Effects of melatonin administration to cashmere goats on cashmere production and hair follicle characteristics in two consecutive cashmere growth cycles

Yang, Ching Hong; Duan, Chunhui; Wu, Ziyuan; Yan, Li; Luan, Yinyin; Fu, Xiajie; Zhang, Chunxiang; Zhang, Wei

doi:10.1016/j.domaniend.2020.106534

Cited by 16 publications

(19 citation statements)

References 19 publications

(31 reference statements)

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“…Therefore, it is speculated that the stimulation of exogenous MT may change the growth cycle of Inner Mongolia cashmere goat hair follicles in the early flourishing period, but it has no obvious effect on the stage from the growth period to the beginning of the next cashmere growth cycle. This finding is consistent with previous studies on the effect of MT on cashmere performance of Inner Mongolia alba cashmere goats (Yang et al, 2020). However, we want to know why the effect of MT implantation on hair follicle growth of cashmere goats is weakened after the growth period, which provides a new direction and idea for future research on MT.…”

Section: Mt Affects Cashmere Growth In Cashmere Goatssupporting

confidence: 90%

“…The data also indicated that the levels of MT in plasma vary greatly among different individuals at night. By implanting MT in Inner Mongolia cashmere goats, Yang found that the serum MT concentration in the treatment group was significantly higher than that in the control group, which was consistent with the experimental result of our study (Yang et al, 2020).…”

Section: Mt Concentration In Plasma Of Cashmere Goats In the Implanted Group And Control Groupsupporting

confidence: 89%

“…Z., 2020;Yang C. H., 2020). According to previous studies, two MT implants during the non-fleece period can improve the cashmere yields of Inner Mongolia cashmere goats to different degrees (Yang et al, 2020). Genes play a decisive role in the process of cashmere growth.…”

Section: Introductionmentioning

confidence: 99%

“…MT is found in the pineal gland and various other tissues and organs of vertebrates, including multifunctional molecules synthesized by the retina (Zawilska et al, 1995), bone marrow (Tan et al, 1999), gastrointestinal tract (Lepage et al, 2005), placenta (Lanoix et al, 2008), testis (Ji et al, 2012), and ovary (Tamura et al, 2017). Among its various physiological functions, MT exerts its powerful antioxidant capacity by directly scavenging free radicals and stimulating the activity of antioxidant enzymes (Reiter et al, 2017;Yang et al, 2020). In a study on the effects of light and MT implantation on cashmere production performance and regulation in Inner Mongolia white cashmere goats, periodic changes in light made the norepinephrine content periodic through the sympathetic nervous system, thus making the amount of 5-hydroxytryptamine (5-ht) and MT periodic (Tan et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Melatonin Regulates the Periodic Growth of Cashmere by Upregulating the Expression of Wnt10b and β-catenin in Inner Mongolia Cashmere Goats

Liu

et al. 2021

Front. Genet.

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Secondary hair follicle growth in cashmere goats has seasonal cycle changes, and melatonin (MT) has a regulatory effect on the cashmere growth cycle. In this study, the growth length of cashmere was measured by implanting MT in live cashmere goats. The results indicated that the continuous implantation of MT promoted cashmere to enter the anagen 2 months earlier and induce secondary hair follicle development. HE staining of skin tissues showed that the number of secondary hair follicles in the MT-implanted goats was significantly higher than that in the control goats (P < 0.05). Transcriptome sequencing of the skin tissue of cashmere goats was used to identify differentially expressed genes: 532 in February, 641 in October, and 305 in December. Fluorescence quantitative PCR and Western blotting results showed that MT had a significant effect on the expression of Wnt10b, β-catenin, and proteins in the skin tissue of Inner Mongolia cashmere goats. This finding suggested that MT alters the cycle of secondary hair follicle development by changing the expression of related genes. This research lays the foundation for further study on the mechanism by which MT regulates cashmere growth.

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Section: Mt Affects Cashmere Growth In Cashmere Goatssupporting

confidence: 90%

Section: Mt Concentration In Plasma Of Cashmere Goats In the Implanted Group And Control Groupsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Melatonin Regulates the Periodic Growth of Cashmere by Upregulating the Expression of Wnt10b and β-catenin in Inner Mongolia Cashmere Goats

Liu

et al. 2021

Front. Genet.

