Effects of Methanol Extract of Breadfruit (<i>Artocarpus altilis</i>) on Atherogenic Indices and Redox Status of Cellular System of Hypercholesterolemic Male Rats

Adaramoye, Oluwatosin A.; Akanni, Olubukola

doi:10.1155/2014/605425

Cited by 17 publications

(15 citation statements)

References 46 publications

(48 reference statements)

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“…The potential effects may be predominantly due to the inhibition of rate-limiting enzyme HMG-CoA reductase of cholesterol biosynthesis and improvement in the lipolysis by reducing the activity of hormone sensitive lipase respectively. The lipoproteins, especially LDL-C, are involved in the process of formation of atherosclerotic plaques [38]. The association between a low level of HDL-C and an increased risk of cardiovascular disease has been well established in diabetic patients through epidemiological and clinical studies [39].…”

Section: Discussionmentioning

confidence: 99%

“…The antihyperlipidemic potentials of the three extracts were further confirmed with the results of calculated indices including CPI, AI, and CRI. These indices are powerful indicators in evaluating the risk of cardiovascular diseases especially in diabetic subjects [38]. Higher values of AI and CRI imply higher risk of developing cardiovascular disease and vice versa [38].…”

Section: Discussionmentioning

confidence: 99%

“…These indices are powerful indicators in evaluating the risk of cardiovascular diseases especially in diabetic subjects [38]. Higher values of AI and CRI imply higher risk of developing cardiovascular disease and vice versa [38]. The AI and CRI were higher while CPI was lower in diabetic control rats with compared to healthy control rats.…”

Section: Discussionmentioning

confidence: 99%

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Biochemical and Histological Evaluation of Three Selected Medicinal Plant Extracts of Sri Lankan Origin on Dyslipidemia and Oxidative Stress in Alloxan Induced Diabetic Rats

et al. 2018

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The objective of the present study was to investigate the effect of refluxed aqueous extracts of Gmelina arborea, Spondias pinnata, and Coccinia grandis on atherogenicity and oxidative stress in rats with chemically induced type 1 diabetes mellitus. Alloxan monohydrate (150 mg/kg, intraperitoneal) was used to induce diabetes to Wistar rats. Thereafter, diabetic rats (n=6 per group) were treated with the three selected plant extracts at their optimum effective therapeutic doses and glibenclamide (0.50 mg/kg, positive control) for 30 days. Administration of the three extracts in diabetic rats exhibited antihyperglycemic, antiatherogenic, and antioxidant effects in diabetic rats on the 30th day of the study. The atherogenic and coronary risk indices were also reduced in support of the antiatherogenic effects. The results of the study revealed that the bark extracts of G. arborea, S. pinnata, and leaf extract of C. grandis exerted beneficial effects against dyslipidemia, atherogenicity, and oxidative stress in alloxan induced diabetic rats. The selected plant extracts would be beneficial for the development of food supplements targeting main complications associated with diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Biochemical and Histological Evaluation of Three Selected Medicinal Plant Extracts of Sri Lankan Origin on Dyslipidemia and Oxidative Stress in Alloxan Induced Diabetic Rats

et al. 2018

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“…TBARS assay kit was purchased from Cell Biolabs, Inc. (San Diego, CA 92126, USA). The concentration of low-density lipoprotein (LDL) cholesterol was calculated using the Friedewald equation, while coronary risk indices (CRI = TC/HDL) were also estimated [26]. Admittedly, these estimations are more appropriate to human samples. …”

