Effects of Melissa officinalis L. on Reducing Stress, Alleviating Anxiety Disorders, Depression, and Insomnia, and Increasing Total Antioxidants in Burn Patients

Chehroudi, Shirin; Fatemi, Mohammad Javad; Isfeedvajani, Mohsen Saberi; Salehi, Seyed Hamid; Akbari, Hossein; Samimi, Roghayeh

doi:10.5812/traumamon.33630

Cited by 12 publications

(19 citation statements)

References 40 publications

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“…Sleep quality in Melissa officinalis treated increased significantly. However, the mean serum antioxidant levels were not significantly changed by Melissa officinalis [81].…”

Section: Melissa Officinalismentioning

confidence: 77%

A complementary and alternative natural antidepressant therapy with emphasis on their mechanisms of action

Al-Snafi¹

2021

Int. J. Biol. Pharm. Sci. Arch.

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Medicinal plants can exert antidepressant activity by many mechanisms included neutralization of various stress mediators (regulate the activity of the hypothalamic- pituitary- adrenal axis and reduce CRF, and ACTH and corticosterone) [5], interaction with serotonergic systems (5-HT3, 5HT2A, 5-HT1A), noradrenergic (α1 and α2 receptors) and dopaminergic (D1 and D2) receptors [6],restoring monoamine transmitters and their receptors to normal limits in certain regions of the cortex, in addition to reducing of oxidative stress and amelioration of inflammatory mediators. The current review discussed the antidepressant activity of medicinal plants, with emphasis on their mechanisms of action.

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“…Sleep quality in Melissa officinalis treated increased significantly. However, the mean serum antioxidant levels were not significantly changed by Melissa officinalis [81].…”

Section: Melissa Officinalismentioning

confidence: 77%

A complementary and alternative natural antidepressant therapy with emphasis on their mechanisms of action

Al-Snafi¹

2021

Int. J. Biol. Pharm. Sci. Arch.

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“…Herbs are a source of safe phytochemicals with a beneficial effect on CNS disorders [168]. The prophylaxis and adjuvant treatment of depression are based on raw materials from many plant species e.g., representatives of the genera Aloysia [170], Crocus [171][172][173][174][175], Gladiolus [176][177][178], Hemerocallis [179,180], Hypericum [181][182][183][184], Lavandula [185][186][187], Melisa [188][189][190], and Valeriana [191][192][193]. The observations described in this paper fit in the search for new antidepressants based on the pathogenetic mechanisms of depression summed up in a review by Ates-Alagoz et al [135] and Kalkman [51].…”

Section: Phytotherapymentioning

confidence: 99%

Recent Studies on Anti-Depressant Bioactive Substances in Selected Species from the Genera Hemerocallis and Gladiolus: A Systematic Review

et al. 2019

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Herbal therapy is a potential alternative applied to pharmacological alleviation of depression symptoms and treatment of this disorder, which is predicted by the World Health Organization (WHO) to be the most serious health problem worldwide over the next several years. It has been well documented that many herbs with psychotropic effects have far fewer side effects than a variety of pharmaceutical agents used by psychiatrists for the treatment of depression. This systematic review presents literature data on the antidepressant activity of representatives of the genera Hemerocallis (H. fulva and H. citrina Baroni, family Xanthorrhoeaceae) and Gladiolus (G. dalenii, family Iridaceae) and on biologically active compounds and their mechanisms of action to consider the application of herbal preparations supporting the treatment of depression.

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“…Therapeutic effects of M. officinalis include improving mood, reducing anxiety, increasing the level of anti-oxidants in the body, anti-tumor and anti-bacterial activities (21). M. officinalis contains large amounts of Rosmarinic acid, flavonoids and terpenoids, and its analgesic effects are attributed to these substances (22). It is reported that oral prescription of M. officinalis for up to eight weeks is well tolerated (23).…”

Section: Introductionmentioning

confidence: 99%

Evaluating the effect of Matricaria chamomilla and Melissa officinalis on pain intensity and satisfaction with pain management in patients after orthopedic surgery

Saidi

Heidari

Sedehi

et al. 2020

J Herbmed Pharmacol

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Introduction: The most important compliant of post-operative orthopedic patients is severe and intolerable pain. This pain has negative impacts on patient’s satisfaction with pain management and bone healing after surgery. This study was conducted with the aim of evaluating the effects of Melissa officinalis (Melissa) tea and Matricaria chamomilla (Chamomile) tea on pain intensity and satisfaction with pain management in patients after lower limb orthopedic surgery. Methods: This was a randomized controlled trial conducted on 96 patients after lower limb orthopedic surgery in Ayatollah Kashani hospital of Shahrekord city, Iran. Patients were randomized to M. officinalis, Chamomile and control groups with blocking randomization method. For M. officinalis group, 1 g of Melissa tea, for Chamomile group 1 g chamomile tea and for control group black tea was prescribed 3 times a day. Study variables were evaluated before and 30 min after each stage of intervention and then the mean changes of pain intensity and satisfaction before interventions and after each step of intervention were compared between groups. Significance level was considered as P<0.05. Results: Before intervention, the mean scores of pain intensity and satisfaction with pain management had no significance difference between groups. The mean changes of pain intensity and satisfaction with pain management (after first 3 steps of intervention) in M. officinalis and M. chamomilla groups were significantly greater than the ones in control group (P<0.05). Conclusion: Prescription of M. officinalis tea or Chamomile tea might be used as effective remedy for reducing pain and increasing satisfaction with pain management after orthopedic surgery.

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Effects of Melissa officinalis L. on Reducing Stress, Alleviating Anxiety Disorders, Depression, and Insomnia, and Increasing Total Antioxidants in Burn Patients

Cited by 12 publications

References 40 publications

A complementary and alternative natural antidepressant therapy with emphasis on their mechanisms of action

A complementary and alternative natural antidepressant therapy with emphasis on their mechanisms of action

Recent Studies on Anti-Depressant Bioactive Substances in Selected Species from the Genera Hemerocallis and Gladiolus: A Systematic Review

Evaluating the effect of Matricaria chamomilla and Melissa officinalis on pain intensity and satisfaction with pain management in patients after orthopedic surgery

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