2018
DOI: 10.18632/aging.101561
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: N-acetyl-L-cysteine (NAC) is a derivative of the sulphur-containing amino acid L-cysteine with potential anti-aging properties. We studied 3 Drosophila species with contrast longevity differences (D. virilis is longest-lived, D. kikkawai is shortest-lived and D. melanogaster has moderate lifespan) to test the effects of NAC at 8 different concentrations (from 10 nM to 100 mM) on the lifespan, stress-resistance and locomotor activity. Except the adverse effects of highest (10 mM and 100 mM) concentrations NAC d… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
9
0

Year Published

2019
2019
2020
2020

Publication Types

Select...
3
1

Relationship

1
3

Authors

Journals

citations
Cited by 24 publications
(10 citation statements)
references
References 65 publications
(93 reference statements)
1
9
0
Order By: Relevance
“…Due to its capacity to break down biofilms and improve antibiotic permeability, it is promising as an adjuvant antimicrobial drug [75]. Several pre-clinical studies have also demonstrated that NAC supplementation leads to life extension and diminished effects of aging, in invertebrates [76,77,78,79] as well as mammals [80] and in human breast epithelial stem cells [81]. Such findings have yet to be replicated in humans.…”
Section: Medical Use Of Nacmentioning
confidence: 99%
“…As a potentially interesting supplement in relation with the GM, N-acetyl-L-cysteine, a precursor of the biologic antioxidant glutathione, was shown to inhibit muscle fatigue in humans 101 and to display male-specific effects on Drosophila lifespan, stress-resistance and locomotor activity. 102 Interestingly, the benefits of N-acetyl-L-cysteine against dysbiosis and glucose metabolic disorders were recently shown in high-fat diet-fed mice. 103 In addition, apelin was identified as a diagnostic tool of early sarcopenia and a potential target to prevent muscle weakness in a study using mouse models and participants of Multidomain Alzheimer Prevention Trial (MAPT study) and Life-P. 104 Production of the peptide is induced by muscle contraction in an age-dependent manner and increases muscle strength.…”
Section: Perspectives: Balancing the Gut Microbiota To Prevent Or Trementioning
confidence: 99%
“…As a potentially interesting supplement in relation with the GM, N-acetyl-L-cysteine, a precursor of the biologic antioxidant glutathione, was shown to inhibit muscle fatigue in humans 101 and to display male-specific effects on Drosophila lifespan, stress-resistance and locomotor activity. 102 Interestingly, the benefits of N-acetyl-L-cysteine against dysbiosis and glucose metabolic disorders were recently shown in high-fat diet-fed mice. 103 …”
Section: Perspectives: Balancing the Gut Microbiota To Prevent Or Trementioning
confidence: 99%
“…As the JAK/STAT pathway is evolutionarily conserved it may be possible to discover compounds that fit the criteria of geroprotector [48]. In our prior work we explored the effects of a variety of interventions on the Drosophila lifespan [4953]. The new pathway analysis algorithms enable us to identify the pharmacological interventions for modulation of the levels of expression of individual genes and networks.…”
Section: Discussionmentioning
confidence: 99%
“…Drosophila melanogaster was maintained on a fresh medium prepared with the Nutrifly Bloomington formulation (Genesee Scientific, San Diego, CA, USA), supplemented with 64 mM propionic acid and dried yeast. N-acetyl-L-cysteine (NAC) supplemented medium were prepared at the final concentration of 1 mM (A9165, Sigma (Shaposhnikov et al 2018)).…”
Section: Drosophila Stocks and Rearingmentioning
confidence: 99%