Effects of nerol on paracetamol-induced liver damage in Wistar albino rats

Islam, Muhammad Torequl; Quispe, Cristina; Islam, Md. Amirul; Ali, Eunüs S.; Saha, Subhas Chandra; Asha, Umma Hafsa; Mondal, Milon; Razis, Ahmad Faizal Abdull; Usman, Sunusi; Kamal, Ramla Muhammad; Kumar, Manoj; Sharifi‐Rad, Javad

doi:10.1016/j.biopha.2021.111732

Cited by 43 publications

(42 citation statements)

References 32 publications

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“…The intoxication of paracetamol seems to affect lipoprotein metabolism, resulting in an altered metabolism of cholesterol, which raises serum cholesterol levels. 19 In the present study, the paracetamol-treated group observed with remarkable increase TC in contrast to normal control rats. Group received with ECZ significantly decreased the serum TC.…”

Section: Discussionsupporting

confidence: 45%

“…The effect of ECZ on paracetamol-induced hepatotoxicity in rats was studied by taking five groups, each having six animals. 19 Group-I taken carboxy methyl cellulose (1 % w/v, 2 ml/kg) and considered as normal control; Group-II taken 750 mg/kg of paracetamol and considered as negative control; Group-III taken silymarin (100 mg/kg) and considered as positive control; Group-IV and Group-V taken 200 and 300 mg/kg of ECZ respectively for 7 days. The suspension of paracetamol was administered to all groups except Group-I on day 7.…”

Section: Effect Of Ethanolic Extract Of C Zeylanica On Paracetamol-in...mentioning

confidence: 99%

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Hepatoprotective Potential of Ethanolic Extract of Capparis zeylanica Root on Paracetamol-induced Hepatotoxicity in Rats

Hota¹,

Nanda²,

Behera³

et al. 2022

IJPI

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Background: Capparis zeylanica (Capparaceae), a climbing shrub find its distribution throughout the different parts of India. Traditionally, it is used in the treatment of snake bite, small pox, stomach ulcers, piles, cholera, hepatitis, as liver tonics, rheumatism and inflammation. In the present investigation the hepatoprotective potential of plant was evaluated in paracetamol-induced (750 mg/kg) hepatotoxicity rats. Methods: The animals were treated with 200 and 300 mg/kg of ethanolic extract of C. zeylanica root using silymarin (100 mg/kg) as reference. The liver function enzymes were determined. The estimation of malondialdehyde, superoxide dismutage, catalase and glutathione were performed in liver tissue homogenate. The excised liver was also subjected to histological study. Results: The noticeable declined in aspartate aminotransferase, alanine transaminase, alkaline phosphate, bilirunin and cholesterol and elevating the level of albumin, globulin and protein were observed at 300 mg/kg of drug as compared to 200 mg/kg. The significant decrease in malondialdehyde and increase in superoxide dismutage, catalase and glutathion were noticed in treated group. The periportal hypertrophy, deterioration of hepatic parenchyma, dilation of sinusoidal capillary, central vein and portal vein noticed in hepatotoxicity rats were decreased after administration of extract. Conclusion: The hepatoprotective potential of C. zeylanica root could be assumed due to the synergistic activities of carbohydrates, alkaloids, phenols, flavonoids, steroids and the strong antioxidant activity by flavonoids, phenolics, β-carotene and rutin.

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Section: Discussionsupporting

confidence: 45%

Section: Effect Of Ethanolic Extract Of C Zeylanica On Paracetamol-in...mentioning

confidence: 99%

Hepatoprotective Potential of Ethanolic Extract of Capparis zeylanica Root on Paracetamol-induced Hepatotoxicity in Rats

Hota¹,

Nanda²,

Behera³

et al. 2022

IJPI

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“…Cytochrome p450 complex is a key system for metabolizing APAP and glucuronidation is the main detoxification process for acetaminophen. One of the APAP metabolite known as NAPQI is neutralized through its binding to GSH molecule [33]. High-dose acetaminophen is associated with GSH depletion in the liver tissue with subsequent production of highly reactive and toxic substances such as H2O2 and ROS and ultimate dysfunction of mitochondrial electron transport chain which is mediated through activation of apoptosis signalingregulating kinase (Ask-1), mitogen-activated protein kinase, and c-Jun N-terminal kinase (JNK) pathways [34,35].…”

