Effects of microinjection of angiotensin II and captopril to VTA on morphine self-administration in rats

Hosseini, M; Alaei, Hojjatallah; Havakhah, Shahrzad; Karimooy, H. A. Neemati; Gholamnezhad, Zahra

doi:10.1556/abiol.60.2009.3.1

Cited by 13 publications

(12 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and xylazine (0.1 mg/ kg, i.p.) anesthesia (31). Anesthesia was confirmed by reduced respiratory rate and lack of no response to a gentle pinching of the foot pad.…”

Section: Ovariectomymentioning

confidence: 99%

Inducible nitric oxide synthase inhibitor aminoguanidine, differently affects Morris water maze tasks of ovariectomized and naïve female rats

Hosseini¹,

Karimooy²,

Hadjzadeh³

et al. 2011

Acta Physiologica Hungarica

View full text Add to dashboard Cite

The role of ovarian hormones, nitric oxide, and their interaction on learning and memory has been widely investigated. The objective of present study was to investigate different effects of chronic administration of inducible nitric oxide synthase inhibitor, aminoguanidine (AM) on learning and memory of ovariectomized (OVX) and naïve (Sham) female rats. Thirty-two rats were divided into four groups: 1) Sham, 2) OVX, 3) Sham-AM and 4) OVX-AM. The animals of Sham-AM and OVX-AM chronically received 100 mg/kg/day of aminoguanidine during 8 weeks before 5 test days. The animals in Sham and OVX groups received 1 ml/kg saline instead of aminoguanidine. The animals were tested in Morris water maze and the escape latency and traveled path to reach the platform were compared between groups. On the fifth day, the platform was removed, and the animals were allowed to swim for 60 s ( prob trial). The time spent in the target quadrant (Q1) was compared between groups.Results showed that the escape latency and traveled path in OVX group were significantly higher than in the Sham group (p<0.01). Both escape latency and traveled path in the Sham-AM group was significantly higher than in the Sham group (p<0.01) however, there was no significant difference between OVX-AM and OVX groups.The time spent by the animals of OVX group in the target quadrant (Q1) during the probe trial was significantly lower than that in the Sham group (p<0.01). The animals of the Sham-AM group spent shorter times in the target quadrant in comparison with the Sham group (p<0.01). There was no significant difference between the OVX and OVX-AM groups in the time spent in tarthe get quadrant. It is concluded that the effect of aminoguanidine on learning and memory is different in the presence or absence of ovarian hormones but it needs further investigation.

show abstract

“…and xylazine (0.1 mg/ kg, i.p.) anesthesia (31). Anesthesia was confirmed by reduced respiratory rate and lack of no response to a gentle pinching of the foot pad.…”

Section: Ovariectomymentioning

confidence: 99%

Inducible nitric oxide synthase inhibitor aminoguanidine, differently affects Morris water maze tasks of ovariectomized and naïve female rats

Hosseini¹,

Karimooy²,

Hadjzadeh³

et al. 2011

Acta Physiologica Hungarica

View full text Add to dashboard Cite

show abstract

“…In chronic Ang II-infusion hypertension model, Ang II causes increased sympathetic activity[ 57 ] and this effect of Ang II has been decreased by Est treatment. [ 29 30 ] Because in DOCA salt hypertension also sympathetic activity increased by Ang II, another possible effect of Est is interacting with Ang II in modulation of sympathetic activity evoked by DOCA- salt hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…The animals were ovariectomized under ketamine anesthesia (150 mg/kg and xylazine 0.1 mg/kg i.p). [ 30 31 ] The abdomens were exposed and the ovaries and ovarian fats were removed. The same procedure was performed on Sham rats except that the wound was closed without removing the ovaries.…”

Section: Methodsmentioning

confidence: 99%

Interaction of central Angiotensin II and estrogen on systolic blood pressure in female DOCA-salt treated rats

et al. 2016

View full text Add to dashboard Cite

Background:There is a probable interaction of central angiotensin II (Ang II) and estrogen (Est) on blood pressure in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Therefore, in the present study, the interaction between Ang II and Est in ovariectomized (Ovx) and Sham rats that were treated with DOCA- salt was evaluated.Materials and Methods:The female rats were divided into 10 groups as follows: Sham, Ovx, Sham-DOCA, Ovx-DOCA, Sham-DOCA-estrogen (E), Ovx DOCA-E, Sham-DOCA-losartan (L), Ovx-DOCA-L, Sham–DOCA-L-E, and Ovx-DOCA-L-E. The Est groups received estradiol valerate (2 mg/kg; daily; subcutaneously (s.c)) for four weeks. Following that, several doses of Ang II (0.5, 5, 50, 500, 5000 ng/5 μl) were injected via the intracerebroventricular (i.c.v) route and the changes in systolic blood pressure (SBP) were evaluated. In the losartan groups, 200 μg losartan was injected (i.c.v) 15 minutes after the Ang II injection and the blood pressure was recorded. Treatment by DOCA was performed by removal of one kidney, injection of DOCA (45 mg/kg i.p), and adding of sodium chloride (NaCl) (1%) and potassium chloride (KCl) (0.1%) in the drinking water.Results:The SBP was increased by Ang II and this effect in DOCA-salt treated rat was higher than in the untreated groups. The effect of Ang II on SBP in groups that were treated with Est and L was lower than that in the DOCA-salt groups. Increase in SBP was strongly attenuated by Ang II in groups that were co-treated with both Est and L compared to the DOCA-treated rats. These results showed that Est significantly attenuated the effect of central Ang II on SBP in the DOCA-salt treated rats.Conclusion:We suggest that there are interactions between E and Ang II in the control of blood pressure in DOCA-salt treated rats.

show abstract

“…Rats were anesthetized with ketamine (150 mg/kg) and xylazine (0.1 mg/kg) 20 . Anesthesia was confirmed by reduced respiratory rate and no response to gentle pinching of footpad.…”

Section: Surgerymentioning

confidence: 99%

Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol

Sadeghian

Fereidoni

Soukhtanloo

et al. 2012

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

The effects of a high estradiol dose on memory and on nitric oxide metabolites in hippocampal tissues were investigated. Sham-Est and OVX-Est Groups were treated with 4 mg/kg of estradiol valerate for 12 weeks. Time latency and path length were significantly higher in the Sham-Est and OVX-Est Groups than in the Sham and OVX Groups, respectively (p<0.001). The animals in the Sham-Est and OVX-Est Groups spent lower time in the target quadrant (Q1) than those of the Sham and OVX Groups during the probe trial test (p<0.05 and <0.001, respectively). Significantly lower nitric oxide metabolite levels in the hippocampi of the Sham-Est and OVX-Est Groups were observed than in the Sham and OVX ones (p<0.001). These results suggest that decreased nitric oxide levels in the hippocampus may play a role in the learning and memory deficits observed after treatment with a high dose of estradiol, although the precise underlying mechanisms remain to be elucidated.

show abstract

Effects of microinjection of angiotensin II and captopril to VTA on morphine self-administration in rats

Cited by 13 publications

References 45 publications

Inducible nitric oxide synthase inhibitor aminoguanidine, differently affects Morris water maze tasks of ovariectomized and naïve female rats

Inducible nitric oxide synthase inhibitor aminoguanidine, differently affects Morris water maze tasks of ovariectomized and naïve female rats

Interaction of central Angiotensin II and estrogen on systolic blood pressure in female DOCA-salt treated rats

Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol

Contact Info

Product

Resources

About