Effects of melatonin on plasma oxidative stress in rats with streptozotocin induced diabetes

Klepac, Nataša; Rudeš, Zoran; R, Klepac

doi:10.1016/j.biopha.2005.08.005

Cited by 40 publications

(38 citation statements)

References 20 publications

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“…Administration of Vanadium complex at both the doses and Glimepiride significantly decreased the TBARS level compared to the diabetic control group in all the three tissues. Increased level of LPO observed in the present study in the diabetic control may be due to hyperglycemia followed by oxidative stress as suggested by Koyutruk et al,(2005), Wolff and Dean (1987), Das et al,(2000) and Klepac et al, (2005).…”

Section: Lipid Peroxidationsupporting

confidence: 66%

Antioxidant status in streptozotocin induced diabetic rats treated with vanadium complex

Kannan¹,

Vijayaraj²,

Sesh³

et al. 2016

IJAR

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As lipid peroxidation and oxidative stress play a key role in the pathogenesis of diabetes, the antioxidant status of streptozotocin induced diabetic rats, treated with vanadium complex was explored in the present study. Diabetes was induced by single intraperitoneal injection of streptozotocin (STZ) at the dose rate of 45 mg per kg body weight. Diabetes was confirmed after 72 hours of STZ injection by estimating blood glucose level and those rats showing more than 250 mg/ dL were considered as diabetic. Vanadium complex at the dose rates of 5 and 10 mg / kg body weight was administered orally to normal control and STZ induced diabetic rats. Glimepiride was used as the positive control and was given orally at the dose rate of 800 μg / Kg body weight. The study on the hepatic, renal and pancreatic tissues showed that vanadium complex at both the predetermined dosages significantly increased the antioxidant activities of superoxide dismutase and glutathione peroxidase along with a significant increase in the level of glutathione and a significant decrease in the level of lipid peroxidation. The study also revealed that there is a significant reduction in the activity of catalase after treatment with vanadium complex at both the dosage levels.

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Section: Lipid Peroxidationsupporting

confidence: 66%

Antioxidant status in streptozotocin induced diabetic rats treated with vanadium complex

Kannan¹,

Vijayaraj²,

Sesh³

et al. 2016

IJAR

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“…For example, melatonin, a hormone from the pineal gland of vertebrates, was found to be not only a strong free radical scavenger, but also a stimulator of antioxidative enzymes (Klepac et al 2006). Tutunculer et al (2005) found that melatonin could protect against brain injury by oxidative stress, and this protective effect may be due to its direct scavenging activity and activation of CAT.…”

Section: ·75 £ 10mentioning

confidence: 99%

Beneficial effect of Toona sinensis Roemor on improving cognitive performance and brain degeneration in senescence-accelerated mice

et al. 2006

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The purpose of the present study was to examine the effects of Toona sinensis Roemor extracts on antioxidative activities, brain morphological changes and cognitive ability. In an in vitro study, the antioxidant capacities of water extracts from Toona sinensis Roemor leaf (TSL), root (TSR) and bark (TSB) were evaluated by an a,a-diphenyl-b-pricryl-hydrazyl radical-scavenging test. The results showed that the scavenging activities of all Toona sinensis Roemor extracts were over 80 % at a concentration of 0·625 mg/ml. In an in vivo study, 3-month-old male senescence-accelerated-prone 8 mice were used as the tested subjects and fed four different diets: casein diet or casein diet supplemented with 1 % TSL, TSR or TSB extract for 12 weeks. The results showed that the mice supplemented with Toona sinensis Roemor extracts demonstrated significantly less amyloid b-protein deposition and lower levels of thiobarbituric acid-reactive substances than the control group. All Toona sinensis Roemor diet groups also showed better active shuttle avoidance responses, and higher superoxide dismutase, catalase and glutathione peroxidase activities, than the control group. It can thus be concluded that supplementation with either TSL, TSR or TSB extract could not only reduce the incidence of ß-amyloid plaques, but also improve learning and memory ability in senescence-accelerated-prone 8 mice. This might be due to the beneficial effects of Toona sinensis Roemor extracts on promoting the antioxidative defence system. Free radical-mediated reactions and reactive oxygen species have been proposed to be the major contributors to the pathological processes of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Alzheimer's disease is accompanied by cognitive impairment as well as involving the pathological build-up of extracellular, vascular and parenchymal deposits of a 40 -42-amino peptide, amyloid b-protein. It has been demonstrated that oxidative damage increased both in the brains of individuals with Alzheimer's disease (Friedlich & Butcher, 1994;Smith et al. 1997;Montine et al. 1999) and in b-amyloid plaque-forming transgenic mouse models of Alzheimer's disease Pappolla et al. 1998;Smith et al. 1998), suggesting that an elevated level of amyloid b-protein is sufficient to stimulate oxidative damage. In an in vitro study, a direct application amyloid b-protein to neuronal cells increased the production of H 2 O 2 (Behl et al. 1994), leading to amyloid b-protein neurotoxicity, which could be prevented by the use of antioxidants (Behl et al. 1992;Goodman et al. 1994).The development of rodent models of Alzheimer's disease will elucidate some important aspects of the aetiology of the disease and the development of therapeutic methods. In a murine model of accelerated senescence (senescence-accelerated mouse), severe senile amyloidosis is one of the most characteristic age-associated disorders (Higuchi et al. 2004). Ohta et al. (1989) and Flood & Morley (1993) have reported that the senescence-accelerated-prone 8 (SAM...

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“…s0290 4.4.2 Melatonin p1105 Indoleamine hormone melatonin, secreted by pinealocytes (Stehle et al, 2011), is a powerful free radical scavenger and lipophilic antioxidant agent (Galano et al, 2011;Reiter et al, 2002). Apart from its main biological function (regulating circadian cycle-e.g., Lanfumey et al, 2013), melatonin shows activity against oxidative stress and inflammatory and apoptotic processes in diabetic complications (Chang et al, 2008;Klepac et al, 2006;Zwirska-Korczala et al, 2005). In addition, melatonin has strong mitochondria-protective effects (Kim and Lee, 2008).…”

Section: Anti-vegf Antibodiesmentioning

confidence: 99%

Neuropeptides, Trophic Factors, and Other Substances Providing Morphofunctional and Metabolic Protection in Experimental Models of Diabetic Retinopathy

Szabadfi

Pintér

Reglődi

et al. 2014

International Review of Cell and Molecular Biology

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Effects of melatonin on plasma oxidative stress in rats with streptozotocin induced diabetes

Cited by 40 publications

References 20 publications

Antioxidant status in streptozotocin induced diabetic rats treated with vanadium complex

Antioxidant status in streptozotocin induced diabetic rats treated with vanadium complex

Beneficial effect of Toona sinensis Roemor on improving cognitive performance and brain degeneration in senescence-accelerated mice

Neuropeptides, Trophic Factors, and Other Substances Providing Morphofunctional and Metabolic Protection in Experimental Models of Diabetic Retinopathy

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