Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats

Ateşşahín, Ahmet; Yılmaz, Seval; Karahan, İzzet; Çeribaşı, Ali Osman; Karaoğlu, Aziz

doi:10.1016/j.tox.2005.04.016

Cited by 259 publications

(181 citation statements)

References 24 publications

(46 reference statements)

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“…Lyc treatment, either before or after cisplatin administration, provided a significant protection against cisplatin-induced nephrotoxicity (Atessahin et al, 2005). The histological evaluation of the kidney preparations in pretreatment group also revealed a decrease cisplatin-induced tubular necrosis.…”

Section: Discussionmentioning

confidence: 83%

“…Koul et al (2013) found that Lyc may be beneficial in mitigating doxorubicin induced nephrotoxicity in mice. Protective effects of Lyc have been shown against cisplatin and cyclosporine -induced nephrotoxicity and oxidative stress in rats (Atessahin et al, 2005;Atessahin et al, 2007). These antioxidant and anti-inflammatory effects of Lyc make us think that it may have benefical effects on Mtx-induced nephrotoxicity.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

Oğuz

Koçarslan²,

Tabur³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Methotrexate (Mtx), used for its anticancer and immunsuppresive properties, is known to be a nephrotoxic agent. We aimed to investigate the effects of lycopene (Lyc) alone or combined with melatonin (Mel) on Mtxinduced nephrotoxicity since both of these agents have antioxidant and anti-inflammatory effects. Nephrotoxicity was induced by intraperitoneal administration of methotrexate at a dose of 20 mg/kg. Treatment both with Lyc alone and Lyc combined with Mel provided significant reduction in tumor necrosis factor-alpha, interleukin 1-beta and ceruloplasmin levels in Mtx administered rats. Hovewer, Lyc combined with Mel provided a significant reduction also in NO levels. Hstopathological examination showed that there was an obvious improvement in the degenerative changes compared to Mtx administrated group with the Lyc combined Mel group giving best protection. In conclusion Lyc alone and combined with Mel provided significant improvement against renal damage caused by Mtx, preseumably via antioxidant and anti-inflammatory activities.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

Oğuz

Koçarslan²,

Tabur³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…[1,19] ROS may produce cellular injury and necrosis via several mechanisms, including the peroxidation of membrane lipids, protein denaturation, and DNA damage. [20] Additionally, mitochondria are thought to be a major target of cisplatin, and mitochondrial DNA is heavily damaged by cisplatin, [21] leading to mitochondrial loss of energy production and a release of a mitochondrial serin protease [22] with subsequent cell death. Thus, protective agents have been developed to reduce the damage associated with antitumor drugs by providing site-specific protection for normal tissues without affecting the antitumor efficacy.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Vitamin C on Cisplatin-Induced Renal Damage: A Light and Electron Microscopic Study

2008

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The present study was performed to investigate whether the chronic administration of antioxidant vitamin C provided morphological protection on cisplatin-induced renal damage. Wistar albino male rats were divided into control and two experiment groups, each consisting of six rats. Cisplatin (5 mg/kg/ month) was administered intravenously to the second and third group for three months. After the first application of cisplatin, vitamin C (8 mg/kg/day) to the third group was administered intramuscular for 3 months. At the end of the third month, the kidney specimens of the all groups were obtained. All of these kidney specimens were processed for light and electron microscopical examination. In the second group, most of the renal corpuscle lost their normal appearance and size, especially in the corticomedullary region. The most obvious changes were encountered in the proximal tubules. These changes were tubular dilation, thickening of basement membrane, loss of brush border, vacuolization, and swollenness of mitochondria in the proximal tubule epithelial cells. In addition, infiltration foci were observed mainly in the cortical region. In the third group, which was administered cisplatin plus vitamin C, although the structural damages and morphometric changes were lessened, mononuclear cell infiltration was still observed. This study suggests that the chronic administration of vitamin C may be of therapeutic benefit on cisplatin nephrotoxicity.

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“…It is well-known that cisplatin administration resulted in serious histopathological changes and renal dysfunction that was related to the increase of renal vascular resistance and injury of proximal tubular cells [23,24]. One of the main elimination pathways of toxic metals is excretion by the urine.…”

Section: Discussionmentioning

confidence: 99%

Cisplatin administration influences on toxic and non-essential element metabolism in rats

Szentmihályi

May

Szénási

et al. 2014

Journal of Trace Elements in Medicine and Biology

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Nowadays several papers deal with the effectiveness and side effects of metal complexes, especially cisplatin, in cancer therapy. The excretion of essential metal elements from the body is a serious problem in the treatment, but there are no data concerning the distribution and metabolism of toxic and nonessential elements. Therefore our aim was to study the concentration of some of these elements after treatment with cisplatin. Male Wistar rats (n=20, 175-190 g) were randomly divided into 2 groups (n=10/group). The control group received 1% (w/v) methyl cellulose at 10 mL/kg body weight, p.o. by gastric gavage twice daily for 14 days, while cisplatin was injected i.p. in a single dose of 6.5 mg/kg body weight. Inductively coupled plasma optical emission spectrometry (ICP-OES) was used for measuring Al, B, Ba, Cr, Li, Ni, Pb, Pt, Sb, Si, Sn, Sr and V content in plasma, liver and kidney. Liver total scavenger capacity, diene conjugate content and malondialdehyde concentration were also determined. Cisplatin elevated the free radical reactions in the liver, although redox balance did not change significantly. According to the study it seems that the metabolism of Al, Ba, Cr, Ni, Pb, Sr were changed by the effect of cisplatin, and the most notable alterations were found for Al and Pb. Therefore, besides the toxic effect of and free radical induction by Pt, the side effects of increased levels of other toxic and non-essential elements have to be taken into consideration.

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Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats

Cited by 259 publications

References 24 publications

Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

Protective Effects of Vitamin C on Cisplatin-Induced Renal Damage: A Light and Electron Microscopic Study

Cisplatin administration influences on toxic and non-essential element metabolism in rats

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