Magnesium: a versatile drug for anesthesiologists

Hwan, Sang

doi:10.4097/kjae.2013.65.1.4

Cited by 155 publications

(132 citation statements)

References 53 publications

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“…6,7 Magnesium has long been used for its antihypertensive, anesthetic sparing effects and its property to enhance the effects of analgesics. 8,9 Magnesium, after administration through epidural route, decreased postoperative opioid jOrapain consumption. 6 Magnesium as adjuvant enhances the analgesic properties of established analgesics; it needs to be evaluated further when used as an adjuvant in perineural injection with local anesthetic in supraclavicular block.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Magnesium Sulfate as Adjuvant to Ropivacaine 0.4% for Supraclavicular Brachial Plexus Block in Patients undergoing Upper Limb Surgery: A Randomized Controlled Trial

Gupta

Mangal

Sharma

et al. 2017

Journal on Recent Advances in Pain

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Objectives: To prolong the duration of brachial plexus block, different adjuvants have been used. We evaluated the effect of adding magnesium sulfate to local anesthetic ropivacaine 0.4% for institution of supraclavicular brachia plexus block. Onset of sensory and motor block, duration of motor block, and rescue analgesia were observed. Materials and methods:Total 120 patients (20-50 years) scheduled for elective surgeries of upper limb under supraclavicular brachial plexus block were randomized into two groups. Group I received 24 mL 0.5% ropivacaine (120 mg) + 6.0 mL normal saline (NS) to make total volume of 30 mL. Group II received 24 mL 0.5% ropivacaine (120 mg) + 150 mg magnesium sulfate + 5.5 mL NS to make total volume of 30 mL. Results:Onset of sensory block in group I was 16.63 ± 2.79 min and in group II was 17.33 ± 2.25 min (statistically not significant, p > 0.05). Onset of motor block in group I was 18.63 ± 2.79 min and in group II was 19.76 ± 2.18 min (statistically significant, p < 0.05). The duration of motor block was significantly longer in group II; 322.00 ± 81.35 min than group I; 260.25 ± 66.79 min (p < 0.05). Similarly, time of rescue analgesia was significantly prolonged in group II; 491 ± 100.22 min than group I; 377.67 ± 73.31 min (p < 0.05). Conclusion:From our study, we concluded that the addition of 150 mg magnesium sulfate as adjuvant to 30 mL of 0.4% ropivacaine in comparison to 30 mL of 0.4% ropivacaine provides longer duration of analgesia. Although the onset of sensory block is not affected, onset of motor block is delayed. Motor block lasts for longer duration.

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Section: Introductionmentioning

confidence: 99%

Efficacy of Magnesium Sulfate as Adjuvant to Ropivacaine 0.4% for Supraclavicular Brachial Plexus Block in Patients undergoing Upper Limb Surgery: A Randomized Controlled Trial

Gupta

Mangal

Sharma

et al. 2017

Journal on Recent Advances in Pain

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“…MgSO 4 has also been attributed certain antiemetic properties, which seems to be more related to a reduction of perioperative opioid consumption .…”

Section: Magnesium Sulfate In Pediatric Anesthesiamentioning

confidence: 99%

“…Magnesium sulfate heptahydrate (MgSO 4 Á7H 2 O) is the pharmaceutical preparation for Mg vials. In Spain, each 10 ml vial contains 1.5 g of MgSO 4 and 150 mg of Mg (6 mmol or 12 mEq) (2).…”

Section: Magnesium Sulfate Pharmacologymentioning

confidence: 99%

“…The main objective of this paper was to review the clinical use of magnesium sulfate (MgSO 4 ) as an adjuvant drug in the anesthetic management of pediatric patients. A preliminary commentary on the Mg physiology and homeostasis, as well as the most relevant pharmacological aspects of MgSO 4 , is also carried out. The literature search for this narrative review was conducted between January 2010 and May 2016, in the following databases and search engines: Google, Pubmed, Embase, and Medline.…”

