Effects of methylphenidate in ADHD adults on target evaluation processing reflected by event-related potentials

Ohlmeier, Martin D.; Prox, Vanessa; Zhang, Yuanyuan; Zedler, Markus; Ziegenbein, Marc; Emrich, H. M.; Dietrich, Detlef E.

doi:10.1016/j.neulet.2007.06.055

Cited by 9 publications

(5 citation statements)

References 48 publications

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“…However, as previously reported in Kratz et al (2009), we found distinct medication effects in nogo trials for measures representing motor system excitability. Relating our results to the existing literature dealing with the effects of MPH on ERPs in adults, Ohlmeier et al (2007) and Overtoom et al (2009) did not find any effect of a low dose of MPH (0.4 mg/kg) on the ERPs in adult patients with ADHD, whereas a higher dose (0.6 mg/kg) affected the N1 and the stop-P3 in a stop signal task in the latter study (Overtoom et al, 2009).…”

Section: Mph Effectssupporting

confidence: 81%

Interplay of neuronal processes during response inhibition: Results from a combined event-related potentials (ERPs)/transcranial magnetic stimulation (TMS) study on methylphenidate

Hoegl

Heinrich

Albrecht

et al. 2011

International Journal of Psychophysiology

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Section: Mph Effectssupporting

confidence: 81%

Interplay of neuronal processes during response inhibition: Results from a combined event-related potentials (ERPs)/transcranial magnetic stimulation (TMS) study on methylphenidate

Hoegl

Heinrich

Albrecht

et al. 2011

International Journal of Psychophysiology

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“…This finding corresponds to the results of Hoegl et al () who also found no effect of a single dose of MPH (20 mg) on either N1 or N2. Overtoom et al () and Ohlmeier et al (), however, found no effects using a low dose (0,4 mg/kg) of MPH, but found changes in the N1 and P3 in a stop signal task using a higher dosage (0,6 mg/kg). In the study by Overtoom et al (), MPH was reported to restore the formerly absent N1 and to reduce the P3 in adult subjects with ADHD (Overtoom et al, ).…”

Section: Discussionmentioning

confidence: 96%

“…Partially divergent results were found in a couple of studies with adult patients suffering from ADHD using a stop signal task (Ohlmeier et al, ; Overtoom et al, ). No effect of MPH was found for low doses of MPH (0.4 mg/kg) on any of the ERP.…”

Section: Introductionmentioning

confidence: 99%

Methylphenidate promotes the interaction between motor cortex facilitation and attention in healthy adults: A combined study using event‐related potentials and transcranial magnetic stimulation

et al. 2018

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ObjectiveThis study investigated simultaneously the impact of methylphenidate (MPH) on the interaction of inhibitory and facilitative pathways in regions processing motor and cognitive functions.MethodNeural markers of attention and response control (event‐related potentials) and motor cortical excitability (transcranial magnetic stimulation) and their pharmacological modulation by MPH were measured simultaneously in a sample of healthy adults (n = 31) performing a cued choice reaction test.ResultsMethylphenidate modulated attentional gating and response preparation processes (increased contingent negative variation) and response inhibition (increased nogo P3). N1, cue‐ and go‐P3 were not affected by MPH. Motor cortex facilitation, measured with long‐interval cortical facilitation, was increased under MPH in the nogo condition and was positively correlated with the P3 amplitude.ConclusionMethylphenidate seems particularly to enhance response preparation processes. The MPH‐induced increased motor cortex facilitation during inhibitory task demands was accompanied by increased terminal response inhibition control, probably as a compensatory process.

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“…One could argue that this comorbidity could have contributed to the difference observed in the patient group. It has been repeatedly shown that major depression is related to reduced P300 amplitude and delayed peak latency (Anderer et al, 2002;Blackwood et al, 1987;Gangadhar et al, 1993;Röschke and Wagner, 2003), while other research has shown that hyperactivity fails to significantly affect the P300 component in an adult population (Ohlmeier et al, 2007;Prox et al, 2007). Additional investigations, with OCD patients, also found diminished amplitude and faster P300 peak latency (Towey et al, 1990(Towey et al, , 1993(Towey et al, , 1994.…”

Section: Limitations and Future Directionsmentioning

confidence: 96%

Electrophysiological manifestations of stimulus evaluation, response inhibition and motor processing in Tourette syndrome patients

Thibault

O’Connor

Stip

et al. 2009

Psychiatry Research

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Gilles de la Tourette syndrome (GTS) is a neuropsychiatric disorder with childhood onset presenting with multiple fluctuating motor tics and one or more phonic tics. A significant proportion of people suffering from GTS are still symptomatic in adulthood and present other emotional and cognitive difficulties, along with motor problems that often accompany these comorbid conditions. The nature of these difficulties is still poorly understood and multiple comorbidities are often inadequately controlled. The current study investigates both stimulus evaluation and motor processing in GTS while controlling for comorbidity. Fifteen adults with GTS and 20 control participants were matched on gender, laterality and intelligence. The P300 component, the no-go anteriorization (NGA) as well as the stimulus and response-locked lateralized-readiness potentials (S-LRP, R-LRP) were elicited during a stimulus-response compatibility (SRC) paradigm. The standard version of the Stroop Color-Word Test (SCWT) was also administered. Reaction times showed that participants with GTS processed both the SRC and the SCWT more rapidly than the control group, while producing a delayed P300 peak latency. The GTS group also showed faster S-LRP onset in response to the incompatible and faster processing of interference in the SCWT. There was also a tendency toward a greater frontal shift of the NGA in the GTS group. The P300 latency showed that with GTS patients, stimulus evaluation occurs later whereas the overlapping pre-motor response selection processes occur faster. Our findings are congruent with a probable cortical motor over-activation hypothesis of GTS involving faster motor program selection in processing conflicting SR configuration.

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Effects of methylphenidate in ADHD adults on target evaluation processing reflected by event-related potentials

Cited by 9 publications

References 48 publications

Interplay of neuronal processes during response inhibition: Results from a combined event-related potentials (ERPs)/transcranial magnetic stimulation (TMS) study on methylphenidate

Interplay of neuronal processes during response inhibition: Results from a combined event-related potentials (ERPs)/transcranial magnetic stimulation (TMS) study on methylphenidate

Methylphenidate promotes the interaction between motor cortex facilitation and attention in healthy adults: A combined study using event‐related potentials and transcranial magnetic stimulation

Electrophysiological manifestations of stimulus evaluation, response inhibition and motor processing in Tourette syndrome patients

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