Effects of methylphenidate on memory functions of adults with ADHD

Fuermaier, Anselm B. M.; Tucha, Lara; Koerts, Janneke; Weisbrod, Matthias; Lange, Klaus W.; Aschenbrenner, Steffen; Tucha, Oliver

doi:10.1080/23279095.2015.1124108

Cited by 37 publications

(37 citation statements)

References 73 publications

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“…Meta-analyses revealed that inhibition, working memory, cognitive flexibility and fluency tasks were most robustly impaired in adults with ADHD with effect sizes reaching moderate size (Alderson et al, 2013;Boonstra et al, 2005;Hervey et al, 2004;Schoechlin & Engel, 2005). Furthermore, neuropsychological research on adults with ADHD also demonstrated small to medium impairments in several aspects of learning and memory (Fuermaier et al, 2016;Kaplan, Dewey, Crawford, & Fisher, 1998;Muir-Broaddus, Rosenstein, Medina, & Soderberg, 2002;Pollak, Kahana-Vax, & Hoofien, 2008;Seidman, 2006). Deficits occur particularly in those memory functions that strongly rely on intact executive control, which suggests an involvement of executive dysfunctions in disturbed memory functioning of adults with ADHD (Altgassen, Kretschmer, & Kliegel, 2014;Fuermaier, Tucha, Koerts, Aschenbrenner, Westermann, et al, 2013;Pollak et al, 2008;White & Marks, 2004).…”

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confidence: 96%

Neuropsychological assessment of adults with ADHD: A Delphi consensus study

Fuermaier

Fricke

Vries

et al. 2018

Applied Neuropsychology: Adult

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Within the clinical evaluation of adults with attention deficit hyperactivity disorder (ADHD), cognitive functions are often assessed to characterize individual cognitive problems and guide treatment planning. However, the composition of an adequate neuropsychological assessment battery remains difficult given the large number of cognitive functions that can be distinguished, the variety of available tools to assess these functions, as well as the cognitive heterogeneity that has been observed between individuals with ADHD. Twenty-seven clinicians and researchers experienced in working with adults with ADHD took part in the present study. This study employed the Delphi methodology in order to compose an assessment battery for the measurement of the most important neuropsychological functions by employing the most suitable measures to assess these functions. Consensus between experts was achieved on a ranking of 16 neuropsychological functions that are important for the neuropsychological assessment of adults with ADHD. Furthermore, measures were suggested to assess each of the neuropsychological functions. The assessment battery as composed in the present study may support research and clinical practice in the selection of appropriate functions and measures for the determination of the individual level of cognitive functioning and treatment planning of adults with ADHD.

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confidence: 96%

Neuropsychological assessment of adults with ADHD: A Delphi consensus study

Fuermaier

Fricke

Vries

et al. 2018

Applied Neuropsychology: Adult

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“…In zahlreichen Studien bei ADHS-Betroffenen konnten positive Effekte auf die Aufmerksamkeit und die Vigilanzfunktion, das Arbeitsgedächtnis, das Langzeitgedächtnis, die Handlungsplanung (35),die kognitive Flexibilität und die Inhibition bei mindestens 70% der untersuchten Probanden gezeigt werden. Dabei ist die, dosisabhängige, erwünschte Wirkung bei den komplexeren Funktionen, wie zum Beispiel der Handlungsplanung, der kognitiven Flexibilität und der Inhibition weniger beobachtbar (36,37).…”

Section: Pharmakotherapeutisches Satellitenforumunclassified

Die Behandlung der ADHS im Erwachsenenalter mit retardiertem Methylphenidat

Ahlers¹

2016

Die Psychiatrie

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ZusammenfassungDie Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) im Erwachsenenalter ist mit verhaltensbezogenen und psychopharmakologischen Maßnahmen symptomatisch behandelbar. Die Ätiologie der Störung ist noch nicht zur Gänze geklärt, wobei genetische Faktoren einen großen Stellenwert einnehmen. Neurobiologisch wird ein Defizit dopaminerger und noradrenerger Funktionen modellhaft angenommen. Zur pharmakologischen Behandlung stehen mehrere Substanzen zur Verfügung. Zugelassen sind aktuell in Deutschland zur Neueinstellung im Erwachsenenalter retardierte Methylphenidate (Medikinet® adult, Ritalin® adult) und Atomoxetin (Strattera®). Eine Behandlung mit Methylphenidat retard gilt als erste Wahl. Methylphenidat wird dabei die Wirkung im Sinne eines starken Dopamin- und Noradrenalin-Wiederaufnahmehemmers als ursächlich für den therapeutischen Effekt zugeschrieben. Unerwünschte Wirkungen in der Behandlung mit Methylphenidat ergeben sich vordringlich aus den sympathomimetischen peripheren Effekten. An ein Missbrauchspotenzial und mögliche depressiogene Effekte sollte gedacht werden. Daten aus Langzeitstudien lassen bei guter Verträglichkeit auf eine zuverlässige positive Wirkung auf die Kernsymptomatik, den Komorbiditätsstatus sowie auf assoziierte Probleme bei ADHS schließen. Es besteht weiterhin großer Forschungsbedarf was die Ursachen der Störung sowie die genaue Wirkungsweise der Substanzen angeht.

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“…Adults with ADHD typically demonstrate impairments in a variety of cognitive abilities, such as sustained attention, executive functioning, and response inhibition (Asherson, 2005). Long-term memory problems mainly in the verbal memory domain (the focus of the current study) are a frequently reported symptom in adult ADHD (Fuermaier et al, 2017; for meta-analysis, see Skodzik, Holling, & Pedersen, 2017).…”

Section: Introductionmentioning

confidence: 98%

Production Effect in Adults With ADHD With and Without Methylphenidate (MPH): Vocalization Improves Verbal Learning

Mama

Icht

2018

J Int Neuropsychol Soc

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Objectives: Reading aloud (vocal production) enhances memory relative to reading silently, the Production Effect (PE) in memory. Thus, vocalization has been suggested as a mnemonic device. The current study tested the PE in a sample of adults with ADHD and in a control sample, evaluating verbal learning. Methods: Twenty adults with ADHD and 21 controls learned a list of words, half by reading aloud and half by reading silently. Free recall test followed. The participants with ADHD performed the task twice (in two different sessions in a counterbalanced order), before self-administration of a single dose of methylphenidate (MPH) and 60-min after dosage. Results: PEs were found for all groups. Memory was better for the controls than for the ADHD group (with or without MPH). In the ADHD group, recall rates and the PE were higher with than without MPH. Conclusions: These results suggest that vocalization yields a larger memory gain with MPH. Possibly, MPH enables the ADHD participants to better shift their attention to the aloud words, enhancing their retrieval rates. Theoretically, these findings stress the role of attention in the PE. (JINS, 2019, 25, 230–235)

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Effects of methylphenidate on memory functions of adults with ADHD

Cited by 37 publications

References 73 publications

Neuropsychological assessment of adults with ADHD: A Delphi consensus study

Neuropsychological assessment of adults with ADHD: A Delphi consensus study

Die Behandlung der ADHS im Erwachsenenalter mit retardiertem Methylphenidat

Production Effect in Adults With ADHD With and Without Methylphenidate (MPH): Vocalization Improves Verbal Learning

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