Effects of mindfulness meditation training on anticipatory alpha modulation in primary somatosensory cortex

Kerr, Catherine E.; Jones, Stephanie R.; Wan, Qian; Pritchett, Dominique L.; Wasserman, Rachel H.; Wexler, Anna; Villanueva, Joel J.; Shaw, Jessica; Lazar, Sara W.; Kaptchuk, Ted J.; Littenberg, Ronnie; Hämäläinen, Matti S.; Moore, Christopher I.

doi:10.1016/j.brainresbull.2011.03.026

Cited by 107 publications

(104 citation statements)

References 49 publications

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“…The strong correlation between the magnitude of the a-band oscillation at the onset of motion and the duration of spontaneous movement epoch (Fig. 3C) is consistent with a connection to motor planning networks in parietal cortex (Pfurtscheller and Aranibar 1979;Capotosto et al 2009;Kerr et al 2011).…”

supporting

confidence: 51%

α-Band oscillations in intracellular membrane potentials of dentate gyrus neurons in awake rodents

Anderson

Strowbridge

2014

Learn. Mem.

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The hippocampus and dentate gyrus play critical roles in processing declarative memories and spatial information. Dentate granule cells, the first relay in the trisynaptic circuit through the hippocampus, exhibit low spontaneous firing rates even during locomotion. Using intracellular recordings from dentate neurons in awake mice operating a levitated spherical treadmill, we found a transient membrane potential a-band oscillation associated with the onset of spontaneous motion, especially forward walking movements. While often subthreshold, a oscillations could regulate spike timing during locomotion and may enable dentate gyrus neurons to respond to specific cortical afferent pathways while maintaining low average firing rates.[Supplemental material is available for this article.]Many diverse brain activity states are associated with network oscillations, typically recorded using field potential electrodes or by following the spiking activity of many neural units simultaneously (Buzsáki et al. 1983;Buzsáki 2010). Movement-related oscillations have been studied in a variety of species, especially in rodents which display place-related neural information that can be decoded by analyzing spike timing within nested u and g-band oscillations (O'Keefe 1976;Buzsáki 2010). Little is known, however, about the specific pattern of subthreshold membrane potential modulation-reflecting the synaptic input and the specific intrinsic electrophysiological properties of each neuron-that gives rise to the pattern of spiking output in behaving animals. The intracellular correlate of network oscillations is of special interest in the dentate gyrus (DG) where most neurons maintain very low average firing rates despite robust modulation by locomotion-related oscillations (Neunuebel and Knierim 2012).The recent application of patch-clamp recording methods to awake, head-fixed rodents (Harvey et al. 2009) has enabled direct recording of membrane potential modulation during many behaviors, including locomotion. Through recording intracellular potentials in DG neurons during short spontaneous movements, we found evidence for transient subthreshold a-band oscillation associated with movement onset that modulates firing probability. By continuously varying the intracellular membrane potential, subthreshold oscillations likely play an important role in maintaining sparse firing patterns in output neurons while enabling integration of information from cortical afferent pathways.We recorded from 18 DG neurons with overshooting action potentials (APs) using blind whole-cell patch-clamp methods in awake mice that were conditioned to be head-restrained on a spherical treadmill (Harvey et al. 2009;Youngstrom and Strowbridge 2012) to assess intracellular responses during epochs of spontaneous movement (see Supplemental Methods for details). While these data set likely contained dentate granule cells and interneurons, the relatively low yield of recovering dye-filled neurons and overlapping intrinsic properties precluded a robust classification of ...

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supporting

confidence: 51%

α-Band oscillations in intracellular membrane potentials of dentate gyrus neurons in awake rodents

Anderson

Strowbridge

2014

Learn. Mem.

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“…One limitation with current fMRI approaches is their sluggish temporal resolution (collecting a whole brain volume can take 1-3 seconds), which makes it difficult to evaluate changes in emotion processing to discrete affective events. Currently, EEG (Brown et al, 2012) and MEG (Kerr et al, 2011) approaches offer the best temporal resolution for testing these unexplored areas, and are exciting areas for future research.…”

