Effects of nicotine on cellular function in UMR 106-01 osteoblast-like cells☆

Fang, Mengyuan; Frost, Patrick; Iida-Klein, Akiko; Hahn, Theodore J.

doi:10.1016/8756-3282(91)90077-v

Cited by 183 publications

(103 citation statements)

References 14 publications

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“…The reduced serum osteocalcin levels in smokers might indicate a decreased osteoblastic activity. This is in agreement with in vitro studies that have shown a direct toxic effect of tobacco on osteoblasts (Fang et al, 1991). No differences were seen in total serum alkaline phosphatase.…”

Section: Discussionsupporting

confidence: 92%

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The influence of smoking on vitamin D status and calcium metabolism

1999

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Objective: To assess the in¯uence of smoking on serum parathyroid hormone (PTH), serum vitamin D metabolites, serum ionized calcium, serum phosphate, and biochemical markers of bone turnover in a cohort of 510 healthy Danish perimenopausal women. Design: A cross-sectional study. Setting: Copenhagen, Denmark. Subjects: Five-hundred-and-ten healthy women aged 45 ± 58 y, included 3 ± 24 months after last menstrual bleeding. None were using hormone replacement therapy. Methods: The women were grouped according to their current smoking status. The two groups were compared with regard to serum levels of 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25-(OH) 2 D), intact PTH, ionized calcium and phosphate, osteocalcin, as well as urine pyridinolines. Bone mineral density (BMD) was measured with DEXA-scans. Multiple regression analyses were performed to detect the effect of potentially confounding lifestyle factors, such as calcium and vitamin D intakes, alcohol and coffee consumption, sunbathing, and physical exercise. Results: Fifty percent were current smokers. Smokers had signi®cantly reduced levels of serum 25OHD (P 0.02), 1,25(OH) 2 D (P 0.001), and PTH (P`0.001). There was no difference in serum ionized calcium between smokers and non-smokers. We found a negative effect of smoking on serum osteocalcin (P 0.01), while urinary pyridinolines were similar in the two groups. The small differences in lifestyle between the two groups could not explain these ®ndings. Smokers had small but signi®cant reductions in bone mineral density. Conclusions: Smoking has a signi®cant effect on calcium and vitamin D metabolism, which is not likely to be explained by other confounding lifestyle factors. The depression of the vitamin D-PTH system seen among smokers may represent another potential mechanism for the deleterious effects of smoking on the skeleton, and may contribute to the reported risk of osteoporosis among smokers.

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Section: Discussionsupporting

confidence: 92%

“…Other lifestyle factors are regarded as more prevalent among smokers compared to nonsmokers such as less physical activity, increased alcohol intake, or associated nutritional de®ciencies, all of which might play a role. A direct toxic effect of tobacco smoking on bone cells is also a possibility (Fang et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

The influence of smoking on vitamin D status and calcium metabolism

1999

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“…The effect of IL-6 on osteoblastic proliferation is less clear. Mitogenic effects of IL-6 on rat osteosarcoma cells have been reported (Fang and Hahn 1991), but this has not been seen in isolated human osteoblasts (Littlewood et al 1991). Another important aspect of these cytokines is their ability to induce prostaglandin formation in osteoblasts (Ellies andAubin 1990, Littlewood et al 1991).…”

Section: Interleukin-1 8 (Il-1 B) and Tumor Necrosis Factor43mentioning

confidence: 99%

Inflammatory cytokines regulate proliferation of cultured human osteoblasts

Frost

Jonsson

Nilsson

et al. 1997

Acta Orthopaedica Scandinavica

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“…In the presence of an arthroscopic surgical procedure, the hypotensive anesthesia required for the procedure incurs greater risks when performed in smoking patients (25) . The vasoconstriction caused by nicotine may affect the postoperative healing process (11) .…”

Section: Discussionmentioning

confidence: 99%

“…Smoking causes vasoconstriction, reducing peripheral oxygen tension, which in turn, inhibits cell proliferation during healing (11,12) . This anti-physio-logical effect causes a delay of fracture consolidation (13)(14)(15)(16) , increases the incidence of pseudarthrosis in the humerus (17) and is reported in the literature as being associated with deep vein thrombosis following shoulder arthroscopy (18) .…”

Section: Introductionmentioning

confidence: 99%