Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat

Ahmed, Ijaz; Adeghate, Ernest; Sharma, Ashutosh; Pallot, D. J.; Singh, Jaipaul

doi:10.1016/s0168-8227(98)00022-9

Cited by 186 publications

(133 citation statements)

References 13 publications

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“…These results were reported through histological observations, together with a notable improvement in blood sugar levels. Another medicinal plant reported to have beneficial effects on islet morphology is the bitter melon Momordica charantia (Ahmed et al, 1998). A recent histological analysis of alloxan-induced diabetic rats treated with berberine, the main active constituent of Rhizoma coptidis, showed that it was able to alleviate the progression of diabetes (Tang et al, 2006).…”

Section: Histopathological Resultsmentioning

confidence: 99%

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Vinagre

Rönnau

Pereira

et al. 2010

Braz. J. Pharm. Sci.

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The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocininduced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and kidneys. No differences were found between the control rats treated with the decoction and the control rats maintained on water only. In conclusion, these results suggest that C. xanthocarpa leaf decoction (20g/L) might be useful for diabetes mellitus management, but further pharmacological and toxicological studies are needed. O objetivo deste trabalho foi identificar os efeitos do tratamento com o decocto das folhas de Campomanesia xanthocarpa Berg. (20 g/L), durante 3 semanas, sobre parâmetros fisiológicos, bioquímicos e histológicos de ratos normais e diabéticos induzidos por estreptozotocina. O diabete melito foi induzido uma semana antes de iniciar o tratamento experimental, pela administração IP de estreptozotocina (STZ, 70 mg/ kg em tampão citrato, pH 4.5). Os ratos tratados com STZ apresentaram sintomas típicos de diabete: polifagia, polidipsia, hiperglicemia, hipertrigliceridemia e alterações histopatológicas no pâncreas, fígado e rim. O tratamento dos ratos diabéticos com o decocto diminuiu os níveis de glicose sanguínea, inibiu a degradação do glicogênio hepático e preveniu possíveis alterações histopatológicas no pâncreas e no rim. Nos ratos controles tratados com o decocto não foram verificadas diferenças significativas em relação aos controles tratados com água. Em conclusão, os resultados sugerem que o tratamento com o decocto das folhas de C. xanthocarpa leaf decoction (20 g/L) possa ser útil para o manejo do diabete melito, porém estudos farmacológicos e toxicológicos ainda são necessários.Unitermos: Campomanesia xanthocarpa/farmacognosia. Diabete Melito/estudo experimental. Planta hipoglicemiante. Carboidratos/metabolismo. Lipídeos/metabolismo.

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Section: Histopathological Resultsmentioning

confidence: 99%

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Vinagre

Rönnau

Pereira

et al. 2010

Braz. J. Pharm. Sci.

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“…At maturity, the fruit splits into three irregular valves that curl backwards and release numerous reddish-brown seeds. Biological actions of various extracts of the plants or its constituents include antidiabetic (Ahmed et al, 1998;Mastuda et al, 1999;Raza et al, 2000), anti ulcerogenic (Gürbüz et al, 2000), antimutagenic (Guevara et al, 1990), antioxidant (Scartezzini & Speroni, 2000), anti-tumour (Lee-Huang et al, 1995a), immunomodulatory (Spreafico et al, 1983). Two proteins known as α -and β -monorcharin which are present in the seeds, fruits and leaves have shown to inhibit the human immune deficiency virus (HIV) in vitro (Zhang, 1992;LeeHuang et al, 1995b).…”

Section: Introductionmentioning

confidence: 99%

Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice

Patil

2011

Int. J. Morphol.

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“…The most noteworthy health benefit of bitter gourd are the hypoglycemic potential demonstrated in normal [36] and diabetic [2,7,27,31] rats as well as in human subjects with type II diabetes mellitus [21] and its hypolipidemic effect [3,15,26,29]. The mechanism for the hypoglycemic effect of bitter gourd is still unclear, although it has been shown to inhibit glucose absorption [23], promote hepatic glucose utilization [31], possess an insulin-like polypeptide [18], and even to increase the insulin-positive cell number in the pancreas [1].…”

Section: Introductionmentioning

confidence: 99%

Fractionation and identification of 9c, 11t, 13t-conjugated linolenic acid as an activator of PPARα in bitter gourd (Momordica charantia L.)

et al. 2006

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SummaryBitter gourd (Momordica charantia L.) is a common vegetable in Asia that has been used in traditional medicine for the treatment of Diabetes. PPARs are ligand-dependent transcription factors that belong to the steroid hormone nuclear receptor family and control lipid and glucose homeostasis in the body. We previously reported that the ethyl acetate (EA) extract of bitter gourd activated peroxisome proliferator receptors (PPARs) a and c. To identify the active compound that activated PPARa, wild bitter gourd EA extract was partitioned between n-hexane and 90% methanol/10% H 2 O, and the n-hexane soluble fraction was further separated by silica gel column chromatography and finally by preparative HPLC. A transactivation assay employing a clone of CHOK1 cells stably transfected with a (UAS) 4 -tk-alkaline phosphatase reporter and a chimeric receptor of GAL4-rPPARa LBD was used to track the active component. Based on Mass, NMR, and IR spectroscopy, 9cis, 11trans, 13trans-conjugated linolenic acid (9c, 11t, 13t-CLN) was identified as a PPARa activator in wild bitter gourd. The isolated 9c, 11t, 13t-CLN rich fraction also significantly induced acyl CoA oxidase (ACO) activity in a peroxisome proliferator-responsive murine hepatoma cell line, H4IIEC3, implying that 9c, 11t, 13t-CLN was able to act on a natural PPARa signaling pathway as well. The content of 9c, 11t, 13t-CLN was estimated to be about 7.1 g/kg of our dried wild bitter gourd sample. The concentration of 9c, 11t, 13t-CLN and activation activity in the hydrolyzed EA extract of the seeds was higher than that of the flesh. The potential health benefits of 9c, 11t, 13t-CLN through the PPARa regulated mechanism are worthy to be further characterized in in vivo studies.

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Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat

Cited by 186 publications

References 13 publications

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice

Fractionation and identification of 9c, 11t, 13t-conjugated linolenic acid as an activator of PPARα in bitter gourd (Momordica charantia L.)

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