This study aims to investigate the anti-diarrheal and the appetizer activities of Nigella sativa seeds. To evaluate the anti-diarrheal effect using castor oil induced diarrhoea in albino wistar rats, crude extract of seeds was given to rats, at graded dose of 100, 250 & 500mg/kg by oral gavage, by using four experimentally induced diarrhoea treated groups each consist of five rats and one control group. Loperamide (3mg/kg p.o) were used as standard drugs. The crude extract at 500mg/kg showed a remarkable antidiarrhoeal activity manifested by significant decrease in number of wet stools and total number of stools, output in 4 hours. The results of this study indicate the presence of some active principles in the crude extract of Nigella sativa seeds possessing anti-diarrhoeal effect. To investigate appetizer effect of oral administration of Nigella sativa seeds, 36 adult healthy volunteers of either sex, of age 28, 44 ± 10, 53 years and mean BMI 24, 242 ± 3,107 kg/m2, were divided into four groups. The subjects were administered orally respectively at 1 tablet based on Fenugreek (600 mg), 1g, 2g and 3g of Nigella sativa seeds powder. After 20 min of treatments, we observed after 6 hour, the subjective appetite of study participants using a visual analog scale. The results show that oral administration of powder of Nigella sativa seeds significantly increased subjective appetite. These results may explain the rational uses of this seeds as antidiarrhoeal and appetizer agent in the traditional medicine.
The purpose of this study was to assess the effects of powder from Nigella sativa seeds on anthropometrical parameters and appetite in normal weight, overweight and obese subjects. This prospective study was conducted in 85 subjects. 34 adult healthy and normal weight subjects and 51 overweight or obese subjects. Each group was divided into four groups. The first always represented the control group. The subjects were administered at 1 g, 2g and 3 g of Nigella sativa seeds powder orally respectively. Anthropometric indices were evaluated at baseline and at the end of the trial. After 20 min of treatments, the subjective appetite of study participants using a visual analogue scale. The results show that oral administration of powder of Nigella sativa seeds significantly increased scores of appetite and mean BMI value in normal weight subjects and significantly decreased these parameters in overweight and obese subjects. These results may explain the rational uses of this seeds as an appetizer and as an anti-obesity agent in the traditional medicine.
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