Inhibition of prolactin promotes secondary skin follicle activation in cashmere goats

Zhang, Lechao; Duan, Chunhui; Guo, Yunxia; Zhang, Yingjie; Liu, Yueqin

doi:10.1093/jas/skab079

Cited by 10 publications

(10 citation statements)

References 53 publications

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“…The cashmere quality at 1 year old is the highest among all age groups, and with the increase in age, the cashmere quality had a decreasing trend. Some reports show that low energy and protein levels can improve the fineness and length of cashmere, trace elements can improve the strength of cashmere fiber, and the change in blood hormone levels will affect the character of cashmere [ 34 , 35 ]. The quality is highest in 1/2-year-old goats and thereafter declines with the increasing age of the animals [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFκB and AP-1

Diao

Duan

Yao

et al. 2023

IJMS

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Exogenous melatonin (MT) has been used to promote the growth of secondary hair follicles and improve cashmere fiber quality, but the specific cellular-level mechanisms involved are unclear. This study was carried out to investigate the effect of MT on the development of secondary hair follicles and on cashmere fiber quality in cashmere goats. The results showed that MT improved secondary follicle numbers and function as well as enhanced cashmere fiber quality and yield. The MT-treated goat groups had high secondary-to-primary ratios (S:P) for hair follicles, greater in the elderly group (p < 0.05). Antioxidant capacities of secondary hair follicles improved fiber quality and yield in comparison with control groups (p < 0.05/0.01). Levels of reactive oxygen and nitrogen species (ROS, RNS) and malondialdehyde (MDA) were lowered (p < 0.05/0.01) by MT. There was significant upregulation of antioxidant genes (for SOD-3; GPX-1; NFE2L2) and the protein of nuclear factor (Nrf2), and downregulation of the Keap1 protein. There were significant differences in the expression of genes for secretory senescence-associated phenotype (SASP) cytokines (IL-1β, IL-6, MMP-9, MMP-27, CCL-21, CXCL-12, CXCL-14, TIMP-1,2,3) plus their protein of key transcription factors, nuclear factor kappa B (NFκB) and activator protein-1 (AP-1), in comparison with the controls. We concluded that MT could enhance antioxidant capacity and reduce ROS and RNS levels of secondary hair follicles through the Keap1-Nrf2 pathway in adult cashmere goats. Furthermore, MT reduced the expression of the SASP cytokines genes by inhibiting the protein of NFκB and AP-1 in the secondary hair follicles in older cashmere goats, thus delaying skin aging, improving follicle survival, and increasing the number of secondary hair follicles. Collectively, these effects of exogenous MT enhanced the quality and yield of cashmere fibers, especially at 5–7 years old.

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Section: Discussionmentioning

confidence: 99%

Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFκB and AP-1

Diao

Duan

Yao

et al. 2023

IJMS

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“…Shamsalddini et al [85] showed that the CC genotype had the longest fibers compared to the AA and AC genotypes (p < 0,05), while there was no significant association between the PRL gene genotypes and fiber diameter. These results imply that the PRL gene polymorphism can be used as a molecular marker to improve fiber formation without adversely affecting fiber diameter [82,84,86]. In the POU1F1 gene, a positive regulator for PRL, a polymorphism at 3' UTR was identified as a putative molecular marker for senior cashmere yield [100].…”

Section: Candidate Genesmentioning

confidence: 93%

Landmark native breed of the Orenburg goats: progress in its breeding and genetics and future prospects

Тарасова

Фролов

Лебедев

et al. 2022

Animal Biotechnology

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This paper reviews information about a unique and iconic breed of the Orenburg Oblast, the homeland and the only place where the best herds of Orenburg down-hair goats in Russia are concentrated. Three types of these small ruminant animals are widespread on the territory of the region: Orenburg purebred gray goats, Orenburg purebred white goats, as well as crossbred white goats of F1 White Don × White Orenburg. Currently, at the farms of the Orenburg region, animals are selected according to their phenotype, with selected traits being color, weight and length of down hair. In recent years, the Orenburg goat breed has become an object of genetic research using various marker systems including immunogenetic, microsatellite, mtDNA and SNP markers. Overall, these studies evidence about the uniqueness of the allele pool in the landmark native breed of the Orenburg goats, which is a complex dynamic genetic system, prioritizing its further in-depth genome research and breeding applications.

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“…The distinct regulation of primary and secondary HF morphogenesis and cycling has been shown in mice and Cashmere goat. 35,155 Depending on the factors that are deregulated and in which stage the different HFs are in at the onset of the deregulation, different HC stages or HF types may be affected. As a consequence, either anagen induction, anagen promotion or cytodifferentiation, catagen induction, catagen promotion, telogen induction or telogen promotion or several of these stages are impaired and the HC disturbance may affect all or only some HF types.…”

Section: Hair Cycle Disturbance/arrestmentioning

confidence: 99%

Canine noninflammatory alopecia: An approach to its classification and a diagnostic aid

Welle

2023

Vet Pathol

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Noninflammatory alopecia is common in dogs and is a frequent cause to consult a veterinarian. It is also a common reason to take biopsies. Noninflammatory alopecia can be attributed to a decreased formation or cytodifferentiation of the hair follicle or the hair shaft in utero, resulting in congenital alopecia. Congenital alopecia often has a hereditary cause, and examples of such disorders are ectodermal dysplasias associated with gene variants of the ectodysplasin A gene. Noninflammatory alopecia may also be caused by impaired postnatal regeneration of hair follicles or shafts. Such disorders may have a clear breed predilection, and alopecia starts early in life. A hereditary background is suspected in those cases but has not been proven. They are referred to as follicular dysplasia although some of these disorders present histologically like a hair cycle disturbance. Late-onset alopecia is usually acquired and may be associated with endocrinopathies. Other possible causes are impaired vascular perfusion or stress. As the hair follicle has limited possible responses to altered regulation, and histopathology may change during the course of a disease, a detailed clinical history, thorough clinical examination including blood work, appropriate biopsy site selection, and detailed histological findings need to be combined to achieve a final diagnosis. This review aims to provide an overview about the known noninflammatory alopecic disorders in dogs. As the pathogenesis of most disorders is unknown, some statements are based on comparative aspects or reflect the authors’ opinion.

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Inhibition of prolactin promotes secondary skin follicle activation in cashmere goats

Cited by 10 publications

References 53 publications

Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFκB and AP-1

Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFκB and AP-1

Landmark native breed of the Orenburg goats: progress in its breeding and genetics and future prospects

Canine noninflammatory alopecia: An approach to its classification and a diagnostic aid

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