Effects of mimosine on Wolbachia in mosquito cells: cell cycle suppression reduces bacterial abundance

Fallon, Ann M.

doi:10.1007/s11626-015-9918-7

Cited by 7 publications

(5 citation statements)

References 32 publications

(26 reference statements)

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“…3). We hypothesize that mimosine may have a major function as anti-cell proliferation of male germ cells since previous reports have demonstrated in other system about theinhibitory activities of many cancer cells, cell divisions, cell proliferations and differentiations, herbicidal, insecticide, and nematicide activities (Tawada, 1990;Wang et al;Hughes & Cook;Krude;Chung et al;Park et al;Bottini-Luzardo et al;Fallon;Nguyen & Tawata). Similar to others, the testicular histopathology, such as atrophic and germ cell degenerating seminiferous tubules, damaged by mimosine in this study was also comparable to other anti-cellular division drug demonstrated previously (Iamsaard et al, 2014;Sukhorum et al, 2016;Iamsaard et al, 2017a,b;Sampannang et al, 2017).…”

Section: Discussionmentioning

confidence: 79%

“…In addition, mimosine is responsible for herbicidal, insecticide, and nematicide activities (Tawata, 1990;Nguyen & Tawata, 2015). Indeed, mimosine also can arrest the cell cycle progression to inhibit cell proliferation of many cancer cells (Chung et al, 2012;Park et al, 2012;Bottini-Luzardo et al, 2015;Fallon, 2015;Nguyen & Tawata;Kacar et al, 2017). To provide the basic information to caution people about subfertility or infertility effects from acute consumption of the LL parts containing natural mimosine; therefore, this study attempted to investigate the acute effects of purified mimosine extracted from Leucaenaleucocephala on reproductive system in male mice.…”

Section: Introductionmentioning

confidence: 99%

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Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice

Kanla¹,

Burawat²,

Arun³

et al. 2018

Int. J. Morphol.

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KANLA, P.; BURAWAT, J.; ARUN, S.; SAWATPANICH, T.; CHAICHUN, A. & IAMSAARD, S. Acute effects of mimosine purified from Leucaena leucocephala on male reproductive system of adult mice. Int. J. Morphol., 36(2):507-512, 2018. SUMMARY. This study attempted to examine the acute effect of purified minosine extracted from Leucaena leucocephala on male reproductive system. Adults male mice were divided into 4 groups (n =8); control and 3 experimental groups treated with purified mimosine at different doses of 15, 30, and 60 mg/KgBW, respectively for 7 consecutive days. The morphological features and weights of body and reproductive organs including testis, epididymis plus vas deferens, and seminal vesicle were compared among groups. In addition, epididymal sperm concentration and the changes of histopathology of testicular tissues in all groups were observed. The results showed that mimosine in all doses did not affect mice body weights. However, all doses of mimosine could significantly reduce the absolute and relative weights of testis and seminal vesicle but not of epididymis plus vas deferens. Significantly, mimosine at doses of 30, and 60 mg/KgBw could decrease sperm concentration. Moreover, the seminiferous atrophy and degeneration were obviously found in mimosine treated mice as compared to the control. In conclusion, consumption of Leucaena leucocephala edible parts containing mimosine could damage male reproductive organs which may cause acute male subfertility or infertility. KANLA, P.; BURAWAT, J.; ARUN, S.; SAWATPANICH, T.; CHAICHUN, A. & IAMSAARD, S. Acute effects of mimosine purified from Leucaena leucocephala on male reproductive system of adult mice. Int. J. Morphol., 36(2):507-512, 2018.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice

Kanla¹,

Burawat²,

Arun³

et al. 2018

Int. J. Morphol.

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“…between G 1 and S phases [106] (Perennes et al, 1993), which is consistent with the inhibition of cell division of Pisum sativum radicles and Zea mays roots by the aqueous extracts of L. leucocephala [58,59], as described in the previous section. It was also reported to block cell division in mammalian and insect cells, blocking entry into S phase from late G 1 phase and suppressing elongation of DNA replication (S phase) [89,[108][109][110][111]. The activities of nitrate reductase, peroxidase, catalase, and IAA oxidase were inhibited by mimosine treatments in Oryza sativa L. seedling [112].…”

Section: Mimosinementioning

confidence: 99%

Allelopathy and Allelochemicals of Leucaenaleucocephala as an Invasive Plant Species