Section: Methodsmentioning

confidence: 99%

Baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced Hypercholesterolemic rabbits

et al. 2017

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BackgroundAtherosclerosis is the most common disease of large and medium-sized arteries linked to oxidative stress, dyslipidemia as well as chronic inflammation. The aim of this study was to evaluate the potential health benefits of Baccaurea angulata (BA) fruit juice on the aorta of diet-induced hypercholesterolemic rabbits, to detect an accumulation of fatty streak and evaluate the percentage of atherosclerotic lesion accrued.MethodsThirty-five healthy male adults New Zealand White rabbits were assigned to seven different groups. Four groups were fed 1% cholesterol diet and 0, 0.5, 1.0, and 1.5 mL of BA fruit juice per kg of rabbit daily (atherogenic groups), while the other three groups were fed commercial rabbit pellet and 0, 0.5, and 1.0 mL of juice per kg of rabbit daily (normocholesterolemic groups) for 90 days. The thoracic and abdominal aorta between the heart origin and bifurcation into iliac arteries of all the rabbits were carefully removed and analyzed accordingly.ResultsThe supplementation of the high-cholesterol diet of hypercholesterolemic rabbits with only 0.5 mL BA/kg rabbit per day significantly (p < 0.001) improved aortic lipid profile, attenuated aortic fatty streak development and reduced intima thickening. Higher BA doses used (1.0 and 1.5 mL/kg rabbit per day) also significantly (p < 0.001) decreased further the development of aortic fatty streaks, reduced the thickening of the tunica intima layer and preserved endothelial healing following arterial injury.ConclusionTherefore, BA fruit is a potential novel functional food with effective anti-inflammatory, anti-atherogenic and hypocholesterolemic activities.

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“…The flavonoids from this and other species have also been shown to have anti-inflammatory [5], anti-oxidative [7], hemostatic [8], anti-hypertensive [9], antihypercholesterolemic [10] and anti-atherosclerotic activities [11].…”

Section: Introductionmentioning

confidence: 95%

Molecular Mechanism of Action for the Geranyl Flavonoid to Counter Dyslipidemia in Diabetic Milieu

Niu¹,

Li²,

Ma³

et al. 2015

JFNR

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This work was to examine the effect of 3'-methyl-4', 7-dihydroxyflavanone, a geranyl flavonoid (GF), on hepatocellular AMPK activity and lipid levels in HepG2 cells and diabetic mice, and identify molecular mechanism of the GF action on remedying dyslipidemia. The AMPK activation and lipid-lowering effect of the GF in diabetic mice and in HepG2 cells paralleled observations. The GF activated AMPK in HepG2 cells treated with high glucose, and enhance phosphorylation of ACC1 and ACC2, two isoforms of ACC, resulting in decrease in ACC activity and hepatic lipids. As demonstrated in cells overexpressing a dominant-negative AMPK mutant, the effect of GF was shown to be mediated by the activation of AMPK. The AMPK was activated relatively rapidly by GF and well before any potential change in adenosine triphosphate (ATP) level was detected. Thus, both in vivo and in vitro inhibition of AMPK, activation of ACC, and hepatocellular lipid accumulation caused by sustained high glucose levels was effectively counteracted by activating AMPK with treatment of GF. It can be conclude that GF lower lipids both in vivo and in vitro by activating AMPK and inactivating ACC, and consequently down-regulating fatty acid synthesis. The work provides a strong evidence for GF as a new therapeutic agent to definitively remedy dyslipidemia in diabetic milieu.

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Effects of Methanol Extract of Breadfruit (Artocarpus altilis) on Atherogenic Indices and Redox Status of Cellular System of Hypercholesterolemic Male Rats

Cited by 17 publications

References 46 publications

Biochemical and Histological Evaluation of Three Selected Medicinal Plant Extracts of Sri Lankan Origin on Dyslipidemia and Oxidative Stress in Alloxan Induced Diabetic Rats

Biochemical and Histological Evaluation of Three Selected Medicinal Plant Extracts of Sri Lankan Origin on Dyslipidemia and Oxidative Stress in Alloxan Induced Diabetic Rats

Baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced Hypercholesterolemic rabbits

Molecular Mechanism of Action for the Geranyl Flavonoid to Counter Dyslipidemia in Diabetic Milieu

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