Effects of maternal obesity on antenatal, perinatal and neonatal outcomes

Avci, Muhittin Eftal; Şanlıkan, Fatih; Çelık, Mehmet; Avcı, Anıl; Kocaer, Mustafa; Göçmen, Ahmet

doi:10.3109/14767058.2014.978279

Cited by 63 publications

(48 citation statements)

References 16 publications

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“…The present study results illustrated that appropriate and normal nutrition status before pregnancy impacted the outcome of pregnancy (infants' weight at birth). This finding was in agreement with that of other studies (20). It is noteworthy that the two groups of infants with low weight and macrosomia experience similar complications in later life stages (27,28).…”

Section: Discussionsupporting

confidence: 93%

“…A association has been observed between obesity in the mother and premature birth (17); however, some studies have reported contradictory results (18,19). A higher prevalence of premature rupture of membrane (PROM), shoulder dystocia, meconiumstained amniotic fluid, fetal arrhythmia, and fetal macrosomia was reported in obese mothers in the study by Avc (20). Studies on malnutrition in the form of an overweight and underweight appearance, its impact on pregnancy outcome, premature birth, and LBW have reported contradictory results (17,19).…”

Section: Introductionmentioning

confidence: 98%

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The prevalence of malnutrition and its association with pregnancy outcome among pregnant women in Rafsanjan, Iran, in 2016

Salem

Ebrahimi

Aminzadeh

et al. 2017

JOHE

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Received: May 2017, Accepted: July 2017Background: Malnutrition in both its forms of obesity and underweight, particularly in pregnant women, cause maternal mortality and prenatal complications. The aims of this study were to determine the prevalence of malnutrition among pregnant women and its effect on ‫‬ ‫‬ ‫‬ pregnancy outcome, in Rafsanjan, Iran, in 2016. Materials and Methods:The present cross-sectional study was conducted on 839 pregnant women referred to Niknafs and Ali-Ebn Abitaleb Hospitals in 2016. The subjects were selected by census method. Data [age, pregnancy age, pre-gestational height and weight, and body mass index (BMI)] were collected in the emergency ward and recorded in a checklist. Information on the type of delivery (normal or cesarean section), and the neonate's gender, weight, height, and head circumference at birth were collected in the maternity ward. Data were analyzed using one-way ANOVA, Fisher's exact test, and chi-square test. Results: This study showed that the prevalence of pregestational overweight & obesity, and underweight was 37.5% and 7.4%, respectively. The prevalence of neonatal LBW and HBW was 5.1% and 3.8%, respectively. In addition, 9.7% of underweight women had LBW neonatals, and 11.8% of women with pregestational obesity had HBW infants (P = 0.039). Conclusions:The prevalence of obesity in pregnant women was higher than that reported in other studies in different regions of Iran. Therefore, obesity is a warning for health politicians and administrators. Although prenatal care has been able to control neonatal LBW and HBW, although there is a long way until the achievement of the nutritional goals for 2025.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 98%

The prevalence of malnutrition and its association with pregnancy outcome among pregnant women in Rafsanjan, Iran, in 2016

Salem

Ebrahimi

Aminzadeh

et al. 2017

JOHE

View full text Add to dashboard Cite

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“…Similar findings have been previously described [14,16,26,27]. Additionally, we found fewer SGA infants in obese mothers and, similar to our findings, Avci et al showed a higher rate of low birth weight infants in mothers with lower BMI [36]. We also found that infants had lower mean blood glucose levels and were more likely to be LGA and less likely to be SGA if they were born to obese versus non-obese mothers in the diet -only treatment group.…”

Section: Discussionsupporting

confidence: 81%

Maternal Obesity, Maternal Gestational Diabetes Mellitus, and Maternal and Neonatal Outcomes

AT¹

2016

J Obes Weight Loss Ther

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We aimed to investigate the co-morbid effects of maternal obesity, Gestational Diabetes Mellitus (GDM), and GDM treatment options on maternal and neonatal outcomes in an inner-city population. This is a retrospective chart review study of singleton mothers with new diagnosis of GDM and their infants during a 3-year period. During the study period, 356 women ages 13-48 years with GDM gave birth to 180 males and 175 females. Majority of mothers were African American (50.8%) and had Medicaid insurance (75.8%). Obese mothers constituted 48.3% of the study population, had a higher prevalence of pregnancy induced hypertension/preeclampsia, more commonly were managed with medication and delivered by C-section than non-obese mothers. Infants of obese GDM mothers had significantly higher mean birth weight, lower mean blood glucose, and were less at risk for Small for Gestational Age (SGA). In obese mothers, heaviest mothers had infants with higher bilirubin levels than less heavy mothers. We also observed a high rate of feeding difficulty in infants of GDM mothers (12.4%). Our study emphasizes the burden of maternal obesity as a major risk factor for both maternal and neonatal poor outcomes in the context of GDM and calls for further prospective and interventional research.

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“…Infants of obese mothers are prone to develop hyperinsulinemia and hypoglycemia in the neonatal period (Avci et al 2015), which may, in part, be due to the development of GDM in some obese mothers (Desoye and van Poppel, 2015). Animal studies have shown that maternal obesogenic diets induce insulin resistance in the dam and increase fetal blood glucose levels leading to accelerated pancreatic β-cell maturation and impaired glucose tolerance in the offspring (Ford et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of maternal obesity on placental function and fetal development

2017

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Obesity has reached epidemic proportions and pregnancies in obese mothers have increased risk for complications including gestational diabetes, hypertensive disorders, preterm birth and caesarian section. Children born to obese mothers are at increased risk of obesity and metabolic disease and are susceptible to develop neuropsychiatric and cognitive disorders. Changes in placental function not only play a critical role in the development of pregnancy complications but may also be involved in linking maternal obesity to long-term health risks in the infant. Maternal adipokines i.e., interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), leptin and adiponectin link maternal nutritional status and adipose tissue metabolism to placental function. Adipokines and metabolic hormones have direct impact on placental function by modulating placental nutrient transport. Nutrient delivery to the fetus is regulated by a complex interaction between insulin signaling, cytokine profile and insulin responsiveness, which is modulated by adiponectin and IL-1β. In addition, obese pregnant women are at risk for hypertension and preeclampsia with reduced placental vascularity and blood flow, which would restrict placental nutrient delivery to the developing fetus. These sometimes opposing signals regulating placental function may contribute to the diversity of short and long-term outcomes observed in pregnant obese women. This review focuses on the changes in adipokines and obesity-related metabolic hormones, how these factors influence placental function and fetal development to contribute to long-term metabolic and behavioral consequences of children born to obese mothers.

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Effects of maternal obesity on antenatal, perinatal and neonatal outcomes

Abstract: We conclude that obesity is an important factor associated with pregnancy complications and the increase in maternal-fetal morbidity and mortality.

Cited by 63 publications

References 16 publications

The prevalence of malnutrition and its association with pregnancy outcome among pregnant women in Rafsanjan, Iran, in 2016

The prevalence of malnutrition and its association with pregnancy outcome among pregnant women in Rafsanjan, Iran, in 2016

Maternal Obesity, Maternal Gestational Diabetes Mellitus, and Maternal and Neonatal Outcomes

Effects of maternal obesity on placental function and fetal development

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