2010
DOI: 10.1590/s1984-82502010000200002
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Abstract: The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocininduced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopa… Show more

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Cited by 35 publications
(26 citation statements)
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References 28 publications
(46 reference statements)
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“…Therefore, we used a well-established model to induce type 1 diabetes with STZ. Similar to previous reports 8,24,25 in this study, diabetic rats showed polyphagia, polydipsia and weight loss ( Table 1). Statistical analysis showed a significant effect of diabetes on all aforementioned parameters (P < 0.0001) when compared with the control group.…”
Section: Discussionsupporting
confidence: 92%
“…In addition to its effect on cholesterol levels, this plant showed potential anti-inflammatory because reduced oxidative stress in hypercholesterolemic patients improving the levels of NOx [11]. Antiplatelet, antithrombotic, and fibrinolytic activities [12] and antioxidant [13], antidiabetic [14], antiulcer activities [15] of C. xanthocarpa leaves were scientifically demonstrated in the literature. The studies with essential oil showed anti-fungic effects [16].…”
Section: Introductionmentioning
confidence: 97%
“…Besides the fresh fruits consumption and utilization in the food industry, extracts of C. xanthocarpa fruits and leaves have been used in folk medicine on several diseases. There are some studies presented in the literature that are confirming the beneficial effects against diseases, preventing gastric ulceration, acting in cholesterol levels decrease and overweight control and in the diabetes mellitus management [3][4][5][6]. Moreover, other studies demonstrated biological activity of fruit and leave extracts obtained by hydrodistillation and maceration as antioxidant and antibacterial agent [7][8][9].…”
Section: Introductionmentioning
confidence: 79%
“…Ktafke et al (2010) have demonstrated that Campomanesia xanthocarpa reduced total cholesterol and LDL levels in the blood of hypercholesterolemic patients. The same species brought about a significant decrease in blood glucose levels and hepatic glycogen loss and prevented potential histopathological alterations in the pancreas and kidneys in streptozotocin diabetic rats (Vinagre et al, 2010). Moreover, the oral administration of the Campomanesia xanthocarpa extract at 400 mg/kg attenuated gastric mucosal lesions induced by ethanol in rats (Markman et al, 2004).…”
Section: Introductionmentioning
confidence: 92%
“…In the traditional medicine in Brazil, the roots and leaves of C. xanthocarpa Berg. are used for antidiabetic effects [18].…”
Section: Introductionmentioning
confidence: 99%