Kato‐Noguchi

Kurniadie

2022

Plants

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Leucaena leucocephala (Lam.) de Wit is native to southern Mexico and Central America and is now naturalized in more than 130 countries. The spread of L. leucocephala is probably due to its multipurpose use such as fodder, timber, paper pulp, shade trees, and soil amendment. However, the species is listed in the world’s 100 worst invasive alien species, and an aggressive colonizer. It forms dense monospecific stands and threatens native plant communities, especially in oceanic islands. Phytotoxic chemical interactions such as allelopathy have been reported to play an important role in the invasion of several invasive plant species. Possible evidence for allelopathy of L. leucocephala has also been accumulated in the literature over 30 years. The extracts, leachates, root exudates, litter, decomposing residues, and rhizosphere soil of L. leucocephala increased the mortality and suppressed the germination and growth of several plant species, including weeds and woody plants. Those observations suggest that L. leucocephala is allelopathic and contains certain allelochemicals. Those allelochemicals may release into the rhizosphere soil during decomposition process of the plant residues and root exudation. Several putative allelochemicals such as phenolic acids, flavonoids, and mimosine were identified in L. leucocephala. The species produces a large amount of mimosine and accumulates it in almost all parts of the plants, including leaves, stems, seeds, flowers, roots, and root nodules. The concentrations of mimosine in these parts were 0.11 to 6.4% of their dry weight. Mimosine showed growth inhibitory activity against several plant species, including some woody plants and invasive plants. Mimosine blocked cell division of protoplasts from Petunia hybrida hort. ex E. Vilm. between G1 and S phases, and disturbed the enzyme activity such as peroxidase, catalase, and IAA oxidase. Some of those identified compounds in L. leucocephala may be involved in its allelopathy. Therefore, the allelopathic property of L. leucocephala may support its invasive potential and formation of dense monospecific stands. However, the concentrations of mimosine, phenolic acids, and flavonoids in the vicinity of L. leucocephala, including its rhizosphere soil, have not yet been reported.

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“…Currently, there are two well‐known modes of action of mimosine on the cell cycle: (i) blocking entry into S phase (late G1 phase), and (ii) suppressing elongation of DNA replication (S phase). In mammalian cells, mimosine has been suggested to arrest the cell cycle in the late G1 phase (Lalande, ; Watson et al ., ; Hoffman et al ., ; Yin et al ., ; Andreassen and Margolis, ; Ryan et al ., ; Kubota et al ., ; Fallon, ), and for this reason, it has been utilized as synchronization agent in an attempt to clarify the biochemical events that trigger the initiation of S phase (Yoshida et al ., ; Ouhibi et al ., ; Kulp and Vulliet, ). This drug has been also put forward to prevent the progression of the cell cycle after entering the S phase (Hughes and Cook, ); specifically the initiation of new replicons (Dijkwel and Hamlin, ; Mosca et al ., ; Tsvetkov et al ., ) and elongation of progeny DNA replication.…”

Section: Mimosine and Cell Cycle Blockingmentioning

confidence: 99%

The Chemistry and Biological Activities of Mimosine: A Review

Nguyen

Tawata

2016

Phytotherapy Research

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Mimosine [β-[N-(3-hydroxy-4-oxypyridyl)]-α-aminopropionic acid] is a non-protein amino acid found in the members of Mimosoideae family. There are a considerable number of reports available on the chemistry, methods for estimation, biosynthesis, regulation, and degradation of this secondary metabolite. On the other hand, over the past years of active research, mimosine has been found to have various biological activities such as anti-cancer, antiinflammation, anti-fibrosis, anti-influenza, anti-virus, herbicidal and insecticidal activities, and others. Mimosine is a leading compound of interest for use in the development of RAC/CDC42-activated kinase 1 (PAK1)-specific inhibitors for the treatment of various diseases/disorders, because PAK1 is not essential for the growth of normal cells. Interestingly, the new roles of mimosine in malignant glioma treatment, regenerative dentistry, and phytoremediation are being emerged. These identified properties indicate an exciting future for this amino acid. The present review is focused on the chemistry and recognized biological activities of mimosine in an attempt to draw a link between these two characteristics. Copyright © 2016 John Wiley & Sons, Ltd.

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Effects of mimosine on Wolbachia in mosquito cells: cell cycle suppression reduces bacterial abundance

Cited by 7 publications

References 32 publications

Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice

Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice

Allelopathy and Allelochemicals of Leucaenaleucocephala as an Invasive Plant Species

The Chemistry and Biological Activities of Mimosine: A Review

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