Effects of Melatonin and/or Magnesium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial

Mousavi, Reihaneh; Alizadeh, Mohammad; Jafarabadi, Mohammad Asghari; Heidari, Lida; Nikbakht, Roshan; Babaahmadi‐Rezaei, Hossein; Karandish, Majid

doi:10.1007/s12011-021-02725-y

Cited by 26 publications

(35 citation statements)

References 47 publications

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“…As shown in Figure 1 , among 2501 records initially screened, 31 were retrieved as full-texts: of them, 17 papers [ 17 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ] were included in the systematic review with 15 contributing to the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

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Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

Veronese

Pizzol²,

Smith

et al. 2022

Nutrients

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Magnesium (Mg) may have several beneficial effects on human health outcomes. One hypothesized mechanism eliciting such effects is the action of Mg on serum inflammatory parameters. However, studies on this topic to date have several important limitations. Therefore, the present systematic review and meta-analysis aimed to summarize the current state of the art of all randomized control trials (RCTs) investigating the effects of Mg supplementation versus placebo on serum parameters of inflammation. We searched several databases until 23rd November 2021 for RCTs. Eligible studies were RCTs investigating the effect of oral Mg supplementation vs. placebo and having serum inflammatory markers as an outcome. Among 2484 papers initially screened, 17 randomized controlled trials (889 participants; mean age: 46 years; females: 62.5%) were included. Generally, a low risk of bias was present. In meta-analysis, Mg supplementation significantly decreased serum C reactive protein (CRP) and increased nitric oxide (NO) levels. In descriptive findings, Mg supplementation significantly reduced plasma fibrinogen, tartrate-resistant acid phosphatase type 5, tumor necrosis factor-ligand superfamily member 13B, ST2 protein, and IL-1. In conclusion, Mg supplementation may significantly reduce different human inflammatory markers, in particular serum CRP and NO levels.

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Section: Resultsmentioning

confidence: 99%

“… Forrest plot of the effect of magnesium versus placebo on serum C-reactive protein [ 17 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 35 , 36 , 38 , 39 ]. …”

Section: Figurementioning

confidence: 99%

Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

Veronese

Pizzol²,

Smith

et al. 2022

Nutrients

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“…It should also be considered that calorie restriction can increasingly lead to muscle and fat loss and, thus, contribute to cachexia-related sarcopenia [ 40 ]. Stabilization of body weight can, thus, improve the course of therapy and prognosis of the patient in the long term [ 41 , 42 , 43 ].…”

Section: Nutrition and Nutrition Assessmentmentioning

confidence: 99%

“…Already in the last decade, as well as increasingly in the pandemic period, the interest in health-promoting nutrient preparations has grown, which makes this topic no less relevant for oncological patients. Although studies with potential benefits already exist regarding individual micronutrients and trace elements, these results are not yet meaningful enough for a recommendation [ 42 ]. It is recommended that vitamin and trace element products should be administered only if there is an indication of a deficiency condition.…”

Section: Nutrition and Nutrition Assessmentmentioning

confidence: 99%

“…It is recommended that vitamin and trace element products should be administered only if there is an indication of a deficiency condition. For all micronutrients and trace elements, the recommendations of the national societies and the guideline of the European Society for Clinical Nutrition and Metabolism (ESPEN) [ 42 , 55 ] apply to substitution. The supplementation of nutrients should only be carried out in consultation with the attending physician.…”

Section: Nutrition and Nutrition Assessmentmentioning

confidence: 99%

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Supportive Care in Oncology—From Physical Activity to Nutrition

et al. 2022

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The diagnosis and treatment of cancer are associated with impairment at the physical and at psychological level. In addition, side effects are a potentially treatment-limiting factor that may necessitate dose reduction, delay, or even discontinuation of therapy, with negative consequences for outcome and mean survival. Numerous studies have shown that physical activity and sports and exercise therapy programs are not only practicable but also recommendable for oncologic patients during the acute phase and in the aftercare. Furthermore, nutrition plays an important role in all stages of tumor therapy. A timely integration of a nutrition therapy and physical activity in the form of physiotherapy and sports therapy serves to prevent and reduce treatment-associated side effects. Evidence-based recommendations on cancer prevention through nutrition therapy, physical activity, and sports and exercise therapy should be integrated into treatment plans for oncology patients as well as in health care services for the general population. Individual counselling by trained nutrition and exercise specialists may be advisable to receive concrete recommendations on the respective tumor entity or specific side effects. This mini review is based on a selective literature search in the PubMed database and Cochrane Central Register of Controlled Trials on the subjects of healthy diet and physical activity in primary prevention and follow-up about cancer.

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Melatonin and Inflammatory and Immune-Modulated Diseases: New Applications of a Metabolite Also Produced by Plants

Laurindo,

de Oliveira Zanuso,

Guiguer

et al. 2023

Reference Series in Phytochemistry

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Effects of Melatonin and/or Magnesium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial

Cited by 26 publications

References 47 publications

Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

Supportive Care in Oncology—From Physical Activity to Nutrition

Melatonin and Inflammatory and Immune-Modulated Diseases: New Applications of a Metabolite Also Produced by Plants

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