2005
DOI: 10.1016/j.yjmcc.2005.03.017
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Effects of menadione and its derivative on cultured cardiomyocytes with mitochondrial disorders

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Cited by 23 publications
(12 citation statements)
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“…Our data complements studies from other labs showing that MB and VK potentiate mitochondrial energy production by acting as alternative electron carriers (Wen et al, 2011, Vos et al, 2012, Shneyvays et al, 2005). VK3, MB and NQN1 did not increase ECAR (Figure 4D), suggesting that the elevated ATP levels we measured (Figure 5) are indeed due to increased mitochondrial oxidative phosphorylation, and not glycolysis.…”
Section: Discussionsupporting
confidence: 90%
“…Our data complements studies from other labs showing that MB and VK potentiate mitochondrial energy production by acting as alternative electron carriers (Wen et al, 2011, Vos et al, 2012, Shneyvays et al, 2005). VK3, MB and NQN1 did not increase ECAR (Figure 4D), suggesting that the elevated ATP levels we measured (Figure 5) are indeed due to increased mitochondrial oxidative phosphorylation, and not glycolysis.…”
Section: Discussionsupporting
confidence: 90%
“…Accordingly, in yeast except of menadione no other quinone was able to bridge the electron transfer of NADH oxidation when complex III was inhibited (Nosoh et al ., ; Brivet‐Chevillotte and di Rago, ). Likewise, menadione restored the electron flow and ATP formation in cardiomyocytes after the inhibition of complex I with rotenone (Shneyvays et al ., ).…”
Section: Discussionmentioning
confidence: 97%
“…Addition of menadione (MEN, Vitamin K 3 ), can stimulate electron transfer within the inner membranes of the mitochondria, 42 which can produce a significant and rapid increase in Fp and decrease in NAD(P)H fluorescence intensity respectively (Figs. 4 and 5).…”
Section: Resultsmentioning
confidence: 99%