Modulation of heart rate variability by estrogen in young women undergoing induction of ovulation

Weissman, Amir; Löwenstein, Lior; Tal, J.; Ohel, Gonen; Calderon, Ilan; Lightman, Abraham

doi:10.1007/s00421-008-0914-4

Cited by 23 publications

(23 citation statements)

References 23 publications

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“…To date, only seven studies (of roughly 49 currently available studies on cardiac vagal activity across the menstrual cycle as suggested by our meta-analysis [28] and a recent review [30]) have reported associations between ovarian hormone levels and cardiac vagal activity, with mixed results [27,[31][32][33][34][35][36]. However, four major methodological and statistical limitations in these studies prevent clear conclusions.…”

Section: Introductionmentioning

confidence: 80%

Menstrual Cycle Changes in Vagally-Mediated Heart Rate Variability Are Associated with Progesterone: Evidence from Two Within-Person Studies

Schmalenberger

Eisenlohr‐Moul

Jarczok

et al. 2020

JCM

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A recent meta-analysis revealed that cardiac vagal activity (mostly indicated by vagally-mediated heart rate variability; HRV) decreases significantly from the follicular to luteal menstrual cycle phase in naturally-cycling participants. However, the question remains as to whether cyclical changes in estradiol (E2), progesterone (P4), or both are responsible for HRV fluctuations. We present the first studies to use repeated measures of E2, P4, and HRV across the cycle to model both the unique and interactive effects of person-centered E2 and P4 on HRV in multilevel models. In study one, 40 naturally-cycling participants were assessed weekly across four weeks, and were blind to the cycle focus of the study. In study two, 50 naturally-cycling participants were examined in three precisely defined cycle phases via ovulation testing. Both studies revealed that only P4 was correlated with HRV, such that higher-than-usual P4 significantly predicted lower-than-usual HRV within a given participant. In line with this, cycle phase comparisons revealed lower HRV in the mid-luteal phase (characterized by elevated P4) than in other phases. No significant main or interactive effects of E2 on HRV were found. Future female health studies should investigate individual differences in these effects and potential consequences of cyclical HRV changes on daily functioning.

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Section: Introductionmentioning

confidence: 80%

Menstrual Cycle Changes in Vagally-Mediated Heart Rate Variability Are Associated with Progesterone: Evidence from Two Within-Person Studies

Schmalenberger

Eisenlohr‐Moul

Jarczok

et al. 2020

JCM

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“…Postmenopausal women taking estrogen replacement therapy have higher HF power than postmenopausal women not taking estrogen (Liu et al, 2003). Also, women have reduced HF power following oophorectomy that is restored to pre-surgical values with estrogen therapy (Mercuro et al, 2000) and women undergoing acute estrogen treatment for ovulation induction have increased HF power compared to before treatment (Weissman et al, 2009). There is less evidence for the influence of progesterone on the autonomic nervous system.…”

Section: Discussionmentioning

confidence: 99%

Autonomic regulation across phases of the menstrual cycle and sleep stages in women with premenstrual syndrome and healthy controls

Zambotti

Nicholas

Colrain

et al. 2013

Psychoneuroendocrinology

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Summary To investigate the influence of menstrual cycle phase and the presence of severe premenstrual symptoms on cardiac autonomic control during sleep, we performed heart rate variability (HRV) analysis during stable non-rapid eye movement (NREM) and REM sleep in 12 women with severe premenstrual syndrome and 14 controls in the mid-follicular, mid-luteal, and late-luteal phases of the menstrual cycle. Heart rate was higher, along with lower high frequency (HF) power, reflecting reduced vagal activity, and a higher ratio of low frequency (LF) to high frequency power, reflecting a shift to sympathetic dominance, in REM sleep compared with NREM sleep in both groups of women. Both groups of women had higher heart rate during NREM and REM sleep in the luteal phase recordings compared with the mid-follicular phase. HF power in REM sleep was lowest in the mid-luteal phase, when progesterone was highest, in both groups of women. The mid-luteal phase reduction in HF power was also evident in NREM sleep in control women but not in women with PMS, suggesting some impact of premenstrual syndrome on autonomic responses to the hormone environment of the mid-luteal phase. In addition, mid-luteal phase progesterone levels correlated with HF power and LF/HF ratio in control women in NREM sleep and with the LF/HF ratio during REM sleep in both groups of women. Our findings suggest the involvement of female reproductive steroids in cardiac autonomic control during sleep in women with and without premenstrual syndrome.

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“…Both age-related changes as well as gender differences of R-R interval dynamics are likely linked to (pre-) pubertal hormonal changes [17] because hormones such as estrogen and progesterone as well as substantial changes of hormonal levels during induction of ovulation, onset of menopause or estrogen replacement therapy have been associated with alterations of R-R interval dynamics [32]–[34]. The present results with respect to long-term fractal scaling properties and complexity suggest that pre-puberty and adrenarche (age 7 to 9 years) also have a specific impact on R-R interval dynamics.…”

Section: Discussionmentioning

confidence: 99%

Unexpected Course of Nonlinear Cardiac Interbeat Interval Dynamics during Childhood and Adolescence

et al. 2011

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The fluctuations of the cardiac interbeat series contain rich information because they reflect variations of other functions on different time scales (e.g., respiration or blood pressure control). Nonlinear measures such as complexity and fractal scaling properties derived from 24 h heart rate dynamics of healthy subjects vary from childhood to old age. In this study, the age-related variations during childhood and adolescence were addressed. In particular, the cardiac interbeat interval series was quantified with respect to complexity and fractal scaling properties. The R-R interval series of 409 healthy children and adolescents (age range: 1 to 22 years, 220 females) was analyzed with respect to complexity (Approximate Entropy, ApEn) and fractal scaling properties on three time scales: long-term (slope β of the power spectrum, log power vs. log frequency, in the frequency range 10−4 to 10−2 Hz) intermediate-term (DFA, detrended fluctuation analysis, α2) and short-term (DFA α1). Unexpectedly, during age 7 to 13 years β and ApEn were higher compared to the age <7 years and age >13 years (β: −1.06 vs. −1.21; ApEn: 0.88 vs. 0.74). Hence, the heart rate dynamics were closer to a 1/f power law and most complex between 7 and 13 years. However, DFA α1 and α2 increased with progressing age similar to measures reflecting linear properties. In conclusion, the course of long-term fractal scaling properties and complexity of heart rate dynamics during childhood and adolescence indicates that these measures reflect complex changes possibly linked to hormonal changes during pre-puberty and puberty.

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Modulation of heart rate variability by estrogen in young women undergoing induction of ovulation

Cited by 23 publications

References 23 publications

Menstrual Cycle Changes in Vagally-Mediated Heart Rate Variability Are Associated with Progesterone: Evidence from Two Within-Person Studies

Menstrual Cycle Changes in Vagally-Mediated Heart Rate Variability Are Associated with Progesterone: Evidence from Two Within-Person Studies

Autonomic regulation across phases of the menstrual cycle and sleep stages in women with premenstrual syndrome and healthy controls

Unexpected Course of Nonlinear Cardiac Interbeat Interval Dynamics during Childhood and Adolescence

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