Effects of nicotinic agonists on the NMDA receptor

Aizenman, Elias; Tang, Lian-Hong; Reynolds, Ian J.

doi:10.1016/0006-8993(91)90958-x

Cited by 50 publications

(24 citation statements)

References 13 publications

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“…These data suggest that SIB-1553A effects are specific to the attentional disruptions induced by dizocilpine, and not to the disruption of response sequence or behavioral inhibition. It is therefore unlikely that SIB-1553A acts through direct competition at the NMDA receptor (Aizenman et al, 1991) because SIB-1553A only attenuated the effects of dizocilpine on accuracy, and had no effect on dizocilpine-induced increases in inappropriate responding.…”

Section: Discussionmentioning

confidence: 99%

Effects of (±)-4-{[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio}phenol Hydrochloride (SIB-1553A), a Selective Ligand for Nicotinic Acetylcholine Receptors, in Tests of Visual Attention and Distractibility in Rats and Monkeys

Terry

Risbrough

Buccafusco

et al. 2002

J Pharmacol Exp Ther

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Nicotine, a nonselective ligand for nicotinic acetylcholine receptors (nAChRs), has been shown to improve attention and reduce distractibility in humans. Although the numerous side effects induced by nicotine prevent its use as a therapeutic agent, it is hypothesized that subtype-selective nAChR ligands may offer a potential therapeutic benefit to humans with attention deficits. In this study, we evaluated the attention-enhancing properties of (Ϯ)-4-{[2-(1-methyl-2-pyrrolidinyl)ethyl]thio}phenol hydrochloride (SIB-1553A), a ligand selective for neuronal nAChRs with predominant activity at the human ␤4 subtype. SIB-1553A was evaluated in a test of attention (i.e., five-choice serial reaction time task or SRTT) and distractibility (i.e., delayed matching to sample task with distractor or DMTS-D) in adult rats and monkeys, respectively. SIB-1553A did not improve SRTT performance in normal rats, but reversed deficits induced by the N-meth-

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Section: Discussionmentioning

confidence: 99%

Effects of (±)-4-{[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio}phenol Hydrochloride (SIB-1553A), a Selective Ligand for Nicotinic Acetylcholine Receptors, in Tests of Visual Attention and Distractibility in Rats and Monkeys

Terry

Risbrough

Buccafusco

et al. 2002

J Pharmacol Exp Ther

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“…Nicotine has been found to bind to specifically NMDA receptors (Snell and Johnson 1989;Aizenman et al 1991). Some mecamylamine effects may be mediated via its blockade of NMDA receptors (MacLeod et al 1984;O'Dell and Christensen 1988;Snell and Johnson 1989).…”

Section: Other Transmitter Systemsmentioning

confidence: 99%

Nicotinic systems and cognitive function

1992

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Nicotinic acetylcholine receptors have been found to be important for maintaining optimal performance on a variety of cognitive tasks. In humans, nicotine-induced improvement of rapid information processing is particularly well documented. In experimental animals nicotine has been found to improve learning and memory on a variety of tasks, while the nicotinic antagonist mecamylamine has been found to impair memory performance. Nicotine has been found to be effective in attenuating memory deficits resulting from lesions of the septohippocampal pathway or aging in experimental animals. Nicotinic receptors are decreased in the cortex of patients with Alzheimer's disease. Preliminary studies have found that some aspects of the cognitive deficit in Alzheimer's disease can be attenuated by nicotine. Nicotine may prove to be useful therapeutic treatment for this and other types of dementia.

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“…Nicotine seems to exert these varying effects by acting on different neurotransmitters and pathways in the brain, such as the glutamatergic system (Mathalon et al 2014;Zarrindast et al 2012). Past studies showed that nicotine can block N-Methyl-D-aspartate (NMDA) receptors in the CNS of rodents (Aizenman et al 1991). However, other experiments have shown the synergic effect of NMDA receptors and nicotine (Aramakis and Metherate 1998;Shim et al 2002).…”

Section: Introductionmentioning

confidence: 98%