Relationship between endocrine disruptors and obesity with a focus on bisphenol A: a narrative review

Boudalia, Sofiane; Bousbia, Aissam; Boumaaza, Boualem; Oudir, Malha; Lavier, Marie Chantal Canivenc

doi:10.34172/bi.2021.33

Cited by 10 publications

(6 citation statements)

References 109 publications

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“…The data available in the literature indicate that intrauterine exposure to EDs may contribute to obesity, insulin resistance, dyslipidemia, thyroid dysfunctions, infertility or a cancerous process in adulthood [ 58 ]. Studies have revealed that EDs may not only lead to an increase in adipocyte number and size, but may also disrupt the hormonal regulation processes involved in the maturation of adipose tissue [ 59 , 60 ]. In 2017, Darbre proposed the idea of the existence of the vicious circle mechanism, in which EDs increase the amount of adipose tissue in the body.…”

Section: Endocrine Disruptorsmentioning

confidence: 99%

A Brief Look at Hashimoto’s Disease, Adrenal Incidentalomas, Obesity and Insulin Resistance—Could Endocrine Disruptors Be the Other Side of the Same Coin?

et al. 2023

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Hashimoto’s disease (HD) is the most common cause of hypothyroidism in developed countries. The exact pathomechanism behind it has not been clearly established; however, an interplay of genetic susceptibility, environmental triggers (including diet) and epigenetic factors seems to be involved. Among the latter, increasingly more attention has been paid to some hormonally active substances, known as endocrine disruptors, which are commonly used worldwide. HD has become a condition widely reported in the media, acting as a culprit for inexplicable weight gain, chronic fatigue or weakness. Nevertheless, the recognition of HD is undeniably increasing and represents a major public health burden. At the same time, improving access to imaging tests has increased the number of incidentally diagnosed adrenal tumors. Above all, the widespread use of chest computed tomography (CT) due to the COVID-19 pandemic has contributed to frequent incidental detection of adrenal lesions. Fortunately, a vast majority of these findings are asymptomatic benign tumors with no excessive hormonal activity, and therefore, they are defined as adrenal incidentalomas (AIs). Interestingly, recent studies have indicated that patients with AIs are more prone to obesity and insulin resistance. Although mutual relationships between the thyroid and the adrenal glands have been studied widely, still, little is known about the possible pathophysiological associations between thyroid autoimmunity and the occurrence of adrenal incidentalomas. This article presents a brief review of the common endocrine disorders with a special focus on the frequently coexisting insulin resistance and/or obesity. Furthermore, in response to the recent growing interest in endocrine disruptors, with their transgenerational epigenetic effects that influence hormonal system function, a concise overview of the topic has also been included.

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Section: Endocrine Disruptorsmentioning

confidence: 99%

A Brief Look at Hashimoto’s Disease, Adrenal Incidentalomas, Obesity and Insulin Resistance—Could Endocrine Disruptors Be the Other Side of the Same Coin?

et al. 2023

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“…The hypothesis of obesogens in the environment purports that pollutants of a chemical nature have the capacity to induce excess weight modifying metabolism and homeostatic set-points, affecting appetite regulation, altering lipid metabolism to stimulate adipocyte hypertrophy, and promoting adipogenic pathways aimed at fat cell hyperplasia, thereby predisposing, initiating or exacerbating weight gain [92,93]. Phthalates, per-and polyfluoroalkyl substances, polycyclic aromatic hydrocarbons, bisphenol A (BPA), heavy metals (cadmium, arsenic and mercury), and pesticides are well-known EDCs [94]. Important concepts regarding the potential impact of EDC include window and duration of exposure, role of combinations or mixtures, transgenerational effects, and epigenetic mechanisms.…”