Section: How Does Mindful Awareness Impact Neural Affective Responsesmentioning

confidence: 99%

The Emerging Neurobiology of Mindfulness and Emotion Processing

Sayers

Creswell

Taren

2015

Handbook of Mindfulness and Self-Regulation

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Mindfulness is associated with reduced negative affective states, increased positive affective states, and reduced clinical affective symptomatology (e.g., depression, anxiety) in previous studies. This chapter examines an emerging body of fMRI and EEG research exploring how mindfulness alters neurobiological emotion processing systems. We examine how dispositional (trait) mindfulness and how adopting a mindful attentional stance (after varying levels of mindfulness training) relate to changes in neural responses to affective stimuli.Evidence suggests mindfulness-related changes in a ventral affective processing network associated with core affect, a dorsal processing network associated with making attributions and appraisals of one's affective experience, and regulatory networks involved in modulating affective processes. These neural effects may underlie the previously observed relationships between mindfulness and changes in reported emotion processing and reactivity. Findings are discussed in light of existing neurobiological models of emotion and we describe important questions for the field in the coming years. NEUROBIOLOGY OF MINDFULNESS AND EMOTION PROCESSING 2 The Emerging Neurobiology of Mindfulness and Emotion ProcessingAn emerging body of research suggests that mindfulness is associated with self-reported and clinically relevant changes in emotion processing. Self-report measures of dispositional mindfulness are associated with reduced negative affective states and positively associated with positive affective states and traits (Brown, Ryan, & Creswell, 2007). Moreover, mindfulnessbased interventions reduce depressive symptomatology and depression-relapse in at-risk patients (Hofmann, Sawyer, Witt, & Oh, 2010;Teasdale et al., 2000), anxiety symptoms (Hofmann, Sawyer, Witt, & Oh, 2010; Kabat-Zinn et al., 1992;Roemer, Orsillo, & Salters-Pedneault, 2008), and affective disturbances in chronic pain patients (Grossman, Tiefenthaler-Gilmer, Raysz, & Kesper, 2007;Kabat-Zinn, 1982). This body of work suggests that mindfulness may be associated with changes in emotion processing, and in this chapter we consider the extant mindfulness fMRI and EEG research to better understand how the brain processes affective stimuli in relation to trait mindfulness, while adopting a mindful attentional stance, and after mindfulness training. Neurobiological Models of Mindfulness and Emotion ProcessingNeurobiological models of emotion processing describe a ventral "core affective" system responsible for establishing the threat or reward value of a stimulus, and a more dorsal affect processing system responsible for appraisals and attributions of one's emotional state (Barrett, Mesquita, Ochsner, & Gross, 2007;Phillips, Drevets, Rauch, & Lane, 2003). While regions of affective processing systems overlap somewhat, the ventral system for core affect has been described as including temporal lobe structures (including the amygdala), insula, anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), and ventromedial prefr...

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“…3 j U l i o -se P t i e m B r e 2014 rante la meditación tales como la corteza cingulada anterior, la ínsula, la corteza temporo-parietal y la red fronto-límbica (Brewer et al, 2011;Holzel et al, 2010;Holzel et al, 2011;Holzel et al, 2013;Kerr, Sacchet, Lazar, Moore & Jones, 2013;Kerr et al, 2011;Lazar et al, 2005;Singleton et al, 2014;Vanhaudenhuyse et al, 2011). Desde el punto de vista comportamental, estos nuevos circuitos podrían servir al aumento del control de las respuestas emocionales y la consecuente disminución de la activación del eje HPA.…”

Section: Estrés Y Psicoterapiaunclassified

Efectos del estrés sobre los procesos de plasticidad y neurogénesis: una revisión

Zarate¹,

Parra²,

Acevedo-Triana

et al. 2014

Univ Psychol

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r e S u M e n Grandes esfuerzos han sido llevados a cabo para entender los componentes psicobiológicos del estrés y de algunas de las psicopatologías relacionadas con él, tales como los trastornos de ansiedad (ansiedad generalizada o crisis de pánico) e incluso la depresión. Existen evidencias de que procesos como la neurogénesis y la plasticidad se ven enormemente afectados por muchos factores, entre ellos el estrés. En esta revisión se presentan algunos de los principales conceptos sobre la relación entre estrés, plasticidad y neurogé-nesis, a los que se ha llegado a partir de investigaciones realizadas -principalmente en modelos animales-, desde hace algunas décadas. Se realizará una diferenciación entre los efectos ocasionados por estrés crónico y agudo, tratando de establecer las interacciones que sobre estos efectos ejercen algunas variables tales como el género o el rango de edad, se enfatizarán los efectos comportamentales para finalmente revisar algunas de las formas de intervención actualmente más usadas para el tratamiento del estrés. Palabras clave estrés; plasticidad; neurogénesis a B S t r a C tThere is a growing interest in the comprehension of psychobiological mechanisms underlying stress and its relationships with many psychopathologies such as anxiety (i.e. generalized anxiety and panic attacks) or depression. There are several reports on the effects of stress on neurogenesis and plasticity. This review will discuss some of the core concepts on the relation between stress, plasticity and neurogenesis obtained during the last decades from research -mainly based in the use of animal models. The distinguishable effects between acute and chronic stress will also be discussed in relation to other factors as genre and age with an emphasis on behavioral effects. Some current therapeutic approaches will be reviewed as well.

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Effects of mindfulness meditation training on anticipatory alpha modulation in primary somatosensory cortex

Cited by 107 publications

References 49 publications

α-Band oscillations in intracellular membrane potentials of dentate gyrus neurons in awake rodents

α-Band oscillations in intracellular membrane potentials of dentate gyrus neurons in awake rodents

The Emerging Neurobiology of Mindfulness and Emotion Processing

Efectos del estrés sobre los procesos de plasticidad y neurogénesis: una revisión

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