Effects of maternal antioxidant supplementation on maternal and fetal antioxidant levels: a randomized, double-blind study

Pressman, Eva; Cavanaugh, Judith L.; Mingione, Matthew; Norkus, Edward P.; Woods, James R.

doi:10.1016/s0002-9378(03)00858-5

Cited by 48 publications

(30 citation statements)

References 20 publications

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“…Experimental data from cell culture, animal models and tissue studies have provided evidence that pro-inflammatory cytokines and prostaglandins accumulate in the amniotic fluid and intrauterine tissues of women at the time of labour at term, and they are elevated even further in infection-associated preterm labour. Further, oxidative stress also plays a role during normal parturition (Fainaru et al 2002, Mocatta et al 2004 in the initiation of preterm labour (Wall et al 2002, Pressman et al 2003, and in preterm, premature rupture of the membranes (Wall et al 2002). Therefore, enhanced AGE and/or RAGE formation may contribute to the raised circulating levels of pro-inflammatory mediators that are evident in this state.…”

Section: Discussionmentioning

confidence: 99%

Advanced glycation endproducts mediate pro-inflammatory actions in human gestational tissues via nuclear factor-κB and extracellular signal-regulated kinase 1/2

Lappas¹,

Permezel²,

Rice³

2007

Journal of Endocrinology

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Processes of human labour include increased oxidative stress, formation of inflammatory mediators (e.g. cytokines) and uterotonic phospholipid metabolites (e.g. prostaglandins). In non-gestational tissues, advanced glycation endproducts (AGE) induce the expression of pro-inflammatory molecules through mitogen-activated protein kinase and nuclear factor kB (NF-kB)-dependent pathways. Thus, the aim of this study was to investigate the effects of AGE on 8-isoprostane (a marker of oxidative stress), pro-inflammatory cytokine and prostaglandin release in human gestational tissues, and to define the signalling pathways involved. Human placenta and gestational membranes (amnion and choriodecidua combined; nZ5) were incubated in the absence or presence of AGE-BSA (0 . 25, 0 . 5, 1 and 2 mg/ml) for 18 h. AGE significantly increased in vitro release of tumour necrosis factor-a, interleukin (IL)-1b, IL-6, IL-8, prostaglandin (PG)E 2 , PGF 2a and 8-isoprostane from human placenta and gestational membranes. This was associated with a concomitant increase in NF-kB p65 activation and ERK 1/2 phosphorylation. AGE-stimulated 8-isoprostane, cytokine and prostaglandin production was significantly suppressed by the ERK 1/2 inhibitor U0126 and the NF-kB inhibitor BAY 11-7082. In conclusion, AGE mediates inflammatory actions in human gestational tissues. Protein kinases and the NF-kB pathway play an essential role in AGE signalling in human gestational tissues.

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Section: Discussionmentioning

confidence: 99%

Advanced glycation endproducts mediate pro-inflammatory actions in human gestational tissues via nuclear factor-κB and extracellular signal-regulated kinase 1/2

Lappas¹,

Permezel²,

Rice³

2007

Journal of Endocrinology

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“…In an RCT (Pressman et al, 2003), pregnant women received from week 35 of gestation onwards a daily prenatal vitamin C-and 'vitamin E'-containing supplement (containing 120 mg vitamin C and 30 IU 'vitamin E', which would be equivalent to 20.1 mg/day of α-tocopherol), either with or without additional 500 mg vitamin C and 'vitamin E' (400 IU, which would be equivalent to 268 mg/day of α-tocopherol). Mean maternal plasma α-tocopherol concentrations were 31.3 µmol/L and 50.4 µmol/L at delivery in each group, while cord plasma α-tocopherol at delivery was only 6.97 µmol/L in both groups (differences between groups not statistically significant).…”

