Effects of methyluracil and hydroxymethacil on free-radical oxidation in model systems

Abstract

Three pyrimidine derivatives -methyluracil, hydroxymethacil (a new compound), and its lithium salt -were tested in model systems of differing complexity for antioxidant properties in comparison with the well-known antioxidant ionol. Tests for antiradical activity and for effects on spontaneous and Fe2+-ascorbate -or NADPH-dependent lipid peroxidation revealed high antioxidant activity (comparable to that of ionol) of the hydroxymethacil lithium salt.

Correction of morphological shifts in experimental syringomyelia

“…For example, pronounced antioxidant, regeneratory, and antitoxic effects of HMU were described [2]. The use of antioxidants and nucleotide derivatives as neuroprotectors in neurological diseases showed their efficiency [4,6,7].…”

Experimental study of hepatoprotective activity of hydroxymethyluracil

“…A wide range of biological activity is also typical of derivatives of various natural nucleic acids, including HMU. Published data show that HMU has antioxidant, antitoxic, regenerative, and antiinflammatory properties [4,5]. HMU (Immureg) is recommended as an immunomodulatory drug.…”