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“…Previous studies have shown that the use of exogenous melatonin could stimulate cashmere growth during the resting period. However, the implanting time and duration of melatonin could result in earlier cashmere shedding followed by another typical cycle of cashmere growth [6][7][8][9], or increase cashmere yield by combining the induced growth of cashmere fleece [10,11]. It has been confirmed that exogenous melatonin has a positive role on cashmere growth.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Dynamics Reveal Stage-specific and Melatonin-triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

Cong

et al. 2021

Preprint

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Background: Cashmere goat is famous for its high-quality fibers. The growth of cashmere in secondary hair follicles exhibits a seasonal pattern arising from circannual changes in the natural photoperiod. Although several studies have compared and analyzed the differences in gene expression between different cashmere growth stages, the selection of samples in these studies relies on research experience or morphological evidence. Distinguishing cashmere growth cycles according to gene expression patterns may help to explore the regulation mechanisms related to cashmere growth and the effect of melatonin from a molecular level more accurately. Results: In this study, we applied RNA-sequencing to the hair follicles of three normal and three melatonin-treated Inner Mongolian cashmere goats sampled every month during a whole cashmere growth cycle. A total of 3559 and 988 genes were subjected as seasonal changing genes (SCGs) in the control and treated groups, respectively. The SCGs in the normal group are divided into three clusters, and their specific expression patterns help to group the cashmere growth cycle into anagen, catagen and telogen stages. Some canonical pathways such as Wnt, TGF-beta and Hippo signaling pathways are detected as promoting the cashmere growth, while Cell adhesion molecules (CAMs), Cytokine-cytokine receptor interaction, Jak-STAT, Fc epsilon RI, NOD-like receptor, Rap1, PI3K-Akt, cAMP, NF-kappa B and many immune-related pathways are detected in the catagen and telogen stages. The PI3K-Akt signaling, ECM-receptor interaction and Focal adhesion are found in the transition stage between telogen to anagen, which may serve as candidate biomarkers for telogen-anagen regeneration. Pairwise comparisons between the control and melatonin-treated groups also indicate 941 monthly differentially expressed genes (monthly DEGs). These monthly DEGs are mainly distributed from April and September, which reveal a potential signal pathway map regulating the anagen stage triggered by melatonin. Enrichment analysis shows that Wnt, Hedgehog, ECM, Chemokines and NF-kappa B signaling pathways may be involved in the regulation of non-quiescence and secondary shedding under the influence of melatonin. Conclusions: Our study decodes the key regulators of the whole cashmere growth cycle, laying the foundation for the control of cashmere growth and improvement of cashmere yield.

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Inhibition of prolactin promotes secondary skin follicle activation in cashmere goats

Zhang

Duan

Guo

et al. 2021

Journal of Animal Science

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The aim of this study was to investigate the involvement of prolactin (PRL) on development of secondary skin follicles in cashmere goats. Goats were randomly assigned to either a bromocriptine treatment or control group. Samples of cashmere fiber, blood and skin were collected from all goats after 1 month. The results indicated that the length, growth rate and diameter of fibers were not influenced (P > 0.05) by the inhibition of prolactin resulting from the treatment with bromocriptine. There was a tendency for increases in total follicle number, primary and secondary follicle numbers and in the ratio of secondary to primary follicles following treatment with bromocriptine, but these differences were not significant (P > 0.05). The percentage of active secondary follicles in anagen was increased (P < 0.05) in the bromocriptine-treated goats but there was no effect of treatment on the percentage of active primary follicles. Bromocriptine decreased (P < 0.05) circulating concentrations of PRL and Insulin-like growth factor 1 (IGF1) and increased (P < 0.05) those of melatonin (MT), but there was no effect of this treatment on the serum concentrations of cortisol (COR), growth hormone (GH), tetraiodothyronine (T4) and triiodothyronine (T3). In bromocriptine-treated goats mRNA expressions of PRL and MT membrane receptor 1a (MTNR1a) were decreased (P < 0.05) and mRNA expression of MT nuclear receptor (RORα) was increased (P < 0.05), but there was no effect of the treatment on expression of long PRL receptor (LPRLR), short PRL receptor (SPRLR), MT membrane receptor 1b (MTNR1b) and IGF1. It is concluded that inhibition of PRL promotes secondary hair follicle development in the anagen phase, possibly by down-regulating MTNR1a and up-regulating RORα gene expression in the skin.

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Effects of melatonin administration to cashmere goats on cashmere production and hair follicle characteristics in two consecutive cashmere growth cycles

Cited by 16 publications

References 19 publications

Melatonin Regulates the Periodic Growth of Cashmere by Upregulating the Expression of Wnt10b and β-catenin in Inner Mongolia Cashmere Goats

Melatonin Regulates the Periodic Growth of Cashmere by Upregulating the Expression of Wnt10b and β-catenin in Inner Mongolia Cashmere Goats

Transcriptome Dynamics Reveal Stage-specific and Melatonin-triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

Inhibition of prolactin promotes secondary skin follicle activation in cashmere goats

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