Section: Pregnant or Lactating Womenmentioning

confidence: 99%

Scientific Opinion on Dietary Reference Values for vitamin E as α‐tocopherol

Products¹

2015

EFS2

108

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Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for vitamin E. In this Opinion, the Panel considers vitamin E as α-tocopherol only. The Panel considers that Average Requirements (ARs) and Population Reference Intakes (PRIs) for vitamin E (as α-tocopherol) cannot be derived for adults, infants and children, and therefore defines Adequate Intakes (AIs), based on observed intakes in healthy populations with no apparent α-tocopherol deficiency in the EU. This approach considers the range of average intakes of α-tocopherol and of α-tocopherol equivalents estimated by EFSA from dietary surveys in children and adults in nine countries. The Panel notes the uncertainties in the available food composition and consumption data, the fact that most EU food composition databases contain values for vitamin E as α-tocopherol equivalents, as well as the contribution of average α-tocopherol intakes to average α-tocopherol equivalent intakes in these countries. For adults, an AI for α-tocopherol is set at 13 mg/day for men and 11 mg/day for women. For children aged 1 to < 3 years, an AI for α-tocopherol is set at 6 mg/day for both sexes. For children aged 3 to < 10 years, an AI for α-tocopherol is set at 9 mg/day for both sexes. For children aged 10 to < 18 years, an AI for α-tocopherol is set at 13 mg/day for boys and 11 mg/day for girls. For infants aged 7-11 months, an AI for α-tocopherol of 5 mg/day is derived by extrapolating upwards from the estimated α-tocopherol intake in exclusively breast-fed infants aged 0-6 months and rounding. For pregnant or lactating women, the Panel considers that there is no evidence for an increased dietary α-tocopherol requirement, and the same AI is set as for non-pregnant non-lactating women. Vitamin E is a fat-soluble vitamin. Previously, the term vitamin E was used as the generic term for four tocopherols (α, β, γ, δ) and four tocotrienols (α, β, γ, δ), which are organic compounds that possess antioxidant activity to a different degree. Factors have been used to convert food contents of tocopherols and tocotrienols to α-tocopherol equivalents. In this Opinion, based on the available evidence and in line with other authoritative bodies, the Panel considers vitamin E as being α-tocopherol only. Its naturally occurring form is RRR-α-tocopherol. Commercially available forms of α-tocopherol include RRR-α-tocopherol, a synthetic form that contains in equal proportions the eight stereoisomers of α-tocopherol (RRR-, RRS-, RSR-, RSS-and their enantiomers SSS-, SSR-, SRS-, SRR-) and is called all-rac-α-tocopherol, and their esterified forms. © EuropeanEfficient α-tocopherol absorption requires the presence of fat. The Panel considered that the average α-tocopherol absorption from a usual diet is about 75 %. This is based on the means observed in two balance studies and in a kinetic study using a multi-compartmental model of α-tocopherol metabolism. After its intestinal absorption, α-toc...

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“…Further, increased oxidative stress was also observed during labor [31][32][33][34][35]. Therefore, nitrotryosine, an indicator of oxidative stress, was measured in placental tissue.…”

Section: Immunohistochemical Study Of Human Placental Tissuementioning

confidence: 99%

Mammalian Ste20-like protein kinase 3 mediates trophoblast apoptosis in spontaneous delivery

Lin

Lin³

et al. 2007

Apoptosis

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The placenta is essential in transferring gases and nutrients from the mother to the developing fetus. Trophoblast apoptosis may cause labor or other pregnancy-related disorders. This study demonstrated the essential role of Mst3, a human Ste20-like protein kinase, in the oxidative stress-induced apoptosis of trophoblasts of term placenta in normal spontaneous delivery. Oxidative stress, but not hormones released during labor such as prostaglandin E1, oxytocin or angiotensin II, induces the expression of Mst3 and apoptosis of human term placenta after elective Cesarean section without labor pain. The role of Mst3 in oxidative stress-induced apoptosis was further demonstrated in the 3A-sub-E, a human trophoblast cell line. The H2O2-induced apoptosis of 3A-sub-E cells was largely suppressed by overexpressed Mst3KR, the kinase-dead mutant or by selective knockdown of endogenous Mst3. Further studies showed that Jun N-terminal kinase (JNK) may participate in the signaling pathway of H2O2-induced apoptosis by mediating the level of Mst3. Subsequently, caspase 3 and other downstream apoptotic components may be activated by Mst3 and trigger the apoptotic process in human trophoblasts.

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Effects of maternal antioxidant supplementation on maternal and fetal antioxidant levels: a randomized, double-blind study

Cited by 48 publications

References 20 publications

Advanced glycation endproducts mediate pro-inflammatory actions in human gestational tissues via nuclear factor-κB and extracellular signal-regulated kinase 1/2

Advanced glycation endproducts mediate pro-inflammatory actions in human gestational tissues via nuclear factor-κB and extracellular signal-regulated kinase 1/2

Scientific Opinion on Dietary Reference Values for vitamin E as α‐tocopherol

Mammalian Ste20-like protein kinase 3 mediates trophoblast apoptosis in spontaneous delivery

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