Effects of microcystin-LR on mouse lungs

Soares, Raquel; Cagido, Viviane Ramos; Ferraro, Rodrigo B.; Meyer‐Fernandes, José Roberto; Rocco, Patrícia Rieken Macêdo; Zin, Walter A.; Azevedo, Sandra M.F.O.

doi:10.1016/j.toxicon.2007.04.003

Cited by 57 publications

(28 citation statements)

References 35 publications

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“…injection. Soares et al (2007) found that MC-LR led to a rapid increase in lung impedance and an inflammatory response with interstitial edema and inflammatory cell recruitment in mice after exposure to 40 mg/kg toxins. The above studies focused on documenting the toxicity of MCs on lung but information on the distribution of MCs in lung was limited.…”

Section: C]mc-lrmentioning

confidence: 94%

“…MCs are known to be not only responsible for the damage of hepatic and renal function (Nobre et al, 2001(Nobre et al, , 2003, but also for the pathological changes of respiratory system (Ito et al, 2001;Pican et al, 2004;Soares et al, 2007). Pican et al (2004) reported that cyanobacterial compounds containing MCs caused various histological changes in the lung of Swiss mice after i.p.…”

Section: C]mc-lrmentioning

confidence: 99%

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Distribution of microcystins in various organs (heart, liver, intestine, gonad, brain, kidney and lung) of Wistar rat via intravenous injection

Wang

Xie

Chen

et al. 2008

Toxicon

110

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Section: C]mc-lrmentioning

confidence: 94%

Section: C]mc-lrmentioning

confidence: 99%

Distribution of microcystins in various organs (heart, liver, intestine, gonad, brain, kidney and lung) of Wistar rat via intravenous injection

Wang

Xie

Chen

et al. 2008

Toxicon

110

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“…In addition, some studies described in vivo toxic effects of MCLR in the kidney (Nobre et al, 1999;Milutinović et al, 2002Milutinović et al, , 2003, intestine (Botha et al, 2004;Gaudin et al, 2008), brain (Maidana et al, 2006), lungs (Soares et al, 2007) and reproductive system (Ding et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Microcystin-LR activates the ERK1/2 kinases and stimulates the proliferation of the monkey kidney-derived cell line Vero-E6

Dias

Matos

Pereira

et al. 2010

Toxicology in Vitro

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a b s t r a c tMicrocystin-LR (MCLR) is a peptide produced by freshwater cyanobacteria that induces severe hepatotoxicity in humans and animals. MCLR is also a potent tumour promoter and it has been proposed that this activity is mediated by the inhibition of protein phosphatases PP1/PP2A, possibly through the activation of proto-oncogenes c-jun, c-fos and c-myc. However, the mechanisms underlying MCLR-induced tumour promotion are still largely unknown, particularly in non-liver cells. In previous studies we have demonstrated that micromolar concentrations of MCLR induce cytotoxic effects in the kidney Vero-E6 cell line. The purpose of the present work was to evaluate whether the exposure to subcytotoxic concentrations of MCLR was sufficient to induce the proliferation of Vero-E6 cells. Through BrdU incorporation assay we show that at nanomolar concentrations MCLR stimulates cell cycle progression in Vero-E6 kidney cell line. Moreover, the analysis of mitogen-activated protein kinases p38, JNK and ERK1/2 activity revealed that the proliferative effect of MCLR is associated with the activation of the pro-proliferative ERK1/2 pathway. These results emphasise the importance to confirm in vivo the impact of MCLR on tumour promotion at kidney level.

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“…MARIA DO CARMO BITTENCOURT-OLIVEIRA et al which act by inflicting damage to cells from the liver and other organs (Soares et al 2007), possibly leading the organisms to death by hemorrhagic shock (Mackintosh et al 1990, Hooser et al 1991. Moreover, at sub-lethal doses, these toxins might act as tumor promoters (Ueno et al 1996, Ding et al 1999, zhou et al 2002.…”

mentioning

confidence: 99%

Cyanobacteria, microcystins and cylindrospermopsin in public drinking supply reservoirs of Brazil

Bittencourt‐Oliveira

Piccin-Santos

Moura

et al. 2014

An. Acad. Bras. Ciênc.

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Brazil has a history of blooms and contamination of freshwater systems by cyanobacterial toxins. The monitoring relevance of toxins from cyanobacteria in reservoirs for public supply is notorious given its high toxicity to mammals, included humans beings. The most recurrent toxins in Brazilian water bodies are microcystins (MC). However, the recent record of cylindrospermopsin (CyN) in northeastern Brazil, Pernambuco state, alerts us to the possibility that this could be escalating. This study reports occurrence of MC and CYN, quantified with ELISA, in 10 reservoirs, devoted to public drinking supply in northeastern Brazil. The composition and quantification of the cyanobacteria community associated with these water bodies is also presented. From 23 samples investigated for the presence of MC, and CyN, 22 and 8 out were positive, respectively. Considering the similarity of the cyanobacteria communities found in reservoirs from Pernambuco, including toxin-producing species associated to MC and CyN, we suggest that geographic spreading can be favored by these factors. These issues emphasize the need for increased monitoring of MC and CyN in drinking supply reservoirs in Brazil.

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Effects of microcystin-LR on mouse lungs

Cited by 57 publications

References 35 publications

Distribution of microcystins in various organs (heart, liver, intestine, gonad, brain, kidney and lung) of Wistar rat via intravenous injection

Distribution of microcystins in various organs (heart, liver, intestine, gonad, brain, kidney and lung) of Wistar rat via intravenous injection

Microcystin-LR activates the ERK1/2 kinases and stimulates the proliferation of the monkey kidney-derived cell line Vero-E6

Cyanobacteria, microcystins and cylindrospermopsin in public drinking supply reservoirs of Brazil

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