Reciprocal Regulation of Adipocyte and Osteoblast Differentiation of Mesenchymal Stem Cells by<i>Eupatorium japonicum</i>Prevents Bone Loss and Adiposity Increase in Osteoporotic Rats

Kim, Minji; Jang, Woo-Seok; Lee, In‐Kyoung; Kim, Jong Keun; Seong, Ki-Seung; Seo, Cho-Rong; Song, No-Joon; Bang, Min-Hyuk; Lee, Young Min; Kim, Haeng Ran; Park, Ki-Moon; Park, Kye Won

doi:10.1089/jmf.2013.3056

Cited by 11 publications

(7 citation statements)

References 34 publications

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“…Besides, it prevented body weight increase and bone mineral density decrease in ovariectomized rats. Those effects were partially due to the biological activities of this phenolic compound[136]. Similar results showed that p -coumaric acid inhibited adipogenic differentiation of 3T3-L1 preadipocytes[137,138].…”

Section: Effects Of Unsaponifiable Fraction Of Olive Oil In Mscsmentioning

confidence: 78%

Influence of olive oil and its components on mesenchymal stem cell biology

Casado-Díaz¹,

Dorado²,

Quesada‐Gómez³

2019

WJSC

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Extra virgin olive oil is characterized by its high content of unsaturated fatty acid residues in triglycerides, mainly oleic acid, and the presence of bioactive and antioxidant compounds. Its consumption is associated with lower risk of suffering chronic diseases and unwanted processes linked to aging, due to the antioxidant capacity and capability of its components to modulate cellular signaling pathways. Consumption of olive oil can alter the physiology of mesenchymal stem cells (MSCs). This may explain part of the healthy effects of olive oil consumption, such as prevention of unwanted aging processes. To date, there are no specific studies on the action of olive oil on MSCs, but effects of many components of such food on cell viability and differentiation have been evaluated. The objective of this article is to review existing literature on how different compounds of extra virgin olive oil, including residues of fatty acids, vitamins, squalene, triterpenes, pigments and phenols, affect MSC maintenance and differentiation, in order to provide a better understanding of the healthy effects of this food. Interestingly, most studies have shown a positive effect of these compounds on MSCs. The collective findings support the hypothesis that at least part of the beneficial effects of extra virgin olive oil consumption on health may be mediated by its effects on MSCs.

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Section: Effects Of Unsaponifiable Fraction Of Olive Oil In Mscsmentioning

confidence: 78%

Influence of olive oil and its components on mesenchymal stem cell biology

Casado-Díaz¹,

Dorado²,

Quesada‐Gómez³

2019

WJSC

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“…We previously identified several herbal extracts with pro- or anti-adipogenic activities in C3H10T1/2 cells [ 24 ]. From this screening, we recognized Chloranthus japonicus as a possible pro-adipogenic herbal product.…”

Section: Resultsmentioning

confidence: 99%

Hexane Extract of Chloranthus japonicus Increases Adipocyte Differentiation by Acting on Wnt/β-Catenin Signaling Pathway

Yun

Nho²,

Park

et al. 2021

Life

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Chloranthus japonicus has been heavily investigated for the treatment of various diseases. This paper attempts to show that Chloranthus japonicus can modulate adipocyte differentiation of preadipocytes. To establish this, we investigated the effects of Chloranthus japonicus extract in peroxisome proliferator-activated receptor γ (PPARγ) expression, adipogenesis, and the underlying molecular mechanisms in C3H10T1/2 and 3T3-L1 cells. Our data showed that Chloranthus japonicus methanol extract increased lipid accumulation and promoted adipocyte differentiation. Further studies on the fractionation with various solvents led to the identification of Chloranthus japonicus hexane extract (CJHE) as the most potent inducer of adipocyte differentiation. CJHE consistently increased lipid accumulation and adipocyte marker expression including Pparγ and it acted during the early stages of adipocyte differentiation. Mechanistic studies revealed that CJHE and a Wnt inhibitor similarly stimulated adipogenesis and were active in Wnt-selective reporter assays. The effects of CJHE were inhibited by Wnt3a protein treatment and were significantly blunted in β-catenin-silenced cells, further suggesting that CJHE acted on Wnt pathways to promote adipogenesis. We also showed that Chloranthus japonicus extracts generated from different plant parts similarly promoted adipocyte differentiation. These results identified Chloranthus japonicus as a pro-adipogenic natural product and suggest its potential use in metabolic syndrome.

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“…Previous studies reported that Atf3 takes parts in causing insulin resistance, irrespective of obesity (Qi et al ., 2009; Favre et al ., 2011). Atf3 was also suggested to be a part of stimulating inflammation, beta cell apoptosis, and adipokine expression in insulin-resistant adipose tissues (Hartman et al ., 2004; Hai et al ., 2010; Kim et al ., 2014b; Nguyen et al ., 2016). By contrast, other studies have shown that Atf3 is a protective player against glucose intolerance in HFD-fed mice and that Atf3 prevents obesity and improves lipid metabolism in flies (Zmuda et al ., 2010; Rynes et al ., 2012).…”

Section: Discussionmentioning

confidence: 99%

“…It is also possible that Atf3 play differential roles in different metabolic tissues as Atf3 has been shown to play a dichotomous role in breast cancer cells (Yin et al ., 2008). Atf3 expression is ubiquitous and thus it may mediate tissue specific functions in various tissues (Hartman et al ., 2004; Hai et al ., 2010; Kim et al ., 2014b; Nguyen et al ., 2016). As such, the adipose-specific role of Atf3 by generating fat-specific knockout mice should be addressed.…”

Section: Discussionmentioning

confidence: 99%

Sulfuretin Prevents Obesity and Metabolic Diseases in Diet Induced Obese Mice

Kim

Song

Chang

et al. 2019

Biomolecules & Therapeutics

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The global obesity epidemic and associated metabolic diseases require alternative biological targets for new therapeutic strategies. In this study, we show that a phytochemical sulfuretin suppressed adipocyte differentiation of preadipocytes and administration of sulfuretin to high fat diet-fed obese mice prevented obesity and increased insulin sensitivity. These effects were associated with a suppressed expression of inflammatory markers, induced expression of adiponectin, and increased levels of phosphorylated ERK and AKT. To elucidate the molecular mechanism of sulfuretin in adipocytes, we performed microarray analysis and identified activating transcription factor 3 (Atf3) as a sulfuretin-responsive gene. Sulfuretin elevated Atf3 mRNA and protein levels in white adipose tissue and adipocytes. Consistently, deficiency of Atf3 promoted lipid accumulation and the expression of adipocyte markers. Sulfuretin's but not resveratrol's anti-adipogenic effects were diminished in deficient cells, indicating that is an essential factor in the effects of sulfuretin. These results highlight the usefulness of sulfuretin as a new anti-obesity intervention for the prevention of obesity and its associated metabolic diseases.

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Reciprocal Regulation of Adipocyte and Osteoblast Differentiation of Mesenchymal Stem Cells byEupatorium japonicumPrevents Bone Loss and Adiposity Increase in Osteoporotic Rats

Cited by 11 publications

References 34 publications

Influence of olive oil and its components on mesenchymal stem cell biology

Influence of olive oil and its components on mesenchymal stem cell biology

Hexane Extract of Chloranthus japonicus Increases Adipocyte Differentiation by Acting on Wnt/β-Catenin Signaling Pathway

Sulfuretin Prevents Obesity and Metabolic Diseases in Diet Induced Obese Mice

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