Effects of neonatal treatment with phytoestrogens, genistein and daidzein, on sex difference in female rat brain function: estrous cycle and lordosis

Kouki, Tom; Kishitake, Miki; Okamoto, Mayumi; Oosuka, Izumi; Takebe, Minoru; Yamanouchi, Korehito

doi:10.1016/s0018-506x(03)00122-3

Cited by 122 publications

(95 citation statements)

References 30 publications

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“…These doses span the range of human exposure levels: a treatment of 50 mg/kg/day resulted in serum genistein levels of 6.8 lM, comparable to the circulating levels of 1.4-4.5 lM found in the serum of infants consuming soy-based formulas (Setchell et al, 1997). Interestingly, similar alterations of the estrous cycle have been observed in other rodents studies involving exposure to EDCs such as genistein, zearalenone, and bisphenol A (Kouki et al, 2003;Nikaido et al, 2004). In addition to the adverse effects on the reproductive tract and ovaries, pregnancy in mice exposed to genistein as neonates was also affected in a dose and timedependent manner (Jefferson et al, 2005).…”

Section: Soy Phytoestrogens and Female Fertilitysupporting

confidence: 66%

“…These include alterations in ovarian development (increased percentage of multi-oocyte follicles (MOFs)), the timing of vaginal opening, estrous cyclicity, ovarian function, HPG axis, subfertility and an increased incidence of uterine adenocarcinoma (Chen et al, 2007;Delclos et al, 2001Delclos et al, , 2009Jefferson et al, 2006Jefferson et al, , 2002Jefferson et al, , 2005Kouki et al, 2003;Lewis et al, 2003;Nagao et al, 2001;Newbold et al, 2001;Nikaido et al, 2004;NTP, 2008). For example, in mice neonatal injection of genistein at doses of 0.5, 5 and 50 mg/kg/day on postnatal days 1-5 leads to prolonged estrous cycles with a dose-dependent and age-related increase in severity (Jefferson et al, 2002).…”

Section: Soy Phytoestrogens and Female Fertilitymentioning

confidence: 99%

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Soy, phytoestrogens and their impact on reproductive health

Cederroth

Zimmermann

Nef

2012

Molecular and Cellular Endocrinology

189

117

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a b s t r a c tThere is growing interest in the potential health threats posed by endocrine-disrupting chemicals (EDCs) to the reproductive system. Soybean is the most important dietary source of isoflavones, an important class of phytoestrogen. While consumption of soy food or phytoestrogen supplements has been frequently associated with beneficial health effects, the potentially adverse effects on development, fertility, and the reproductive and endocrine systems are likely underappreciated. Here we review the available epidemiological, clinical and animal data on the effects of soy and phytoestrogens on the development and function of the male and female reproductive system, and weigh the evidence as to their detrimental impact.

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Section: Soy Phytoestrogens and Female Fertilitysupporting

confidence: 66%

Section: Soy Phytoestrogens and Female Fertilitymentioning

confidence: 99%

Soy, phytoestrogens and their impact on reproductive health

Cederroth

Zimmermann

Nef

2012

Molecular and Cellular Endocrinology

189

117

View full text Add to dashboard Cite

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“…Aberrations in mating behavior of female rats have also been shown for phytoestrogens such as soy, reported by Patisaul et al [114]. Early postnatal treatment with relatively high-dose coumestrol also inhibited lordosis behavior in adulthood [84], and postnatal treatment with genistein reduced the lordosis quotient [83]. Moniz et al [103] reported that perinatal exposure (day 18 of gestation and postnatal days 1 through 5) to the pyrethroid insecticide fenvalerate significantly reduced the lordosis quotient in female rats as adults.…”

Section: Physiological and Behavioral Outcomes Of Neonatal Edc Imprinmentioning

confidence: 87%

Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems

Gore¹

2008

Frontiers in Neuroendocrinology

230

122

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The ability of a species to reproduce successfully requires the careful orchestration of developmental processes during critical time points, particularly the late embryonic and early postnatal periods. This article begins with a brief presentation of the evidence for how gonadal steroid hormones exert these imprinting effects upon the morphology of sexually differentiated hypothalamic brain regions, the mechanisms underlying these effects, and their implications in adulthood. Then, I review the evidence that aberrant exposure to hormonally-active substances such as exogenous endocrine-disrupting chemicals (EDCs), may result in improper hypothalamic programming, thereby decreasing reproductive success in adulthood. The field of endocrine disruption has shed new light on the discipline of basic reproductive neuroendocrinology through studies on how early life exposures to EDCs may alter gene expression via non-genomic, epigenetic mechanisms, including DNA methylation and histone acetylation. Importantly, these effects may be transmitted to future generations if the germline is affected via transgenerational, epigenetic actions. By understanding the mechanisms by which natural hormones and xenobiotics affect reproductive neuroendocrine systems, we will gain a better understanding of normal developmental processes, as well as to develop the potential ability to intervene when development is disrupted.

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“…ERβ-selective phytoestrogens (e.g. genistein, daidzien, coumestrol) attenuate sexual receptivity of female rodents when administered neonatally [84][85]. Other studies in support of the idea that some of these functional effects of E 2 may involve integrated actions of ERα and ERβ are those in which both receptors are expressed.…”

Section: The Role Of Erα (And Erβ) For Functional Effects Of Estogensmentioning

confidence: 99%

Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen

Walf

Frye

2008

Steroids

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The steroid hormone, estradiol (E 2 ), has numerous targets in the central nervous system, including the hippocampus, which plays a key role in cognition and affective behavior. This review focuses on our evidence from studies in rodents that E 2 has diverse mechanisms in the hippocampus for its functional effects E 2 has rapid, membrane-mediated effects in the hippocampus to enhance cognitive performance. Administration of E 2 to the hippocampus of rats for 10 minutes following training enhances performance in a hippocampus-mediated task. Increased cell firing in the hippocampus occurs within this short time frame. Furthermore, administration of free E 2 or an E 2 conjugate, E 2 :bovine serum albumin (BSA), to the hippocampus produces similar performance-enhancing effects in this task, suggesting that E 2 has membrane actions in the hippocampus for these effects. Further evidence that E 2 has rapid, membrane-mediated effects is that co-administration of E 2 and inhibitors of mitogen activated protein kinase (MAPK), rather than intracellular E 2 receptors (ERs) or protein synthesis, attenuate the enhancing effects of E 2 in this task. Despite these data that demonstrate E 2 can have rapid and/or membrane-mediated effects in the hippocampus, there is clear evidence to suggest that intracellular ERs, particularly the β (rather than α) isoform of ERs, may be important targets for E 2 's functional effects for hippocampal processes. Administration of ligands that are specific for ERβ, but not ERα, have enhancing effects on hippocampal processes similar to that of E 2 (which has similar affinity for ERα and ERβ). These effects are attenuated when ERβ expression is knocked down in transgenic models or with central administration of antisense oligonucleotides. Thus, there may be a convergence of E 2 's actions through rapid, membranemediated effects and intracellular ERs and in the hippocampus for these functional effects.

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Effects of neonatal treatment with phytoestrogens, genistein and daidzein, on sex difference in female rat brain function: estrous cycle and lordosis

Cited by 122 publications

References 30 publications

Soy, phytoestrogens and their impact on reproductive health

Soy, phytoestrogens and their impact on reproductive health

Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems

Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen

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