Baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced Hypercholesterolemic rabbits

Abstract

BackgroundAtherosclerosis is the most common disease of large and medium-sized arteries linked to oxidative stress, dyslipidemia as well as chronic inflammation. The aim of this study was to evaluate the potential health benefits of Baccaurea angulata (BA) fruit juice on the aorta of diet-induced hypercholesterolemic rabbits, to detect an accumulation of fatty streak and evaluate the percentage of atherosclerotic lesion accrued.MethodsThirty-five healthy male adults New Zealand White rabbits were assigned to seven different groups. Four groups were fed 1% cholesterol diet and 0, 0.5, 1.0, and 1.5 mL of BA fruit juice per kg of rabbit daily (atherogenic groups), while the other three groups were fed commercial rabbit pellet and 0, 0.5, and 1.0 mL of juice per kg of rabbit daily (normocholesterolemic groups) for 90 days. The thoracic and abdominal aorta between the heart origin and bifurcation into iliac arteries of all the rabbits were carefully removed and analyzed accordingly.ResultsThe supplementation of the high-cholesterol diet of hypercholesterolemic rabbits with only 0.5 mL BA/kg rabbit per day significantly (p < 0.001) improved aortic lipid profile, attenuated aortic fatty streak development and reduced intima thickening. Higher BA doses used (1.0 and 1.5 mL/kg rabbit per day) also significantly (p < 0.001) decreased further the development of aortic fatty streaks, reduced the thickening of the tunica intima layer and preserved endothelial healing following arterial injury.ConclusionTherefore, BA fruit is a potential novel functional food with effective anti-inflammatory, anti-atherogenic and hypocholesterolemic activities.

Trihoney ameliorates hypercholesterolemia-induced epididymal histopathological changes in male rabbits

“…One percent cholesterol diet was chosen and prepared according to the methods of Ibrahim et al (2017) and Jorge et al (2005) with some modifications. Ten grams of cholesterol powder (Nacalai-Tesque, Japan) were emulsified in 20 mL (2%) of cholesterol-free extra virgin coconut oil (Certified Organic, Philippines).…”

Prolonged High-Fat Diet Feeding of WHHLMI Rabbits does Not Aggravate Metabolic or Cardiac Dysfunction

“…The reason why the HFD did not accelerate atherogenesis and subsequent development of MI might be multifactorial. To stimulate atherogenesis, experimental diets enriched in cholesterol are used [15][16][17] . Our 57T4 diet was enriched with 32 ppm (or 0.003%) cholesterol, while the SFD (5322 diet) was devoid of cholesterol.…”

“…Our 57T4 diet was enriched with 32 ppm (or 0.003%) cholesterol, while the SFD (5322 diet) was devoid of cholesterol. Most atherogenic diets are enriched with 0.015 % up to 2% cholesterol [15][16][17] and therefore the lower amount of cholesterol in our diet may partially explain the lack of atheroma progression. Exposing rabbits for one year to a HFD would expected to be long enough to aggravate atherogenesis in a model of familial hypercholesterolemia.…”

Cumin (Cuminum cyminum L.): A review of its ethnopharmacology, phytochemistry

“…The usage of herbal and other natural products for disease management, whether for prevention or treatment, has been known for ages [1][2][3][4][5] . Some edible herbal plant species, such as cumin (Cuminum cyminum L.), are also commonly used as food additives owing to their accessibility, safety, and usefulness 6 .…”