Effects of magnesium sulphate on intraoperative neuromuscular blocking agent requirements and postoperative analgesia in children with cerebral palsy

Na, H.-S.; Lee, J.-H.; Hwang, Jung‐Won; Ryu, Jung Hee; Han, Sung Hee; Jeon, Young Tae; Hwan, Sang

doi:10.1093/bja/aep379

Cited by 55 publications

(58 citation statements)

References 35 publications

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“…Studies by Na et al, [29] Benhaj et al [17] and Hwang et al [31] are consistent with our finding that there existed an inverse relation between the dose of magnesium infused and total dose of morphine required. They say that post-operative serum magnesium was higher in magnesium infused group which consumed less post-operative analgesia.…”

Section: Discussionsupporting

confidence: 93%

“…Analysis on studies in patients undergoing general anaesthesia showed that post-operative pain scores was significantly low in magnesium infused group. [14,17,[29][30] Studies on peri-operative IV magnesium done in patients undergoing spinal anaesthesia also reported significantly lower mean pain score. [31][32][33] Post-operative pain scores were also lower when magnesium was infused epidurally.…”

Section: Discussionmentioning

confidence: 98%

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A Study on Peri - Operative Magnesium Sulphate on Post - Operative Pain Management in Patients Undergoing Pelvic and Lower Limb Surgeries

Sebastian¹,

Abraham²,

Rajkumar³

et al. 2015

jemds

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 98%

A Study on Peri - Operative Magnesium Sulphate on Post - Operative Pain Management in Patients Undergoing Pelvic and Lower Limb Surgeries

Sebastian¹,

Abraham²,

Rajkumar³

et al. 2015

jemds

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“…The results of the aforementioned study were almost similar to our findings. In a study by Na on 61 patients with cerebral palsy (CP) who had undergone orthopedic surgery, pain score, the dose of rocuronium, and the use of analgesic drugs in the group who had received 50 mg/kg of magnesium sulfate bolus injection and then 15 mg/kg during surgery was lower than the placebo group (17). In another study that was done in 2008 on 48 patients by Benhaj Amor, pain score and the amount of morphine consumption in the group who had received 50 mg/kg of magnesium sulfate before surgery and 0.5 g/h after surgery was lower compared to the group who had received normal saline.…”

Section: Discussionmentioning

confidence: 99%

The effect of intravenous magnesium sulfate infusion on reduction of pain after abdominal hysterectomy under general anesthesia: a double-blind, randomized clinical trial

et al. 2016

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BackgroundPost-surgical pain is a physiological response to tissue trauma that produces unpleasant physiological effects with manifestations on various organic systems.ObjectiveAccording to the effect of magnesium sulfate on the N-methyl-d-aspartate (NMDA) receptor, this study examined the effect of magnesium sulfate on the reduction of pain and the mean amount of narcotics consumed by patients after abdominal hysterectomies.MethodsThis double-blind clinical trial study was performed on 60 patients who had undergone abdominal hysterectomies in Shahid Sadoughi Hospital in Yazd, Iran, from 2013 to 2015. The patients were divided randomly into two groups of 30 members each. All of the patients received 2 mg of Midazolam and 2 mcg/kg of Fentanyl as the induction of anesthesia with propofol (2–2.5 mg/kg) and Atracurium 0.5 mg/kg was conducted. All of the patients received 5 mg of intravenous morphine 30 min after induction of anesthesia. Afterwards, the study group received 50 mg/kg of magnesium sulfate in 500 cm3 of Ringer’s serum during the 20 minutes, and 500 cm3 of Ringer’s serum was administered to the members of the placebo group. Visual analogue scale VAS scores were evaluated to reach the minimum difference of 0.8 in mean pain scoreResultsThe results of this study indicated that the mean pain scores immediately after surgery and at 1, 2, 6, and 12 hr after surgery were lower in the study group than in the placebo group. The mean value of narcotic consumption at all measured time points was higher in the placebo group. No significant differences were found between two groups concerning drug complications.ConclusionThe results of this study indicated that the intravenous injection of magnesium sulfate can reduce pain, reduce morphine consumption, and reduce the side effects of morphine in patients after surgery.FundingThis study was funded by Shahid Sadoughi University of Medical Sciences, Yazd, IranClinical trial registrationThe trial was registered at the Thai Clinical Trials Registry (http://www.clinicaltrials.in.th) with the registration ID: TCTR20160308001.

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“…Some authors have focused on the direct enhancing effects of magnesium on the neuromuscular blockade [37-40]. In contrast, others concluded that a perioperative adjuvant magnesium sulfate administration reduced requirements for nondepolarizing neuromuscular blockers [15,29,33,41-43]. …”

Section: Muscle Relaxationmentioning

confidence: 99%

Magnesium: a versatile drug for anesthesiologists

Hwan

2013

Korean J Anesthesiol

154

106

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Magnesium sulfate has been used in preeclampsia patients in order to prevent seizure. It is also used for the treatment of arrhythmia and asthma and as an anesthetic adjunct in patients undergoing surgery for pheochromocytoma. However, its potentiating effects on perioperative analgesia and muscle relaxation have drawn attention recently. These characteristics of magnesium (anesthetic- and analgesic-sparing effect) enable anesthesiologists to reduce the use of anesthetics during surgery and the use of analgesics after surgery. Magnesium sulfate has a high therapeutic index and cost-effectiveness. Considering these diverse characteristics useful for anesthesia, appropriate use of magnesium sulfate would improve surgical outcome and patients' satisfaction.

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Effects of magnesium sulphate on intraoperative neuromuscular blocking agent requirements and postoperative analgesia in children with cerebral palsy

Abstract: I.V. magnesium sulphate reduces rocuronium requirements and postoperative analgesic consumption in children with CP.

Cited by 55 publications

References 35 publications

A Study on Peri - Operative Magnesium Sulphate on Post - Operative Pain Management in Patients Undergoing Pelvic and Lower Limb Surgeries

A Study on Peri - Operative Magnesium Sulphate on Post - Operative Pain Management in Patients Undergoing Pelvic and Lower Limb Surgeries

The effect of intravenous magnesium sulfate infusion on reduction of pain after abdominal hysterectomy under general anesthesia: a double-blind, randomized clinical trial

Magnesium: a versatile drug for anesthesiologists

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