Section: Introductionmentioning

confidence: 99%

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Magnesium sulfate in pediatric anesthesia: the Super Adjuvant

Rebollar

Palacios

Guerrero

et al. 2017

Pediatric Anesthesia

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Magnesium is an essential chemical element in all organisms, intervening in most cellular enzymatic reactions; thus, its importance in homeostasis and as a therapeutic tool in highly challenging patients such as pediatrics. The primary purpose of this paper was to review the role of magnesium sulfate as an adjuvant drug in pediatric anesthesia. This compound already has the scientific backing in certain aspects such as analgesia or muscle relaxation, but only theoretical or empirical backing in others such as organ protection or inflammation, where it seems to be promising. The multitude of potential applications in pediatric anesthesia, its high safety, and low cost make magnesium sulfate could be considered a Super Adjuvant.

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“…Yapılan bir çalışmada magnezyumun indüksiyon sonrası bolus yapıldığı takdirde peroperatif remifentanil ihtiyacını azalttığı da gösterilmiştir (7). Magnezyumun anestezide klinik kullanımı ile ilgili yapılan birçok çalışma mevcuttur (6,17,18). Elektif abdominal histereskopi yapılan hastalara operasyona başlamadan önce magnezyum verdiklerinde özellikle ağrının yoğun olduğu bilinen ilk 6 saatte, magnezyum uygulanmayan hastalarla karşılaştırıldığında opioid ihtiyaçlarının belirgin olarak azaldığı görülmüştür (19 (10).…”

Section: Introductionunclassified

Rejyonal İntravenöz Anestezi̇de Li̇dokai̇n İle Li̇dokai̇n Ve Magnezyum Kombi̇nasyonunun Karşilaştirilmasi

et al. 2015

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Objectives: RIVA (Regional Intravenous Anesthesia) is frequently preferred during distal upper extremity operations (hand, wrist and forearm) compared to general anesthesia because of the following reasons: lower operational cost, simplicity, surgical operation environment stability, quick implementation and faster recovery time. Deeper anesthesia, prolonged effective time, hemodynamic stabilization, reduced intraoperative complications and longer postoperative analgesia are aimed by using adjunct drugs. Main objective of our study is to investigate the effectiveness of magnesium as an adjunct in RIVA. Material & Methods:A set of 18-80 year old patients who were operated on upper extremity using RIVA at Istanbul University, Istanbul Medical Faculty, Department of Orthopedics between 2012 and 2013 were evaluated retrospectively for this study. Only adult subjects who are classified with ASA I and II preoperative physical condition were included. Patients were evaluated according to BMI (Body Mass Index), gender, ASA score, anesthesia success rate, hemodynamic stabilization, VAS (Visual Analogue Scale) score at 1st postoperative hour and for emergent adverse effects. Results: 40 RIVA patients were included in this study. 20 patients were anaesthetized using Magnesium (Group-M) and the other 20 patients were anaesthetized without using Magnesium (Group-K). No statistical differences were determined between the groups regarding demographic data. Comparison of hemodynamic parameters between Group-M and Group-K showed no significant difference (p<0,05). It is observed that VAS score comparisons do not indicate

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Magnesium: a versatile drug for anesthesiologists

Cited by 155 publications

References 53 publications

Efficacy of Magnesium Sulfate as Adjuvant to Ropivacaine 0.4% for Supraclavicular Brachial Plexus Block in Patients undergoing Upper Limb Surgery: A Randomized Controlled Trial

Efficacy of Magnesium Sulfate as Adjuvant to Ropivacaine 0.4% for Supraclavicular Brachial Plexus Block in Patients undergoing Upper Limb Surgery: A Randomized Controlled Trial

Magnesium sulfate in pediatric anesthesia: the Super Adjuvant

Rejyonal İntravenöz Anestezi̇de Li̇dokai̇n İle Li̇dokai̇n Ve Magnezyum Kombi̇nasyonunun Karşilaştirilmasi

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