Effects of muscle perfusion pressure on fatigue  and systemic arterial pressure in human subjects

Wright, Julie R.; McCloskey, D.I.; Fitzpatrick, Richard C.

doi:10.1152/jappl.1999.86.3.845

Cited by 41 publications

(48 citation statements)

References 18 publications

(28 reference statements)

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“…Malnutrition causes decrease of contraction strength, relaxation rate, and increase of muscle fatigue of the adductor muscle of the thumb. Several functional and morphological alterations 13 have been demonstrated in healthy adults related to temperature, neuromuscular blocking 16 , intensity of generated force, age 17 , gender 18 , race, perfusion pressure 19 , and nutritional state. However, in daily clinical practice, the routine utilization of electromyography or electric stimulation of the ulnar nerve is difficult, not only due to its high cost, but also because of the need for experience with the procedure.…”

Section: Discussionmentioning

confidence: 99%

Adductor policis muscle: a new anthropometric parameter

et al. 2004

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PURPOSE:To measure the thickness of adductor pollicis muscle in healthy adults. This measurement will be used as a nutritional anthropometric parameter in further studies. SUBJECTS AND METHOD:Four hundred and twenty-one healthy adults were studied, 209 men and 212 women, with ages ranging from 18 to 87 years, living in Rio de Janeiro.The adductor pollicis muscle was also studied in the human anatomy lab as well as in normal healthy volunteers using CAT scans and nuclear magnetic resonance imaging to ensure that only the adductor pollicis was included in measurement of muscle thickness with a Lange caliper.To standardize the measurement, the methodology was detailed, with subjects sitting with the dominant hand dangling over the homolateral thigh and the elbow bent at approximately a 90° angle. The Lange caliper was applied at a pressure of 10 g/mm 2 , pinching the adductor pollicis muscle at the vertex of an imaginary angle between the thumb and the index finger. The average of 3 consecutive measurements was considered to be the muscle thickness.RESULTS: This study provides the first estimates of adductor pollicis thickness in normal healthy subjects as an anthropometric parameter. The normal values in the dominant hand for men were 12.5 ± 2.8 mm (mean ± SD), median 12 mm, and for women were 10.5 ± 2.3 mm, median 10 mm.

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Section: Discussionmentioning

confidence: 99%

Adductor policis muscle: a new anthropometric parameter

et al. 2004

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“…Conversely, minimal flow recovery was observed when local forearm perfusion pressure was acutely reduced via positional changes (i.e., forearm above heart level) (498). A lack of flow restoration with positional perfusion lowering is further supported by the idea that muscle force production is reduced and fatigue can be increased by reductions in perfusion pressure (517,518). Taken together, the magnitude of flow restoration or compensation and mechanisms involved appear to be dependent on the experimental approach used to induce hypoperfusion in contracting skeletal muscle.…”

Section: O Blood-borne Vasodilator Substancesmentioning

confidence: 97%

Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs

Joyner

Casey

2015

Physiological Reviews

552

513

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LJoyner MJ, Casey DP. Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs. Physiol Rev 95: 549 -601, 2015; doi:10.1152/physrev.00035.2013.-This review focuses on how blood flow to contracting skeletal muscles is regulated during exercise in humans. The idea is that blood flow to the contracting muscles links oxygen in the atmosphere with the contracting muscles where it is consumed. In this context, we take a top down approach and review the basics of oxygen consumption at rest and during exercise in humans, how these values change with training, and the systemic hemodynamic adaptations that support them. We highlight the very high muscle blood flow responses to exercise discovered in the 1980s. We also discuss the vasodilating factors in the contracting muscles responsible for these very high flows. Finally, the competition between demand for blood flow by contracting muscles and maximum systemic cardiac output is discussed as a potential challenge to blood pressure regulation during heavy large muscle mass or whole body exercise in humans. At this time, no one dominant dilator mechanism accounts for exercise hyperemia. Additionally, complex interactions between the sympathetic nervous system and the microcirculation facilitate high levels of systemic oxygen extraction and permit just enough sympathetic control of blood flow to contracting muscles to regulate blood pressure during large muscle mass exercise in humans.

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“…However, there is evidence that this does not necessarily occur. For instance, simply raising the arm above the head accelerates the rate of fatigue of the adductor pollicis (490). This arises because the hydrostatic fall in arterial pressure in the hand is not matched by the fall in venous pressure presumably because the veins collapse.…”

Section: Blood Flow and Intracellular Pomentioning

confidence: 99%

Skeletal Muscle Fatigue: Cellular Mechanisms

Allen¹,

Lamb²,

Westerblad³

2008

Physiological Reviews

1,855

1,876

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Repeated, intense use of muscles leads to a decline in performance known as muscle fatigue. Many muscle properties change during fatigue including the action potential, extracellular and intracellular ions, and many intracellular metabolites. A range of mechanisms have been identified that contribute to the decline of performance. The traditional explanation, accumulation of intracellular lactate and hydrogen ions causing impaired function of the contractile proteins, is probably of limited importance in mammals. Alternative explanations that will be considered are the effects of ionic changes on the action potential, failure of SR Ca2+ release by various mechanisms, and the effects of reactive oxygen species. Many different activities lead to fatigue, and an important challenge is to identify the various mechanisms that contribute under different circumstances. Most of the mechanistic studies of fatigue are on isolated animal tissues, and another major challenge is to use the knowledge generated in these studies to identify the mechanisms of fatigue in intact animals and particularly in human diseases.

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Effects of muscle perfusion pressure on fatigue and systemic arterial pressure in human subjects

Cited by 41 publications

References 18 publications

Adductor policis muscle: a new anthropometric parameter

Adductor policis muscle: a new anthropometric parameter

Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs

Skeletal Muscle Fatigue: Cellular Mechanisms

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