Effects of lycopene on oxidative stress and remnant liver histology after partial hepatectomy in rats

Ayan, Faruk; Aytaç, Erman; Saygılı, Seha; Genc, Habibe; Karaca, Çetin; Bayrak, İbrahim; Uzun, Hafize; Salihoğlu, Ziya; Erdamar, Sibel; Sözer, Volkan; Altuğ, Tuncay; Seymen, Pınar; Seymen, Hakki Oktay

doi:10.4318/tjg.2011.0189

Cited by 4 publications

(3 citation statements)

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“…In rats, lipid peroxidation significantly increases 90 minutes after the generation of the liver ischemia (28). Hepatic functional tests are closely correlated with the MDA (29). Therefore, monitoring lipid peroxidation, gives a reliable impression on liver functions.…”

Section: Discussionmentioning

confidence: 99%

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Does taurolidine have any effect on liver regeneration and oxidation in the experimental hepatectomy model?

et al. 2021

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Objective: Taurolidine is a bicyclic molecule produced by the natural amino acid taurine. Antibacterial, antiendotoxic and cytoprotective effects of taurolidine have been shown experimentally. Data on the effects of taurolidine on oxidative stress and hepatic regeneration are limited. The aim of the study was to evaluate the effect of taurolidine on hepatic regeneration and oxidative stress in rats undergoing partial hepatectomy. Material and Methods: Forty adult, male Wistar Albino rats were randomly divided into four equal groups: sham (S) group (n= 10), post-sham opera- tion taurolidine administered (ST) group (n= 10), partial hepatectomy (H) group (n= 10) and post-partial hepatectomy taurolidine administered (HT) group (n= 10). 100 mg/kg/day taurolidine was administered for seven days. Blood and liver tissue samples were collected on postoperative day seven. Liver tissue malondialdehyde, glutathione and Cu-Zn superoxide dismutase activity (SOD) were measured to assess oxidative stress. Binuclear hepato- cyte and Ki-67 antigen levels were measured to evaluate hepatic regeneration. Results: There was no difference between the groups for malondialdehyde, Cu-Zn superoxide dismutase and glutathione levels (p> 0.05). Binuclear nuclei levels were comparable between the H and HT groups (p= 0.06), while taurolidine decreased binuclear hepatocyte levels in the sham operated groups (p= 0.02). Taurolidine application decreased Ki-67 levels after partial hepatectomy (p= 0.001). Conclusion: Taurolidine may cause anti-regenerative effects after partial hepatectomy without causing oxidative damage.

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Section: Discussionmentioning

confidence: 99%

“…Tumor-derived VEGF are blocked by TRD (29). Antiangiogenetic properties of TRD can be considered as a potential drawback for hepatic regeneration.…”

Section: Discussionmentioning

confidence: 99%

Does taurolidine have any effect on liver regeneration and oxidation in the experimental hepatectomy model?

et al. 2021

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“…In fact, some patients have a potentially curative treatment [ 2 ]. However, liver failure is one of the most common complications of liver resection surgery and the main cause of morbidity and mortality [ 3 – 5 ]. Factors predictive of liver failure include patient, surgical, and postoperative factors.…”

Section: Introductionmentioning

confidence: 99%

Effect of the Human Amniotic Membrane on Liver Regeneration in Rats

et al. 2015

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Introduction. Operations are performed for broader liver surgery indications for a better understanding of hepatic anatomy/physiology and developments in operation technology. Surgery can cure some patients with liver metastasis of some tumors. Nevertheless, postoperative liver failure is the most feared complication causing mortality in patients who have undergone excision of a large liver mass. The human amniotic membrane has regenerative effects. Thus, we investigated the effects of the human amniotic membrane on regeneration of the resected liver. Methods. Twenty female Wistar albino rats were divided into control and experimental groups and underwent a 70% hepatectomy. The human amniotic membrane was placed over the residual liver in the experimental group. Relative liver weight, histopathological features, and biochemical parameters were assessed on postoperative day 3. Results. Total protein and albumin levels were significantly lower in the experimental group than in the control group. No difference in relative liver weight was observed between the groups. Hepatocyte mitotic count was significantly higher in the experimental group than in the control group. Hepatic steatosis was detected in the experimental group. Conclusion. Applying the amniotic membrane to residual liver adversely affected liver regeneration. However, mesenchymal stem cell research has the potential to accelerate liver regeneration investigations.

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