Effects of nandrolone propionate on experimental tumor growth and cancer cachexia

Lyden, E; Cvetkovska, E; Westin, Thomas; Oldfors, Anders; Soussi, B.; Gustafsson, Bertil; Edström, Staffan

doi:10.1016/0026-0495(95)90050-0

Cited by 15 publications

(5 citation statements)

References 34 publications

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“…Furthermore, our data demonstrate that testosterone increased the relative liver weight. Lydén et al [20] and Pignata et al [21] demonstrated the effectiveness of the steroid nandrolone decanoate in increase liver mass even in cases of cancer. Besides, Vieira et al [14] had similar effects to those described in our study.…”

Section: Discussionmentioning

confidence: 99%

Effects of testosterone administration on liver structure and function in aging rats

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Effects of testosterone administration on liver structure and function in aging rats

et al. 2017

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“…However, only a few controlled trials have been performed to ascertain whether this represents an influence of hormones on nutritional intake or vice versa. Preclinical trials with nandrolone decanoate in rats did not support the former hypothesis (66). In 1988, Todd (65) reported that malnutrition and the resulting weight loss in patients with pancreatic cancer are responsible for hypogonadism, rather than hypogonadism being the culprit.…”

Section: Therapies Currently In Use For Treatment Of Cachexiamentioning

confidence: 94%

Anabolic-Androgenic Steroid Therapy in the Treatment of Chronic Diseases

Basaria

Wahlstrom

Dobs

2001

The Journal of Clinical Endocrinology &Amp; Metabolism

230

175

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The purpose of this study was to review the preclinical and clinical literature relevant to the efficacy and safety of anabolic androgen steroid therapy for palliative treatment of severe weight loss associated with chronic diseases. Data sources were published literature identified from the Medline database from January 1966 to December 2000, bibliographic references, and textbooks. Reports from preclinical and clinical trials were selected. Study designs and results were extracted from trial reports. Statistical evaluation or meta-analysis of combined results was not attempted.Androgenic anabolic steroids (AAS) are widely prescribed for the treatment of male hypogonadism; however, they may play a significant role in the treatment of other conditions as well, such as cachexia associated with human immunodeficiency virus, cancer, burns, renal and hepatic failure, and anemia associated with leukemia or kidney failure. A review of the anabolic effects of androgens and their efficacy in the treatment of these conditions is provided. In addition, the numerous and sometimes serious side effects that have been known to occur with androgen use are reviewed.Although the threat of various side effects is present, AAS therapy appears to have a favorable anabolic effect on patients with chronic diseases and muscle catabolism. We recommend that AAS can be used for the treatment of patients with acquired immunodeficiency syndrome wasting and in severely catabolic patients with severe burns. Preliminary data in renal failure-associated wasting are also positive. Advantages and disadvantages should be weighed carefully when comparing AAS therapy to other weight-gaining measures. Although a conservative approach to the use of AAS in patients with chronic diseases is still recommended, the utility of AAS therapy in the attenuation of severe weight loss associated with disease states such as cancer, postoperative recovery, and wasting due to pulmonary and hepatic disease should be more thoroughly investigated. (J Clin Endocrinol Metab 86: 5108 -5117, 2001)

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“…Calculations of labeling index, DNA synthesis time (T s ), potential doubling time (T pot ), and DNA distribution were performed as described previously 10,11 using the Lysus II program (NJ), assuming a uniform distribution and a linear progression of cells throughout the cell cycle. At least 10,000 events were collected in a list mode for these calculations.…”

Section: Methodsmentioning

confidence: 99%

Overexpression of p53‐Related Proteins Predicts Rapid Growth Rate of Head and Neck Cancer

et al. 2001

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Effects of nandrolone propionate on experimental tumor growth and cancer cachexia

Cited by 15 publications

References 34 publications

Effects of testosterone administration on liver structure and function in aging rats

Effects of testosterone administration on liver structure and function in aging rats

Anabolic-Androgenic Steroid Therapy in the Treatment of Chronic Diseases

Overexpression of p53‐Related Proteins Predicts Rapid Growth Rate of Head and Neck Cancer

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