Effects of Natural Phenolic Acids on the Skeletal System of Ovariectomized Rats

Abstract

Recent reports indicate the possibility of antiresorptive and/or bone formation increasing activity of natural phenolic acids, commonly present in plants which are normally consumed in the diet. The effects of 4 natural phenolic acids (ferulic, caffeic, P-coumaric or chlorogenic, 10 mg/kg P. O. daily for 4 weeks) on the skeletal system of ovariectomized (estrogen-deficient) rats were investigated. Bone mass, mineral and calcium content, macrometric and histomorphometric parameters, and mechanical properties were examined. Phenolic acids differentially affected the skeletal system of rats with osteoporotic changes induced by the ovariectomy. Caffeic acid decreased bone mass, whereas P-coumaric acid increased the bone mass/body mass ratio and bone mineral mass/body mass ratio in the long bones, in comparison with the ovariectomized control rats. The phenolic acids improved some bone histomorphometric parameters, impaired by estrogen deficiency. However, they did not increase the ratio of bone mineral mass to bone mass, decreased by estrogen deficiency, and did not significantly affect bone mechanical properties. In conclusion, different natural phenolic acids exert differential effects on the skeletal system of ovariectomized rats, both favourable and deleterious.

Reciprocal Regulation of Adipocyte and Osteoblast Differentiation of Mesenchymal Stem Cells byEupatorium japonicumPrevents Bone Loss and Adiposity Increase in Osteoporotic Rats

“…28,29 Those studies are consistent with our assumption that coumaric acid and its derivatives would mediate pro-bone and anti-fat effects of E. japonicum. To test this possibility directly, we treated cells with coumaric acid or coumaric acid methyl ester and examined their ability to inhibit adipocyte differentiation and promote osteoblast differentiation (Fig.…”

“…Interestingly, coumaric acid was shown to prevent high-fat diet induced obesity in mice as well as bone loss in OVX rats. 28,29 In addition, our data also show that both coumaric acid and coumaric acid methyl ester inhibited lipid accumulation but conversely stimulated ALP activity. Although we cannot exclude the possibility of additive or synergistic effects by combination with other compounds such as thymol and rutin, these data support the idea that coumaric acid and coumaric acid methyl ester can at least in part mediate the anti-fat and pro-bone effects of E. japonicum.…”

The Effect of Coumaric Acid on Ischemia–Reperfusion Injury of Sciatic Nerve in Rats

“…In another study on rats, CA was shown to have a protective effect against the recurrent inflammation of the small intestine induced by dextran sodium sulfate [6]. It has also been shown that CA ameliorates osteoporosis due to estrogen deficiency in rats [17]. Because of its strong tyrosine kinase inhibition activity, CA inhibits melanin synthesis; therefore, it is also considered a kind of antimelanogenic agent [18].…”

Laser-induced carotid artery injury model in the rat for therapeutic agent screening

“…Many studies have indicated that ferulic acid has antioxidant effects, photoprotective effects and antitumor activity, and protects against amyloid peptide toxicity [23][24][25][26][27][28][29][30][31][32][33]. In addition, it has been shown to have antihypertensive activity in spontaneously hypertensive rats.…”