Effects of neural mobilization in disorders associated with chronic secondary musculoskeletal pain: A systematic review and meta-analysis

González-Matilla, Ramón; Abuín-Porras, Vanesa; Casuso-Holgado, María Jesús; Riquelme, Inmaculada; Heredia-Rizo, Alberto Marcos

doi:10.1016/j.ctcp.2022.101618

Cited by 3 publications

(5 citation statements)

References 48 publications

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“…[93][94][95][96] For functional status and cervical range of motion, there were no significant differences between groups, which agrees with the findings of Varangot-Reille et al 19 It was not possible to perform meta-analyses for the other musculoskeletal conditions and outcomes, such as pressure pain threshold and muscle strength, which limits the conclusions to be drawn. González-Matilla et al 18 identified an effectiveness of neural mobilisation when compared to joint mobilisation and exercises for pain intensity in people with autoinflammatory diseases (hand osteoarthritis and rheumatoid arthritis), but they showed a pooled global effect for both conditions. 87 Our analyses revealed no statistical significance for pain improvement in any of these conditions individually.…”

Section: Discussionmentioning

confidence: 99%

“…• Population -People over 18 We searched for articles published until June 2023 in the data sources described in Table 1. The search was performed by one reviewer (FB).…”

Section: Methodsmentioning

confidence: 99%

“…Previous reviews have investigated the effectiveness of neural mobilisation mainly in nerverelated musculoskeletal disorders, 8,[15][16][17][18][19] but evidence on its effectiveness in musculoskeletal pain conditions without neurological impairments, as well as in aspects of physical performance, is sparse. Thus, this systematic review aims to investigate up-to-date evidence on the effectiveness of neural mobilisation techniques in improving pain, function, and physical performance in people with different musculoskeletal pain conditions without neurological deficits.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Neural Mobilisation on Pain Intensity, Functional Status, and Physical Performance in Adults with Musculoskeletal Pain – A Systematic Review with Meta-Analysis

Baptista,

Nery,

Cruz

et al. 2023

Clin Rehabil

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Objective To investigate up-to-date evidence of the effectiveness of neural mobilisation techniques compared with any type of comparator in improving pain, function, and physical performance in people with musculoskeletal pain. Data sources The following sources were consulted: PubMed, Web of Science, CENTRAL, CINAHL, Scopus, and PEDro databases; scientific repositories; and clinical trial registers. The last search was performed on 01/06/2023. Methods Two reviewers independently assessed the studies for inclusion. We included randomised, quasi-randomised, and crossover trials on musculoskeletal pain in which at least one group received neural mobilisation (alone or as part of multimodal interventions). Meta-analyses were performed where possible. The RoB 2 and the Grading of Recommendations Assessment, Development and Evaluation tools were used to assess risk of bias and to rate the certainty of evidence, respectively. Results Thirty-nine trials were identified. There was a significant effect favouring neural mobilisation for pain and function in people with low back pain, but not for flexibility. For neck pain, there was a significant effect favouring neural mobilisation as part of multimodal interventions for pain, but not for function and range of motion. Regarding other musculoskeletal conditions, it was not possible to conclude whether neural mobilisation is effective in improving pain and function. There was very low confidence for all effect estimates. Conclusions Neural mobilisation as part of multimodal interventions appears to have a positive effect on pain for patients with low back pain and neck pain and on function in people with low back pain. For the other musculoskeletal conditions, results are inconclusive.

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Section: Discussionmentioning

confidence: 99%

“…• Population -People over 18 We searched for articles published until June 2023 in the data sources described in Table 1. The search was performed by one reviewer (FB).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Neural Mobilisation on Pain Intensity, Functional Status, and Physical Performance in Adults with Musculoskeletal Pain – A Systematic Review with Meta-Analysis

Baptista,

Nery,

Cruz

et al. 2023

Clin Rehabil

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“…These joints are often affected by osteoarthritis, a degenerative condition that causes deterioration of the joint surfaces and eventual bone modeling. The consequence of such a condition is severe pain, leading to significant functional limitations and disability, as well as a significant social burden. − Patients with osteoarthritis represent the cohort of people with upper limb osteoarthritis most likely to undergo surgical intervention . However, previous studies evaluating the efficacy of surgical intervention have shown varying levels of benefit in terms of pain reduction and improved function and have reported adverse event rates ranging from 10 to 22%, depending on the procedure used .…”

