Effects of testosterone administration on liver structure and function in aging rats

Abstract

Our study showed many implications for the knowledge about the effects of aging with or without testosterone administration on old animals' liver.

Testosterone Administration Alters Hepatic Blood Flow Across Age: Systematic Review of Animal Experimental Studies

“…The systematic review data was organized in ►Tables 1 and 2. 15,16 For the meta-analysis, RevMan 5.2 software (The Nordic Cochrane Centre, Copenhagen, Denmark) was used to calculate heterogeneity by the i-squared (I 2 ) and chisquared (χ 2 ) values. We have used the I 2 to assess the heterogeneity/homogeneity between the studies, using fixed effect models.…”

“…After the inclusion and exclusion criteria were applied, two papers were included in the systematic review and meta-analysis. 15,16 However, the small number of included papers should be considered a limitation.…”

“…Tanasov et al 16 used testosterone propionate via intramuscular administration (3 mg/kg) for 3 months. However, Nucci et al 15 used testosterone propionate via intraperitoneal administration (10 mg/kg) for 4 months.…”

“…negative effects on the structure and function of the liver across age. [15][16][17] The liver has its functions changed with advancing age, resulting in impaired regeneration and in a decrease in drug metabolism. 18,19 Thus, testosterone administration can induce pathological conditions across age.…”

“…18,19 Thus, testosterone administration can induce pathological conditions across age. 15,16 Currently, the clinical literature uses systematic reviews and meta-analyses to identify possible methodological differences in the studies, in the quality of the surveyed studies on a given topic, and in the most suitable intervention for a specific treatment. 8 Therefore, the present study aimed to carry out a systematic review of the effects of testosterone administration on the hepatic structure of adult and aged animals.…”