Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells

The miR-34 family in cancer and apoptosis

“…Loss of miR-34 through genetic or epigenetic mechanisms interrupts this feedback resulting in lower p53 activity and thereby provides a selective advantage for cancer cells. Fujita et al 42 also reported regulation of SIRT1 by miR-34a, although they exclusively observed the effects of miR-34a on the expression of SIRT1 mRNA and not on the translation. Another feedback loop between p53 and miR-34a may involve the downregulation of the p53-inhibitor HDMX by miR-34a.…”

MicroRNA-125b Confers the Resistance of Breast Cancer Cells to Paclitaxel through Suppression of Pro-apoptotic Bcl-2 Antagonist Killer 1 (Bak1) Expression

“…The "knockdown" and inhibition of miR-221 or miR-222 expression has been shown to sensitize MDA-MB-468 cells to tamoxifen-induced cell growth arrest and apoptosis (17). Ectopic miR-34a expression resulted in cell cycle arrest and growth inhibition and attenuated chemoresistance to the anticancer drug, camptothecin, by inducing apoptosis (18). To date, however, the interaction between miRNAs and Taxol resistance in cancer cells has not been explored.…”

Exosomal microRNAs in liquid biopsies: future biomarkers for prostate cancer

“…Regarding other important factors, it has been observed that the miRNAs content of exosomes plays a role in docetaxel resistance. mir-34a that was significantly decreased in prostate cancer versus normal tissues as well as in urine, regulates BCL-2 and may in part, regulate the response to docetaxel [76,77].…”