Section: Introductionmentioning

confidence: 99%

“…1−4 Patients with osteoarthritis represent the cohort of people with upper limb osteoarthritis most likely to undergo surgical intervention. 5 However, previous studies evaluating the efficacy of surgical intervention have shown varying levels of benefit in terms of pain reduction and improved function and have reported adverse event rates ranging from 10 to 22%, depending on the procedure used. 6 Therefore, it is important to identify the most effective management strategies to improve pain and function in the osteoarthritis population.…”

Section: ■ Introductionmentioning

confidence: 99%

Evaluation of In Vivo Biocompatibility in Preclinical Studies of a Finger Implant Medical Device Correlated with Mechanical Properties and Microstructure

Major,

Grajoszek,

Byrski

et al. 2023

ACS Appl. Mater. Interfaces

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The aim of the experiment was to evaluate the biocompatibility of four 3D-printed biomaterials planned for use in the surgical treatment of finger amputees: Ti-6Al-4 V (Ti64), ZrO 2 −Al 2 O 3 ceramic material (ATZ20), and osteoconductive (anodized Ti64) and antibacterial (Hydroxyapatite, HAp) coatings that adhere well to materials dedicated to finger bone implants. The work concerns the correlation of mechanical, microstructural, and biological properties of dedicated materials. Biological tests consisted of determining the overall cytotoxicity of the organism on the basis of in vivo tests carried out in accordance with the ISO 10993-6 and ISO 10993-11 standards. Clinical observations followed by diagnostic examinations, histopathological evaluation, and biochemical characterization showed no significant differences between control and tested groups of animals. The wound healed without complication, and no pathological effects were found. The wear test showed the fragility of the hydroxyapatite thin layer and the mechanical stability of the zirconia-based ceramic substrate. Electron microscopy observations revealed the layered structure of tested substrates and coatings.

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Efficacy of neuromobilization in the treatment of low back pain: Systematic review and meta-analysis

Chen,

Wang,

Chen

et al. 2024

PLoS ONE

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Background Low back pain (LBP) is a leading cause of disability. Neuromobilization (NM) as a physical therapy technique, offers some degree of symptom improvement. However, some studies have shown that NM can significantly reduce the symptoms of LBP, while others have failed to find similar positive effects. Objective This study aims to investigate the effectiveness of NM for LBP. Data sources A literature search was conducted across five databases (MEDLINE, Embase, Cochrane Library, PubMed, and Web of Science) from their inception to December 2023. Study main measures assessed pain, disability, and straight leg raise angle to determine the degree of improvement in patients. Results Seven randomized controlled trials were included in the analysis. The findings indicated that NM interventions in patients with LBP were more effective than control groups in improving Visual Analog Scale scores (mean difference = 0.62, 95% CI (0.03, 1.21)) and Oswestry Disability Index scores (mean difference = 7.54, 95% CI (4.98, 10.10)). There was no significant difference in straight leg raise results (mean difference = 0.18, 95% CI (-0.08, 0.44)). Conclusions NM demonstrated effectiveness in improving Visual Analog Scale and Oswestry Disability Index outcomes in patients with LBP, but straight leg raise outcomes are still uncertain and until more high-quality studies are included, the effectiveness of NM for SLR remains unknown.

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Effects of neural mobilization in disorders associated with chronic secondary musculoskeletal pain: A systematic review and meta-analysis

Cited by 3 publications

References 48 publications

Effectiveness of Neural Mobilisation on Pain Intensity, Functional Status, and Physical Performance in Adults with Musculoskeletal Pain – A Systematic Review with Meta-Analysis

Effectiveness of Neural Mobilisation on Pain Intensity, Functional Status, and Physical Performance in Adults with Musculoskeletal Pain – A Systematic Review with Meta-Analysis

Evaluation of In Vivo Biocompatibility in Preclinical Studies of a Finger Implant Medical Device Correlated with Mechanical Properties and Microstructure

Efficacy of neuromobilization in the treatment of low back pain: Systematic review and meta-analysis

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