Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: A randomized, double-blind, placebo-controlled clinical trial

Kolahdooz, Maryam; Nasri, Sima; Modarres, Shahrzad Zadeh; Kianbakht, S; Huseini, H Fallah

doi:10.1016/j.phymed.2014.02.006

Cited by 103 publications

(71 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Daily intake of N. sativa oil for 2-3 months improved abnormal semen quality in infertile men without any adverse effects (Kolahdooz et al 2014). …”

Section: Herbal Remedies With Female Antifertility and Abortificiant mentioning

confidence: 99%

“…It was also found to improve hyperlipidemic male rat fertility and spermatogenesis (Bashandy 2007;Al-Saaidi et al 2009;Mohammad et al 2009;Parandin et al 2012;Mansour et al 2013;Marbat et al 2013). Thus, daily intake of N. sativa oil for 2-3 months improved abnormal semen quality in infertile men without any adverse effects (Kolahdooz et al 2014). Cinnamum zeylanicum was found to enhance male fertility and alleviate impotency in diabetic rats via increasing testicular weight and ameliorating degenerative legions, increasing testosterone serum levels, improving semen quality and quantity (Hafez 2010;Shalaby & Mouneir 2010;Yuce et al 2013;Fathiazad et al 2013).…”

Section: Herbal Remedies Of Male Fertility/infertility Issuesmentioning

confidence: 99%

See 1 more Smart Citation

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Akour

Kasabri

Afifi

et al. 2016

Pharmaceutical Biology

View full text Add to dashboard Cite

Context National statistical reports in Jordan indicate a decrease in the total fertility rate along with a parallel increase in contraceptive use. The folkloric use of medicinal herbs in gynecological disorders has been growing in Jordan, despite of deficient reports on the evidence-based safety and efficacy of these practices. Objective The aim of this comprehensive article is to review medicinal plants with claimed ethnonpharmacological usage in various gynecological and pregnancy-related issues in Jordan, and to assess their evidence-based pharmacological studies as well as their phytochemistry. Methods The published literature was surveyed using Google Scholar entering the terms ''ethnopharmacology AND Jordan AND infertility AND gynecology OR gestation''. We included ethnopharmacological surveys in Jordan with available full-text. Results Twelve articles were reviewed. Plant species which are commonly used for female gynecological issues such as Artemisia monosperma Del. and A. herba-alba Asso. (Asteraceae) have been found to exert an antifertility effect. Ricinus communis L. (Euphorbiaceae) and Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) had antifertility effects in male rats, but Nigella sativa oil L. (Ranunculaceae) and Cinnamon zeylanicum J. Presl (Lauraceae) were found to enhance it. Conclusion Using plants for gynecological disorders is a common practice in Jordan. Many of them, whether utilised for gynecological or non-gynecological conditions equally, were found to have detrimental effects on female or male fertility. Thus, couples planning pregnancy should be discouraged from the consumption of these herbs. Further local studies are warranted to confirm the appreciable beneficial pharmacological effects and safety of these plants. ARTICLE HISTORY

show abstract

“…Daily intake of N. sativa oil for 2-3 months improved abnormal semen quality in infertile men without any adverse effects (Kolahdooz et al 2014). …”

Section: Herbal Remedies With Female Antifertility and Abortificiant mentioning

confidence: 99%

Section: Herbal Remedies Of Male Fertility/infertility Issuesmentioning

confidence: 99%

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Akour

Kasabri

Afifi

et al. 2016

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…In addition, TQ alerted the events produced by methotrexate such as intestinal space dilatation, edema, disruption in the somniferous epithelium and reduced diameter of the semniferous tubules. Moreover, infertile men (n = 34) when treated with 2.5 mL NS oil for 2 months, significantly improved abnormal semen quality without producing any adverse effect [35]. According to Mahdavi et al [36] the NS oil is a good candidate for treating male infertility.…”

Section: Effects On Reproductive Systemmentioning

confidence: 97%

A comprehensive and updated review on the pharmacological activities and phytochemistry of Nigella sativa L.

Islam¹

2016

Adv. Biomed. Pharma.

View full text Add to dashboard Cite

Nigella sativa L. (NS) has a number of important biological activities, such as antioxidant, anti-inflammatory, antibacterial, antifungal, anti-viral, anti-parasitic and anti-protozoal, cytotoxic, anticancer, neuro-, gastro-, cardio-, hetapto-and nephroprotective activities. In addition, the NS exerts beneficiary effects on reproductive, pulmonary and immune systems as well as in diabetes mellitus (DM), fertility (male and female), breast cancer, dermatological complications, dehydration, dyspepsia, and osmotic balance and so on. Among the isolated constituents, thymoquinone (TQ) is a vastly studied phytochemical in NS. A number of reports suggest that, the NS may be one of the potential herbs in health promotion. This review paper will discuss the detailed and mechanistic aspects of the biological activity of N. sativa along with the reported phytoconstituents.

show abstract

“…The evidences of its therapeutic efficacies span decades of scientific literature and includes broncho-dilatation, immune-modulation (18), antibacterial (19), hypotension (20), anti-diabetic (21), hepatoprotective (22), gastro protective (23), antihistaminic and anti-oxidative (24,25), neuroprotective (26,27) and tumour suppressive (28). Plants extracts are also used as memory enhancement (29,30), infertility improvement in men (31) and efficacy in neurodegenerative diseases and disorders (32,33).…”

Section: Introductionmentioning

confidence: 99%

Histopathological and Biochemical evaluations of the antidotal efficacy of <i>Nigella sativa</i> oil on organophosphate induced hepato-toxicity

Ajao¹,

Abdussalam²,

Imam³

et al. 2017

Research Journal of Health Sciences

View full text Add to dashboard Cite

Objective: The study was designed to investigate the effects of continuous exposure of dichlorvos (DDVP) on hepatic function and hepatic histomorphology, with the possible antidotal efficacy of Nigella sativa oil (NSO).Methods: Twenty four Wistar rats were randomly divided into four groups, with each group comprising of six rats. The groups were labelled as Sunflower oil (SFO), DDVP, DDVP+NSO and NSO. After 14 days of treatments, blood samples were collected, centrifuged and levels of ALP (Alkaline phosphatase), ALT (Alanine aminotransferase), AST (Aspartate aminotransferase) and GGT (γ-glutamyl-transferase) concentrations were estimated in the serum. The livers were removed and prepared for histopathological examinations and evaluation. Results:The findings of the study shows significant increase in the serum concentration of ALT, ALP, AST and GGT with a marked distortion in the hepatic architecture in rats administered with DDVP. However, Nigella sativa oil (NSO) was observed to ameliorate the levels of impairment in the assessed hepatic function parameters and relatively restoration in the hepatic architecture in DDVP+NSO treated animals when compared to the control and group administered with DDVP only. Conclusion:The study concludes that impaired liver functions and histomorphological tissue distortions observed in the experimental rats following DDVP exposure were ameliorated following the administration of NSO.

show abstract

Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: A randomized, double-blind, placebo-controlled clinical trial

Cited by 103 publications

References 18 publications

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

A comprehensive and updated review on the pharmacological activities and phytochemistry of Nigella sativa L.

Histopathological and Biochemical evaluations of the antidotal efficacy of <i>Nigella sativa</i> oil on organophosphate induced hepato-toxicity

Contact Info

Product

Resources

About