Effects of molecular structure on antitumor activities of (1→3)-β-d-glucans from different Lentinus Edodes

Physiological activities of a β-glucan produced by Panebacillus polymyxa

“…However, increase in the level of inhibition of Sarcoma 180 cell proliferation was low in relation to the rate of b-glucan JB115 dose increase. This result is consistent with the reported antitumor effects of b-(1?3) glucans isolated from P. cocos mycelia (Huang et al 2006) and Lenitinus Edodes (Surenjav et al 2006) against Sarcoma 180. The antitumor activities of b-glucans are determined by their molecular weight and solubility in water (Tokunaka et al 2002), which may explain why the antitumor activity of b-glucan JB115 did not increase to a significant extent at higher concentrations.…”

Carboxylate groups play a major role in antitumor activity of Ganoderma applanatum polysaccharide

“…Therefore, FGAP showed a much better antitumor activity against Sarcoma 180 in vivo than SGAP, which was closely related to the structure difference including molecular weight, monosaccharide component and functional groups between the two polysaccharides (Peng et al, 2005;Surenjav et al, 2006;Zhang et al, 1999Zhang et al, , 2001. Especially, carboxylate groups as a possibly important factor to lead FGAP to a distinct antitumor activity should attract more attention, because certain literatures had indicated that ionic groups play major roles in antitumor activities of polysaccharides by expanding their conformations and interacting with proteins (Peng et al, 2005;Surenjav et al, 2006;Tao et al, 2006;Wang et al, 2009;Zhang et al, 2001Zhang et al, , 2004. In order to further survey the effect of carboxylate groups on the antitumor activities of these polysaccharides, carboxylate groups were chemically introduced into SGAP by carboxymethylation.…”

“…However, the polysaccharides isolated from submerged fermentation and from wild fruit bodies might present different structures and antitumor activities because of their different growing time and conditions. It has been demonstrated that bioactivities of polysaccharides are closely related to their structures including monosaccharide components, molecular weight, degree of substitution, degree of branching, chain conformation in solution and the main chain and branches (Peng et al, 2005;Surenjav, Zhang, Xu, Zhang, & Zeng, 2006;Zhang, Cheung, & Zhang, 2001;Zhang, Zhang, & Cheng, 1999). Recently, the introductions of suitable ionic groups into polysaccharides, such as carboxymethylation and chemical sulfation, have attracted more attention because they could not only enhance the water solubility but also change the chain conformation, resulting in the improvement of their antitumor activities (Tao, Zhang, & Cheung, 2006;Wang, Zhang, Yu, & Cheung, 2009;Zhang, Cheung, Ooi, & Zhang, 2004).…”

Chemical characterization and antitumor activity of an exopolysaccharide from Pholiota Squarrosa Quel. AS 5.245

“…The ratio of body weight gain of PEPS-1 group mice at 50 mg/kg was 24.35%, which was significantly (p<0.05) higher than that of the 5-Fu treated group. Thus, PEPS-1 did not have the same toxicity as 5-Fu, which killed normal cells along with cancer cells (19).…”