Effects of Naloxone Infusion in Patients with Septic Shock and Renal Failure: A Limited Experience

Abstract

Septic shock is frequently associated with acute renal failure. Management of these patients becomes complicated if either the renal or systemic hemodynamic derangement cannot be corrected. Although previously large doses of furosemide and naloxone infusion have been used separately in managing these patients, the combination of both agents has not been employed. We therefore report our limited experience with this combined treatment in 5 patients with septic shock, of which 4 had acute renal failure.

Naloxone and epinephrine are equally effective for cardiopulmonary resuscitation in a rat asphyxia model

“…Naloxone is used most often to reverse opioid‐induced respiratory depression (6, 7). It has also been used in many varieties of shock (8–11). Except for death due to opioid overdose, little knowledge is available on the efficacy of naloxone during variants of cardiac arrest and CPR.…”