Section: Discussionmentioning

confidence: 99%

“…Serum levels of transaminase enzymes consisting of ALT and AST somehow indicates health and/or injury of the of liver tissue [33,36]. In this regard, serum elevation of these enzymes is a clinically consistent indicator of liver injury [37].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced Hepatotoxicity through Targeting NLRP3/NF-κB/Nrf2

et al. 2022

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Acetaminophen (APAP)-induced acute liver injury (ALI) is the principal cause of acute liver failure (ALF) in some countries including the United States and with few available treatments. Isorhamnetin is a bioflavonoid that is found in medicinal plants like Hippophae rhamnoides L. and Ginkgo biloba L. with promising potential to regulate inflammatory responses. In this study, we evaluated the possible effect of isorhamnetin in prevention of APAP-induced ALI and analyzed further the involvement of oxidative stress and inflammation-associated factors. Male C57BL/6 mice were given isorhamnetin (25 or 100 mg/kg b.w., p.o.) three times at 48, 24, and 1 h before APAP administration (300 mg/kg b.w., i.p.). Functional indicators of liver injury were measured as well as analysis of oxidative stress- and inflammation-associated indices and liver histopathology was also conducted. Isorhamnetin at the higher dose of 100 mg/kg significantly lowered serum levels of ALT, ALP, and AST in addition to reduction of ROS, TBARS, IL-6, TNFα, NF-kB, NLRP3, caspase 1, and MPO and significantly prevented reduction of GSH, SOD activity, sirtuin 1, and Nrf2. Additionally, isorhamnetin alleviated pathological changes of the liver tissue and suitably reversed NF-kB and Nrf2 immunoreactivity. These findings show protective effect of isorhamnetin against acetaminophen-induced liver injury through reducing oxidative stress, inflammation, and pyroptosis which is attributed to its regulation of NF-kB, Nrf2, NLRP3, and sirtuin 1.

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“…Perubahan pada semua bahan asing atau toksin menjadi bahan yang tidak membahayakan tubuh merupakan proses detoksifikasi dalam hati. Kerusakan dalam hati akan terjadi bila bahan yang berbahaya tersebut dalam jumlah yang banyak dan melebihi kemampuan hati dalam melakukan detoksifikasi (Islam et al, 2021). Contoh sumber kerusakan hati tersebut adalah hepatotoksin.…”

Section: Pendahuluanunclassified

Hepatoprotective Activity of Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in Rats Induced by Paracetamol

Hasan¹,

Setiyono²,

Afrian³

2022

Curr. Biochem.

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Negative effects on health will occur in excessive use of paracetamol. The main objective of this study was to determine the hepatoprotective activity of Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in rats induced by paracetamol. The study was conducted on 36 Sprague Dawley rats with 6 rats in each group. Group 1 (normal control), group 2 (positive control, temulawak 42.86 mg/kg BW), group 3 (negative control), group 4 (infusion of Myrmeleon 10 mg/kg BW), group 5 (propolis extract 0.02 ml/kg BW), and group 6 (Hibiscus sabdariffa infusion 0.02 ml/kg BW). Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations were determined spectrophotometrically and microscopically for liver histopathology. The results showed that during three weeks of treatment with Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in rats, this treatment could decrease ALT and AST activity as the positive control. The ALT activity values of the three materials were 69.26, 51.00, 51.00, 43.67, U/I with AST values of 110.29, 97.33, 91.00, 91.33 U/I. Based on Duncan's test, there were significant differences between all treatments with negative and positive control groups. Likewise, with the histopathological scoring results, the negative control was found to be significantly different from all treatments. Therefore, treatment with propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. may have hepatoprotective benefit.

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Effects of nerol on paracetamol-induced liver damage in Wistar albino rats

Cited by 43 publications

References 32 publications

Hepatoprotective Potential of Ethanolic Extract of Capparis zeylanica Root on Paracetamol-induced Hepatotoxicity in Rats

Hepatoprotective Potential of Ethanolic Extract of Capparis zeylanica Root on Paracetamol-induced Hepatotoxicity in Rats

Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced Hepatotoxicity through Targeting NLRP3/NF-κB/Nrf2

Hepatoprotective Activity of Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in Rats Induced by Paracetamol

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