Effects of newly synthesised platinum(II) complexes on mitochondrial functions

Beltrame, M.; Sindellari, L.; Arslan, Paola

doi:10.1016/0009-2797(84)90100-5

Cited by 6 publications

(1 citation statement)

References 20 publications

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“…Cisplatin treatment causes an increase in the sensitivity of mitochondria to Ca 2+ ‐induced mitochondrial permeability transition and also interferes with mitochondrial bioenergetics by increasing mitochondrial inner membrane permeabilization to H + [23]. Mitochondria play a central role in cellular homeostasis and platinum (II) complexes interact with energy‐dependent functions in the cells [24]. Cisplatin induces apoptosis through activation of mitochondrial signaling pathways, in which the sequence of events may involve activation of Bax inducing mitochondrial permeability transition, leading to release of cytochrome c, activation of caspase‐9, and entry into the execution phase of apoptosis [25].…”

Section: Introductionmentioning

confidence: 99%

Cisplatin‐ and dietary ascorbic acid‐mediated changes in the mitochondria of Dalton’s lymphoma‐bearing mice

Martha

Rosangkima

Amenla

et al. 2011

Fundamemntal Clinical Pharma

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Cisplatin treatment caused a significant increase in the life span of ascites Dalton's lymphoma (DL) Tumor-bearing (TB) mice. However, as compared to cisplatin (CP) alone, combination treatment with ascorbic acid plus CP resulted in better therapeutic efficacy against murine DL. Cisplatin treatment of TB mice resulted in the appearance of thickened and irregular arrangement of mitochondrial cristae in the liver, kidney and DL tumor cells. Combination treatment of the hosts with ascorbic acid and CP lessened deformities in the mitochondria of liver and kidney, while in tumor cells, this increased the formation of vacuoles and disruption in mitochondrial cristae. Cisplatin treatment decreased the succinate dehydrogenase (SDH) activity in the mitochondria of kidney and DL cells and combination treatment caused further decrease in SDH activity in kidney and DL cells during 24-48 h of treatment. After CP treatment, the protein content in the mitochondria of these tissues decreased, and during combination treatment, it showed significant improvement. Mitochondrial lipid peroxidation (LPO) increased in these tissues after CP treatment. However, combination treatment significantly decreased mitochondrial LPO in liver and kidney but increased in DL cells. This increase in mitochondrial LPO in DL cells and decrease in liver and kidney could play an important role in the antitumor activity of combination treatment and at the same time reduce CP-induced toxicity in the host. However, further study may be desirable to explore some aspects of the mechanism(s) involved in these changes in mitochondria.

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Section: Introductionmentioning

confidence: 99%

Cisplatin‐ and dietary ascorbic acid‐mediated changes in the mitochondria of Dalton’s lymphoma‐bearing mice

Martha

Rosangkima

Amenla

et al. 2011

Fundamemntal Clinical Pharma

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Platinum—Amine Complexes as Anticancer Agents

Farrell

1989

Transition Metal Complexes as Drugs and Chemotherapeutic Agents

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Differential effects of cisplatin on mouse hepatic and renal mitochrondrial DNA

1990

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The objective of this study was to determine if the nephrotoxic effects induced by cisplatin were correlated to mitochondrial DNA damage. Comparisons were made with the liver since hepatotoxicity is rarely observed. Cisplatin doses of 10, 20 and 40 mg/kg were administered intraperitoneally to C57BL/6J mice. Mitochondrial DNA was isolated from both the hepatic and renal tissues and quantitated by hybridization with a specific mitochondrial probe. Cisplatin caused differential effects on mouse hepatic and renal mitochondrial DNA. The 10 and 20 mg/kg dose caused an elevation in mitochondrial DNA levels in the hepatic, but no increase in the renal tissue was observed. This is the first study demonstrating an organ specific effect of cisplatin at the DNA level.

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Effects of newly synthesised platinum(II) complexes on mitochondrial functions

Cited by 6 publications

References 20 publications

Cisplatin‐ and dietary ascorbic acid‐mediated changes in the mitochondria of Dalton’s lymphoma‐bearing mice

Cisplatin‐ and dietary ascorbic acid‐mediated changes in the mitochondria of Dalton’s lymphoma‐bearing mice

Platinum—Amine Complexes as Anticancer Agents

Differential effects of cisplatin on mouse hepatic and renal mitochrondrial DNA

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