2019
DOI: 10.1016/j.lfs.2018.12.039
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Effects of maternal bisphenol A on behavior, sex steroid and thyroid hormones levels in the adult rat offspring

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Cited by 32 publications
(11 citation statements)
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“…Sex-related differences in the relationship between BPA and THs were reported both in the general population [142] and in newborns [143,148], coherently with studies performed in rats [112,115], and possibly attributable to a less efficient ability to metabolize BPA, i.e., a reduced expression of uridinediphosphate-glucuronosyltransferase 2B1 in male compared to female livers [153], or to a different androgen-related metabolism of BPA [154].…”
Section: Effects On Serum Th Levelssupporting
confidence: 69%
See 1 more Smart Citation
“…Sex-related differences in the relationship between BPA and THs were reported both in the general population [142] and in newborns [143,148], coherently with studies performed in rats [112,115], and possibly attributable to a less efficient ability to metabolize BPA, i.e., a reduced expression of uridinediphosphate-glucuronosyltransferase 2B1 in male compared to female livers [153], or to a different androgen-related metabolism of BPA [154].…”
Section: Effects On Serum Th Levelssupporting
confidence: 69%
“…It is still unclear whether exposure to BPA and its derivatives can cause hypothyroidism due to limited evidence. A decrease in T4 levels was found in male and female adult rodents [110,113,114] and in rat pups of both sexes [114] or with a sex-specific effect [112,115]. The competition of BPs with TTR, as observed in vitro [70,84,92], resulting in a portion of serum T4 displaced from TTR, could determine an increased rate of T4 metabolism and elimination and the consequent reduction of T4 circulating levels [110].…”
Section: Rodentsmentioning
confidence: 94%
“…More recently, it has been demonstrated that exposure of rats to BPA during gestation and lactation, even at low doses (10 μg/kg/day), induces life-long dimorphic changes in metabolic homeostasis of the offspring: at weaning, female pups have higher plasma cholesterol and triacylglycerol levels than males, while at adult age, males have lower visceral fat than females. Notably, only females show hyperactivity suggesting that BPA can induce sex-dependent changes in behavior [ 107 ]. Maternal exposure to BPA may interfere with developmental programs in offspring, producing adverse outcomes, specifically altering the dimorphic development of many neuronal networks [ 108 ].…”
Section: Modulation Of Mva Pathway By Endogenous and Exogenous Commentioning
confidence: 99%
“…[10][11][12] Early exposure demonstrated that EDCs can indirectly act through changes in maternal endocrine status (i.e. plasma hormone levels) 13 and/or nutritional behavior. Hence, this can predispose newborns to nutritional and endocrine imbalances, adipocyte endocrine dysfunction, obesity, and related disorders.…”
Section: Introductionmentioning
confidence: 99%