of seeds was given to rats, at graded dose of 100, 250 & 500mg/kg by oral gavage, by using four experimentally induced diarrhoea treated groups each consist of five rats and one control group. Loperamide (3mg/kg p.o) were used as standard drugs. The crude extract at 500mg/kg showed a remarkable antidiarrhoeal activity manifested by significant decrease in number of wet stools and total number of stools, output in 4 hours. The results of this study indicate the presence of some active principles in the crude extract of Nigella sativa seeds possessing anti-diarrhoeal effect. To investigate appetizer effect of oral administration of Nigella sativa seeds, 36 adult healthy volunteers of either sex, of age 28, 44 ± 10, 53 years and mean BMI 24, 242 ± 3,107 kg/m2, were divided into four groups. The subjects were administered orally respectively at 1 tablet based on Fenugreek (600 mg), 1g, 2g and 3g of Nigella sativa seeds powder. After 20 min of treatments, we observed after 6 hour, the subjective appetite of study participants using a visual analog scale. The results show that oral administration of powder of Nigella sativa seeds significantly increased subjective appetite. These results may explain the rational uses of this seeds as antidiarrhoeal and appetizer agent in the traditional medicine.

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“…Nigella sativa, a plant native to South East Asia is known for its relaxant effect on smooth muscle tissue [37][38][39]. In addition, Boskabady and colleagues have demonstrated that extracts and oils from N. sativa have inhibitory effects on histamine (H1) receptors [40], stimulatory effects on β-adrenergic receptors [41] and anti-tussive effects [42].…”

Section: Plant-derived Therapies For Asthmamentioning

confidence: 99%

Herbal treatment in asthma and COPD – current evidence

2015

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Asthma and COPD are chronic inflammatory respiratory diseases affecting millions of people worldwide and increasing in prevalence. Current treatment options for both conditions aim to alleviate symptoms, improve patient quality of life and prevent disease progression rather than cure the underlying condition itself. Treatments available to patients include anti-inflammatory therapies, bronchodilators and inhaled corticosteroids. While these treatments have been deemed effective at alleviating disease symptoms and exacerbations they are not without their limitations. Overuse of some therapies can induce adverse effects in some patients such as increased risk of developing pneumonia and cardiac co-morbidities. Along with the risks of side effects not all patients will respond to the current treatment options and therefore there is an unmet need for additional or alternative treatments for asthma and COPD. One such area showing good promise in providing an alternative or add-on therapy is that of phytomedicine. Phytomedicine is defined as a plant-based traditional medical practice that uses various plant materials in modalities considered both preventive and therapeutic. This review focuses on recent human clinical trials using plant-based medicines for the treatment of asthma and COPD.

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Effects of Nigella sativa Seeds on Intestinal Smooth Muscle

Cited by 27 publications

References 6 publications

Nigella seed oil as alternative to avilamycin antibiotic in broiler chicken diets

Nigella seed oil as alternative to avilamycin antibiotic in broiler chicken diets

Evaluation of Anti-Diarrhoeal and Appetizer Effects of Nigella Sativa Seeds

Herbal treatment in asthma and COPD – current evidence

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