Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Abstract

The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocininduced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and kidneys. No differences were found between the control rats treated with the decoction and the control rats maintained on water only. In conclusion, these results suggest that C. xanthocarpa leaf decoction (20g/L) might be useful for diabetes mellitus management, but further pharmacological and toxicological studies are needed. O objetivo deste trabalho foi identificar os efeitos do tratamento com o decocto das folhas de Campomanesia xanthocarpa Berg. (20 g/L), durante 3 semanas, sobre parâmetros fisiológicos, bioquímicos e histológicos de ratos normais e diabéticos induzidos por estreptozotocina. O diabete melito foi induzido uma semana antes de iniciar o tratamento experimental, pela administração IP de estreptozotocina (STZ, 70 mg/ kg em tampão citrato, pH 4.5). Os ratos tratados com STZ apresentaram sintomas típicos de diabete: polifagia, polidipsia, hiperglicemia, hipertrigliceridemia e alterações histopatológicas no pâncreas, fígado e rim. O tratamento dos ratos diabéticos com o decocto diminuiu os níveis de glicose sanguínea, inibiu a degradação do glicogênio hepático e preveniu possíveis alterações histopatológicas no pâncreas e no rim. Nos ratos controles tratados com o decocto não foram verificadas diferenças significativas em relação aos controles tratados com água. Em conclusão, os resultados sugerem que o tratamento com o decocto das folhas de C. xanthocarpa leaf decoction (20 g/L) possa ser útil para o manejo do diabete melito, porém estudos farmacológicos e toxicológicos ainda são necessários.Unitermos: Campomanesia xanthocarpa/farmacognosia. Diabete Melito/estudo experimental. Planta hipoglicemiante. Carboidratos/metabolismo. Lipídeos/metabolismo.

Effect of vitamin D3on behavioural and biochemical parameters in diabetes type 1-induced rats

“…Therefore, we used a well-established model to induce type 1 diabetes with STZ. Similar to previous reports 8,24,25 in this study, diabetic rats showed polyphagia, polydipsia and weight loss ( Table 1). Statistical analysis showed a significant effect of diabetes on all aforementioned parameters (P < 0.0001) when compared with the control group.…”

Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

“…In addition to its effect on cholesterol levels, this plant showed potential anti-inflammatory because reduced oxidative stress in hypercholesterolemic patients improving the levels of NOx [11]. Antiplatelet, antithrombotic, and fibrinolytic activities [12] and antioxidant [13], antidiabetic [14], antiulcer activities [15] of C. xanthocarpa leaves were scientifically demonstrated in the literature. The studies with essential oil showed anti-fungic effects [16].…”

Extraction of Campomanesia xanthocarpa fruit using supercritical CO2 and bioactivity assessments

“…Besides the fresh fruits consumption and utilization in the food industry, extracts of C. xanthocarpa fruits and leaves have been used in folk medicine on several diseases. There are some studies presented in the literature that are confirming the beneficial effects against diseases, preventing gastric ulceration, acting in cholesterol levels decrease and overweight control and in the diabetes mellitus management [3][4][5][6]. Moreover, other studies demonstrated biological activity of fruit and leave extracts obtained by hydrodistillation and maceration as antioxidant and antibacterial agent [7][8][9].…”

Campomanesia lineatifolia Ruiz & Pav. as a gastroprotective agent

“…Ktafke et al (2010) have demonstrated that Campomanesia xanthocarpa reduced total cholesterol and LDL levels in the blood of hypercholesterolemic patients. The same species brought about a significant decrease in blood glucose levels and hepatic glycogen loss and prevented potential histopathological alterations in the pancreas and kidneys in streptozotocin diabetic rats (Vinagre et al, 2010). Moreover, the oral administration of the Campomanesia xanthocarpa extract at 400 mg/kg attenuated gastric mucosal lesions induced by ethanol in rats (Markman et al, 2004).…”

Investigation of Campomanesia Components: A Fruit of Brazilian Cerrado

“…In the traditional medicine in Brazil, the roots and leaves of C. xanthocarpa Berg. are used for antidiabetic effects [18].…”