Effects of maternal bisphenol A on behavior, sex steroid and thyroid hormones levels in the adult rat offspring

Silva, B.S.; Bertasso, Iala Milene; Pietrobon, Carla Bruna; Lopes, Bruna Pereira; Santos, T.R.; Peixoto-Silva, Nayara; Carvalho, Janaíne Cavalcanti; Claudio-Neto, S.; Manhães, Alex C.; Cabral, S.S.; Kluck, George Eduardo Gabriel; Atella, Geórgia C.; Oliveira, Elaine de; Moura, Egberto Gaspar de; Lisboa, Patrícia Cristina

doi:10.1016/j.lfs.2018.12.039

Cited by 33 publications

(14 citation statements)

References 83 publications

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“…Sex-related differences in the relationship between BPA and THs were reported both in the general population [142] and in newborns [143,148], coherently with studies performed in rats [112,115], and possibly attributable to a less efficient ability to metabolize BPA, i.e., a reduced expression of uridinediphosphate-glucuronosyltransferase 2B1 in male compared to female livers [153], or to a different androgen-related metabolism of BPA [154].…”

Section: Effects On Serum Th Levelssupporting

confidence: 69%

“…It is still unclear whether exposure to BPA and its derivatives can cause hypothyroidism due to limited evidence. A decrease in T4 levels was found in male and female adult rodents [110,113,114] and in rat pups of both sexes [114] or with a sex-specific effect [112,115]. The competition of BPs with TTR, as observed in vitro [70,84,92], resulting in a portion of serum T4 displaced from TTR, could determine an increased rate of T4 metabolism and elimination and the consequent reduction of T4 circulating levels [110].…”

Section: Rodentsmentioning

confidence: 94%

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Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence

Gorini

Bustaffa

Coi

et al. 2020

IJERPH

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Bisphenols (BPs), and especially bisphenol A (BPA), are known endocrine disruptors (EDCs), capable of interfering with estrogen and androgen activities, as well as being suspected of other health outcomes. Given the crucial role of thyroid hormones and the increasing incidence of thyroid carcinoma in the last few decades, this review analyzes the effects of BPS on the thyroid, considering original research in vitro, in vivo, and in humans published from January 2000 to October 2019. Both in vitro and in vivo studies reported the ability of BPs to disrupt thyroid function through multiple mechanisms. The antagonism with thyroid receptors (TRs), which affects TR-mediated transcriptional activity, the direct action of BPs on gene expression at the thyroid and the pituitary level, the competitive binding with thyroid transport proteins, and the induction of toxicity in several cell lines are likely the main mechanisms leading to thyroid dysfunction. In humans, results are more contradictory, though some evidence suggests the potential of BPs in increasing the risk of thyroid nodules. A standardized methodology in toxicological studies and prospective epidemiological studies with individual exposure assessments are warranted to evaluate the pathophysiology resulting in the damage and to establish the temporal relationship between markers of exposure and long-term effects.

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Section: Effects On Serum Th Levelssupporting

confidence: 69%

Section: Rodentsmentioning

confidence: 94%

Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence

Gorini

Bustaffa

Coi

et al. 2020

IJERPH

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“…More recently, it has been demonstrated that exposure of rats to BPA during gestation and lactation, even at low doses (10 μg/kg/day), induces life-long dimorphic changes in metabolic homeostasis of the offspring: at weaning, female pups have higher plasma cholesterol and triacylglycerol levels than males, while at adult age, males have lower visceral fat than females. Notably, only females show hyperactivity suggesting that BPA can induce sex-dependent changes in behavior [ 107 ]. Maternal exposure to BPA may interfere with developmental programs in offspring, producing adverse outcomes, specifically altering the dimorphic development of many neuronal networks [ 108 ].…”

Section: Modulation Of Mva Pathway By Endogenous and Exogenous Commentioning

confidence: 99%

Impact of Sex and Age on the Mevalonate Pathway in the Brain: A Focus on Effects Induced by Maternal Exposure to Exogenous Compounds

2020

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The mevalonate pathway produces cholesterol and other compounds crucial for numerous cellular processes. It is well known that age and sex modulate this pathway in the liver. Recently, similar effects were also noted in different brain areas, suggesting that alterations of the mevalonate pathway are at the root of marked sex-specific disparities in some neurodevelopmental disorders related to disturbed cholesterol homeostasis. Here, we show how the mevalonate pathway is modulated in a sex-, age- and region-specific manner, and how maternal exposure to exogenous compounds can disturb the regulation of this pathway in the brain, possibly inducing functional alterations.

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“…[10][11][12] Early exposure demonstrated that EDCs can indirectly act through changes in maternal endocrine status (i.e. plasma hormone levels) 13 and/or nutritional behavior. Hence, this can predispose newborns to nutritional and endocrine imbalances, adipocyte endocrine dysfunction, obesity, and related disorders.…”

Section: Introductionmentioning

confidence: 99%

Relationship between endocrine disruptors and obesity with a focus on bisphenol A: a narrative review

et al. 2020

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Introduction: Scientific data suggest that early exposure to endocrine-disrupting chemicals (EDCs) affect -repro, -neuro, -metabolic systems, to which are added other notions such as mixtures, window and duration of exposure, trans-generational effects, and epigenetic mechanisms. Methods: In the present narrative review, we studied the relationship between exposure to EDCs with the appearance and development of obesity. Results: Exposure to EDCs like Bisphenol A during the early stages of development has been shown to lead to weight gain and obesity. EDCs can interfere with endocrine signaling, affect adipocytes differentiation and endocrine function and disrupt metabolic processes, especially if exposure occurs at very low doses, in the mixture, during early development stages for several generations. Conclusion: Exposure to EDCs is positively associated with obesity development. Moreover, the use of integrative approaches which mimicking environmental conditions are necessary and recommended to evaluate EDCs' effects in future studies.

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Effects of maternal bisphenol A on behavior, sex steroid and thyroid hormones levels in the adult rat offspring

Cited by 33 publications

References 83 publications

Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence

Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence

Impact of Sex and Age on the Mevalonate Pathway in the Brain: A Focus on Effects Induced by Maternal Exposure to Exogenous Compounds

Relationship between endocrine disruptors and obesity with a focus on bisphenol A: a narrative review

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