Effects of myocardial revascularisation in patients with effort angina and those with effort and nocturnal angina.

Quyyumi, Arshed A.; Wright, Christine; Mockus, L; Yacoub, Mena; Fox, Kim

doi:10.1136/hrt.54.6.557

Cited by 22 publications

(4 citation statements)

References 17 publications

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“…Recently, evidence has accumulated that during the post-CABG period, a remarkably high proportion of patients have asymptomatic myocardial ischemia. 14,15 Ribeiro and colleagues 14 advised that even when graft patency is established, it is not necessarily indicative of physiologic relief of transient myocardial ischemia. Their study using regional myocardial perfusion positron emission tomography and ambulatory electrocardiography, showed that relief of angina symptoms after CABG could be attributed to 3 different mechanisms: relief of transient ischemia; perioperative myocardial infarction; and conversion of angina pectoris to silent myocardial ischemia.…”

Section: Discussionmentioning

confidence: 99%

Myocardial Ischemia after Coronary Bypass: Comparison of Trimetazidine and Diltiazem

Kuralay

Demirkılıç²,

Özal³

et al. 1999

Asian Cardiovasc Thorac Ann

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The aim of this prospective randomized study was to evaluate the effect of trimetazidine and diltiazem on persistent myocardial ischemia, mostly silent myocardial ischemia, after coronary artery bypass graft surgery. Sixty patients were divided into three groups of 20 each and followed up for 12 months. Patients in all 3 groups received acetylsalicylic acid 100 mg per day, those in group 1 also had trimetazidine 60 mg per day, and those in group 2 had diltiazem 90 mg per day. Each patient had coronary angiography during the first 3 weeks after surgery, 24-hour ambulatory monitoring every month, and cardiac scintigraphy at 3 weeks, 6 months, and 12 months. Ischemic episodes had resolved at 27 weeks in group 1, at 35 weeks in group 2 and at 51 weeks in group 3 (p < 0.05). Perfusion defects had resolved in the trimetazidine group at 6 months. At 12 months, perfusion defects had resolved in the diltiazem group but not in the group receiving only acetylsalicylic acid (p < 0.05). At these doses, trimetazidine and diltiazem were effective in decreasing silent myocardial ischemia following coronary artery bypass grafting. Trimetazidine appeared to be superior to diltiazem at 6 months on 24-hour ambulatory electrocardiogram monitoring and myocardial scintigraphy.

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Section: Discussionmentioning

confidence: 99%

Myocardial Ischemia after Coronary Bypass: Comparison of Trimetazidine and Diltiazem

Kuralay

Demirkılıç²,

Özal³

et al. 1999

Asian Cardiovasc Thorac Ann

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“…Não houve relação no presente estudo, entre episódi-os sintomáticos e assintomáticos, quanto ao comportamento das FCmin, FCmed, FCmax, no início e na máxima magnitude do desnível do segmento ST, concordando com outros estudos 30,33 , onde não foi possível relacionar a presença ou não de sintomas ao comportamento das variáveis obtidas por meio da ECGA.…”

Section: Discussionunclassified

“…A cirurgia proporcionou, conforme esperado 32,33 , aumento significativo da tolerância ao exercício, da FC e do duplo produto ao esforço máximo, às custas da suspensão da isquemia e da angina 33,35 . Propiciou, também, redução expressiva do número de EIA.…”

Section: Discussionunclassified

Efeito da cirurgia de revascularização miocárdica sobre os episódios isquêmicos assintomáticos

Pierri¹,

Wajngarten²,

Serro-Azul³

et al. 1998

Arq. Bras. Cardiol.

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Pierri e col Efeito de revascularização miocárdica sobre isquemia assintomática 265Instituto do Coração do Hospital das Clínicas -FMUSP Correspondência: Humberto Pierri -Rua Rocha, 167 -conj 33 -01330-000 -São Paulo, SP Recebido para publicação em 10/10/97 Aceito em 18/2/98 Os episódios isquêmicos assintomáticos são mais freqüentes que os sintomáticos e parecem implicar em pior prognóstico, particularmente, em determinadas situações que coincidem com a indicação para tratamento cirúrgico 1 . Contudo, o tratamento cirúrgico para essa modalidade de isquemia tem apresentado resultados variáveis, provavelmente, relacionados a problemas metodológicos. De fato, nos diferentes estudos foram incluídos pacientes com diabetes mellitus, com hipertensão arterial (HA), além de outras doenças que poderiam estar interferindo com a microcirculação coronária, ou sob medicação durante a investigação 2 . Assim, foi objetivo deste trabalho avaliar os efeitos da cirurgia de revascularização miocárdica (CRM) em pacientes, com indicação formal deste procedimento e que apresentavam episódios isquêmicos assintomáticos (EIA). Effect of Coronary Artery Bypass Graft Surgery on Ischemic Asymptomatic Episodes

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“…These patients have been previously reported as part of studies assessing the effects of CABG on such transient ST segment changes detected by ambulatory monitoring. 12 artery disease. During surgery the mean number of bypass grafts (including the internal mammary artery graft) was 3-3 (range 1-5).…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of transient ST segment changes after coronary artery bypass surgery: a long-term (4-10 year) follow up study.

Patel

Mulcahy²,

Curzen³

et al. 1993

Heart

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Effects of myocardial revascularisation in patients with effort angina and those with effort and nocturnal angina.

Abstract: SUMMA;RY The effects of coronary artery bypass graft operation were studied in 32

Cited by 22 publications

References 17 publications

Myocardial Ischemia after Coronary Bypass: Comparison of Trimetazidine and Diltiazem

Myocardial Ischemia after Coronary Bypass: Comparison of Trimetazidine and Diltiazem

Efeito da cirurgia de revascularização miocárdica sobre os episódios isquêmicos assintomáticos

Prognostic significance of transient ST segment changes after coronary artery bypass surgery: a long-term (4-10 year) follow up study.

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