Section: Endocrine Disrupters-obesogensmentioning

confidence: 99%

“…Important concepts regarding the potential impact of EDC include window and duration of exposure, role of combinations or mixtures, transgenerational effects, and epigenetic mechanisms. EDCs interrupt hormonal signaling, alter adipocyte differentiation, and interfere with metabolism, in particular during early developmental stages for several generations [94]. Various EDCs like BPA, diethylstilbestrol, phthalates and organotins, to mention a few, can interfere with signaling by targeting pathways of nuclear hormone receptors (glucocorticoid receptors, sex steroid, retinoid X receptor, and peroxisome proliferator-activated receptor γ) relevant to adipocyte proliferation and differentiation.…”

Section: Endocrine Disrupters-obesogensmentioning

confidence: 99%

Time to Consider the “Exposome Hypothesis” in the Development of the Obesity Pandemic

et al. 2022

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The obesity epidemic shows no signs of abatement. Genetics and overnutrition together with a dramatic decline in physical activity are the alleged main causes for this pandemic. While they undoubtedly represent the main contributors to the obesity problem, they are not able to fully explain all cases and current trends. In this context, a body of knowledge related to exposure to as yet underappreciated obesogenic factors, which can be referred to as the “exposome”, merits detailed analysis. Contrarily to the genome, the “exposome” is subject to a great dynamism and variability, which unfolds throughout the individual’s lifetime. The development of precise ways of capturing the full exposure spectrum of a person is extraordinarily demanding. Data derived from epidemiological studies linking excess weight with elevated ambient temperatures, in utero, and intergenerational effects as well as epigenetics, microorganisms, microbiota, sleep curtailment, and endocrine disruptors, among others, suggests the possibility that they may work alone or synergistically as several alternative putative contributors to this global epidemic. This narrative review reports the available evidence on as yet underappreciated drivers of the obesity epidemic. Broadly based interventions are needed to better identify these drivers at the same time as stimulating reflection on the potential relevance of the “exposome” in the development and perpetuation of the obesity epidemic.

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“…Previous reviews have discussed the relationship between prenatal BPA exposure and its effects on a wide variety of metabolic disorders, such as obesity and T2DM [21][22][23][24][25]. However, when we scrutinised the outcomes of the studies, we discovered a controversy regarding the effect of BPA in the findings of the studies.…”

Section: Introductionmentioning

confidence: 99%

The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence

2022

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Metabolic syndrome (MS) is a multifactorial disease entity and is not fully understood. Growing evidence suggests that early exposure to bisphenol A (BPA) is a significant risk factor for the development of metabolic diseases. BPA is a monomer used in the manufacturing of polycarbonate plastics, thermal receipt paper, and epoxy resins. Owing to its widespread use, BPA has been detected in human fluids and tissues, including blood, placental breast milk, and follicular fluid. In the present review, we aimed to review the impact of prenatal exposure to different doses of BPA on metabolic parameters as determined by in vivo and epidemiological studies. The PubMed, Scopus, and Web of Science electronic databases were searched to identify articles published during a period of 15 years from 2006 to 2021, and 29 studies met the criteria. Most studies demonstrated that prenatal exposure to low BPA concentrations correlated with alterations in metabolic parameters in childhood and an increased risk of metabolic diseases, such as obesity and type 2 diabetes mellitus (T2DM), in adulthood. Therefore, prenatal exposure to low doses of BPA may be associated with an increased risk of obesity and T2DM in a sex-specific manner.

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Relationship between endocrine disruptors and obesity with a focus on bisphenol A: a narrative review

Cited by 10 publications

References 109 publications

A Brief Look at Hashimoto’s Disease, Adrenal Incidentalomas, Obesity and Insulin Resistance—Could Endocrine Disruptors Be the Other Side of the Same Coin?

A Brief Look at Hashimoto’s Disease, Adrenal Incidentalomas, Obesity and Insulin Resistance—Could Endocrine Disruptors Be the Other Side of the Same Coin?

Time to Consider the “Exposome Hypothesis” in the Development of the Obesity Pandemic

The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence

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