Effects of Menstrual Cycle on Cardiac Autonomic Innervation As Assessed By Heart Rate Variability

Yildirir, Aylin; Kabakçı, Giray; Akgül, Ebru; Tokgözoğlu, Lâle; Oto, Ali̇

doi:10.1111/j.1542-474x.2001.tb00140.x

Cited by 125 publications

(57 citation statements)

References 6 publications

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“…The increase in the HF spectral power instigated a signiWcant diminution of the LF/HF ratio, indicating that the balance of the autonomic system was shifted toward the parasympathetic arm. We can thus corroborate other studies that showed similar eVect of enhanced vagal modulation when estrogen levels increase, although the former were conducted in women with estrogen levels within the normal physiological range (Sato et al 1995;Yildirir et al 2001;Yildirir et al 2002;Leicht et al 2003;Princi et al 2005). The HF spectral band is traditionally associated with respiratory sinus arrhythmia, and the increase we documented in women at peak estrogen may be intuitively linked to altered respiratory function.…”

Section: Discussionsupporting

confidence: 89%

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Modulation of heart rate variability by estrogen in young women undergoing induction of ovulation

et al. 2008

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Estrogens are involved in the modulation of the cardiovascular system, yet their effects in young women remains largely unknown. Women who undergo ovulation induction treatments attain extremely high estrogen concentrations during a very short time period. The aim of the present study was to evaluate the effects of an acute increase in estrogens on the autonomic nervous system modulation of heart rate variability (HRV). A total of 27 women undergoing ovulation induction and 14 normally menstruating women were prospectively studied. HRV was assessed during nadir and peak estrogen using time domain and power spectral density analyses. A significant increase in high-frequency spectral power (243 +/- 77 vs. 188 +/- 73 ms(2)/Hz, P < 0.01) with a significant decrease in the ratio of low to high-frequency power was observed during estrogen peak in women undergoing induction of ovulation. The acute increase in estrogen in women undergoing ovulation induction was associated with vagal activation and altered sympathovagal balance.

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Section: Discussionsupporting

confidence: 89%

“…In women, modulation of HRV has been linked to Xuctuations in sex hormones (Sato et al 1995;Mercuro et al 2000;Yildirir et al 2001;Yildirir et al 2002;Leicht et al 2003;Rosa Brito-Zurita et al 2003;Princi et al 2005). However, the magnitude and direction of these eVects are as yet, controversial.…”

Section: Discussionmentioning

confidence: 96%

Modulation of heart rate variability by estrogen in young women undergoing induction of ovulation

et al. 2008

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“…Consequently, the LF-to-HF (LF/HF) ratio represents the sympathovagal balance [25]. In previous studies, HF was lower in the luteal phase than the follicular phase [26–31], and LF/HF was higher in the luteal phase than the follicular phase [26–29, 32], indicating increased sympathetic nervous activity in the luteal phase and increased parasympathetic nervous activity in the follicular phase. Moreover, sympathetic nervous activity is stronger in women with severe menstrual symptoms than in those with less severe symptoms [33].…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular response to short-term fasting in menstrual phases in young women: an observational study

Okita

Kouda

Mase³

et al. 2015

BMC Women's Health

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BackgroundMenstrual cycle-related symptoms are an important health issue for many women, and some may affect cardiac autonomic regulation. In the present study, we evaluated the cardiovascular and physiological stress response to 12-h short-term fasting in the menstrual phases of healthy young women.MethodsWe performed a randomized crossover study. Subjects were seven female university students (age: 22.3 ± 1.0 years). The experiments comprised four sessions: meal intake in the follicular phase, meal intake in the luteal phase, fasting in the follicular phase, and fasting in the luteal phase. All subjects participated in a total of four experimental sessions during two successive phases (follicular and luteal phase in the same menstrual cycle, or luteal phase and follicular phase in the next menstrual cycle) according to a randomized crossover design. R-R intervals were continuously recorded before and after meals, and power spectral analysis of heart rate variability was performed. Other physiological data were obtained before and 20, 40, 60, and 80 min after meal intake or after the corresponding time point of meal intake (fasting in the follicular or luteal phase).ResultsHeart rate decreased during fasting in the follicular and luteal phases. High frequency power increased during fasting in the follicular and luteal phases. In addition, salivary cortisol concentrations decreased during fasting in the luteal phase.ConclusionsIn the present study, short-term fasting resulted in higher parasympathetic activity and lower cortisol levels in the luteal phase in these young women. These results indicate a possibility to produce an anti-stress effect in the luteal phase, which may reduce menstrual symptoms.

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“…The study was conducted during the follicular phase of the menstrual cycle in control subjects to allow uniform influence of ovarian hormones on AFT 14 . In the study group, the test was conducted during amenorrheic period 7 .…”

Section: Methodsmentioning

confidence: 99%

Assessment of Cardiovascular Autonomic Reactivity in Patients With Polycystic Ovary Syndrome

Kuppusamy¹,

Pal²,

Habeebullah³

et al. 2014

J Biol Sci Opin

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Polycystic ovary syndrome (PCOS) in association with obesity poses a significant cardiovascular risk.Autonomic dysfunction is an early marker of cardiovascular risk. The conventional autonomic function tests (CAFT) are standard noninvasive methods of evaluating cardiovascular autonomic re activities.The study was conducted to assess the autonomic reactivity in patients with PCOS using CAFT. Forty newly diagnosed patients with PCOS and 36 age-matched controls were recruited. Body mass index (BMI), waist-hip ratio (WHR), cardiovascular parameters such as basal heart rate (BHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and rate-pressure product (RPP), were measured in them. CAFT assessed were HR and BP response to standing (30:15 ratio), deep breathing (E:I ratio) and isometric handgrip (ΔDBPihg). Association of CAFT reactivity parameters with RPP was assessed by Pearson correlation. Individual association of CAFT reactivity parameters to RPP was assessed by multiple regression analysis. The cases had significantly increased BMI, WHR, BHR, SBP, DBP, MAP and RPP. E:I ratio was decreased and 30:15 ratio and ΔDBPihg were increased in cases.30:15 ratio and ∆DBPihg had a significant positive correlation with RPP and E:I ratio showed negative correlation. Multiple regression analysis demonstrated independent association of RPP with E:I ratio and ∆DBPihg. We conclude that PCOS patients have altered autonomic modulation in the form of increased sympathetic and decreased parasympathetic reactivity. The autonomic dysregulation is linked to myocardial performance in PCOS, which could expose PCOS patients to cardiovascular morbidities.

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Effects of Menstrual Cycle on Cardiac Autonomic Innervation As Assessed By Heart Rate Variability

Abstract: We concluded that regulation of autonomic tone is modified during menstrual cycle. The alteration in the balance of ovarian hormones might be responsible for these changes in the cardiac autonomic innervation.

Cited by 125 publications

References 6 publications

Modulation of heart rate variability by estrogen in young women undergoing induction of ovulation

Modulation of heart rate variability by estrogen in young women undergoing induction of ovulation

Cardiovascular response to short-term fasting in menstrual phases in young women: an observational study

Assessment of Cardiovascular Autonomic Reactivity in Patients With Polycystic Ovary Syndrome

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